Collaborative Research and Action: Empowering an Exposed Community

协作研究和行动：为暴露的社区赋权

• 批准号: 10578519
• 负责人: MICHELE MARCUS
• 金额: $ 30.35万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10578519
• 关键词: Address; Advisory Committees; Affect; Age at Menarche; Agriculture; Animals; Arthralgia; Arthritis; Attention; Autoimmune; Awareness; Body Burden; Breast Feeding; Chemicals; Child; Clinical Trials; Communities; DNA; DNA Methylation; Data; Disasters; Double-Blind Method; Double-blind trial; Educational Materials; Endocrine Disruptors; Environment; Environmental Exposure; Environmental Health; Epigenetic Process; Estrogens; Event; Exposure to; Family; Family Study; Family health status; Fathers; Female; Flame Retardants; Food Chain; Frustration; Funding; Future Generations; Gene Expression; Generations; Genitourinary system; Goals; Growth and Development function; Health; Health Fairs; Health Personnel; Heritability; Human; Human body; Individual; Inherited; Leadership; Liver; Livestock; Malignant Neoplasms; Maternal Exposure; Menarche; Methods; Michigan; Migraine; Mothers; Nerve Degeneration; Neurodegenerative Disorders; Neurologic; Nutritional; Outcome; Pain Disorder; Pancreas; Parents; Participant; Patient Recruitments; Pattern; Persons; Pilot Projects; Poison; Policy Maker; Polybrominated Biphenyls; Public Health; Questionnaires; Randomized; Recording of previous events; Registries; Replacement Arthroplasty; Reproduction; Reproductive system; Research; Research Personnel; Risk; Rivers; Sampling; Scientist; Serum; Ships; Somatic Cell; Spontaneous abortion; Superfund; Time; Universities; Uterus; Woman; Work; adverse outcome; cohort; college; dietary; dietary supplements; empowered; endocrine disruptor exposure; epigenome; experience; immune function; interest; lipophilicity; male; meetings; member; men; methylation pattern; offspring; parent grant; persistent organic pollutants; programs; recruit; reproductive outcome; social media; sperm cell; tool

Project Summary/Abstract: The Michigan PBB Registry was established in order to study the health of thousands of people exposed to brominated flame retardants as a result of the largest agricultural disaster in US history. Previous research by this team has shown significant health effects associated with exposure to polybrominated biphenyls (PBB) including earlier menarche, increased risk of miscarriages and lower estrogen levels among women, and more urogenital problems among men. Over the past few years, Emory researchers have conducted over two dozen community meetings throughout Michigan, collaborated with community partners, shared research findings with the community, responded to community needs, and sought community input for future research plans. This proposed study, collaboratively developed by scientists, community partners, and public health officials, addresses several major concerns expressed by the PBB community. Specifically, affected individuals have expressed interest in a possible treatment to remove PBBs from their bodies, concern about heritable effects from PBB on their children and grandchildren, continuing health concerns beyond those related to reproduction, and frustration that local health-care providers seem unaware of the statewide PBB exposure and/or its possible health effects. To address these concerns, the proposed study has four specific aims. The first is to evaluate the utility of a nutritional aid as a potential means of accelerating the elimination of PBB by conducting a randomized double-blind clinical trial. The second aim will explore the heritability of changes in the epigenome associated with PBB exposure by studying families across three generations. The epigenome of parents, their children, and their grandchildren will be examined to determine if epigenetic patterns associated with direct exposure to PBB of parents are apparent in the children and grandchildren. Aim three will address community concerns regarding additional health effects beyond reproductive outcomes. Participants will complete health questionnaires and provide serum samples for analysis to determine if PBB exposure is associated with neurodegenerative diseases, joint pain/disorder, cancer, immune function and liver/pancreatic problems. If any of the self-identified adverse outcomes are associated with PBB exposure, additional funding will be sought to further explore these associations. Finally, the public health action plan will seek to raise environmental health awareness in Michigan. Educational programs will be developed for healthcare providers, policy-makers, and citizens to increase local capacity to address exposure concerns.

项目摘要/摘要： 密歇根州 PBB 登记处的成立是为了研究数千名接触过 PBB 的人的健康状况 美国历史上最大的农业灾难导致了溴化阻燃剂的使用。之前的研究 该团队已显示出与接触多溴联苯 (PBB) 相关的显着健康影响 包括初潮提前、流产风险增加和女性雌激素水平较低等 男性泌尿生殖系统问题。在过去的几年里，埃默里大学的研究人员进行了两打以上的研究 密歇根州各地的社区会议，与社区合作伙伴合作，分享研究成果 与社区合作，响应社区需求，并寻求社区对未来研究计划的意见。 这项拟议的研究由科学家、社区合作伙伴和公共卫生官员合作开发， 解决了 PBB 社区表达的几个主要问题。具体来说，受影响的个人有 表示对可能的治疗方法有兴趣，以清除体内多溴联苯，担心遗传效应 PBB 对他们的孩子和孙子的影响，除了与 当地医疗保健提供者似乎没有意识到全州范围内的多溴联苯暴露，这让他们感到沮丧 和/或其可能的健康影响。为了解决这些问题，拟议的研究有四个具体目标。这 首先是评估营养辅助剂作为加速消除多溴联苯的潜在手段的效用： 进行随机双盲临床试验。第二个目标将探讨变化的遗传性 通过研究三代家庭，研究与多溴联苯暴露相关的表观基因组。表观基因组 父母、他们的孩子和他们的孙辈将接受检查，以确定表观遗传模式是否 与父母直接接触多溴联苯有关的影响在子孙中很明显。目标三 将解决社区对生殖结果之外的其他健康影响的担忧。 参与者将完成健康调查问卷并提供血清样本进行分析以确定是否患有多溴联苯（PBB） 暴露与神经退行性疾病、关节疼痛/疾病、癌症、免疫功能和 肝脏/胰腺问题。如果任何自我认定的不良后果与多溴联苯暴露有关， 将寻求额外资金来进一步探索这些协会。最后，公共卫生行动计划将 寻求提高密歇根州的环境健康意识。将制定教育计划 医疗保健提供者、政策制定者和公民提高当地解决暴露问题的能力。