Imaging Core

成像核心

• 批准号: 8903709
• 负责人: Craig J Galban
• 金额: $ 36.79万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-05 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8903709
• 关键词: Algorithms; Animals; Archives; Biopsy; Brain Neoplasms; Clinical; Clinical Data; Computer software; Core Facility; Data; Data Analyses; Data Collection; Data Set; Data Storage and Retrieval; Diffusion; Ensure; Equipment; Glioma; Human; Human Resources; Image; Image Analysis; Imaging technology; Institution; Lead; Magnetic Resonance Imaging; Malignant neoplasm of brain; Maps; Modeling; Mus; Operative Surgical Procedures; Outcome; Patient Care; Perfusion; Permeability; Play; Preparation; Procedures; Process; Protocols documentation; Recurrence; Research; Research Personnel; Resources; Retrieval; Role; Scanning; Schedule; Secure; Services; Site; Technical Expertise; Treatment Efficacy; Weight; analytical tool; animal imaging; bioluminescence imaging; computerized data processing; contrast enhanced; data acquisition; design; digital imaging; experience; flexibility; image processing; image reconstruction; imaging biomarker; imaging system; improved; instrumentation; meetings; pre-clinical; programs; research study; success; targeted treatment; treatment response; tumor; water diffusion

The Imaging Core will perform all MR and bioluminescence imaging studies on mouse tumor models for Projects 1 and 2. In addition, the Imaging Core is responsible for all preclinical and clinical data archiving, post-processing and analysis. Core personnel will provide services including: (a) define and implement data acquisition/imaging sequences; (b) assist with animal preparation for imaging; (c) perform all data collection on the 9.4 Tesla MRI, 7 Tesla MRI and Caliper bioluminescence imaging systems; (d) preliminary data processing/image reconstruction and quantitative analysis including PRM analysis for both preclinical (Projects 1 and 2) and clinical imaging data (Project #3) and outcomes data; (e) secure archival of raw data and network transfer of reconstructed data from off-site facilities; (f) scheduling of imaging experiments; and (g) provide support to Program Investigators in technical design and implementation of imaging experiments. These services are designed, in part, after a "clinical MRI service" model since continual, high-volume animal scanning is essential for the success of each project Specific animal MRI protocols will vary with each project, but will primarily include serial studies using: standard T2-weighted; Tl-weighted dynamic contrast enhanced; multislice quantitative water diffusion mapping and dynamic contrast enhancing permeability mapping. The Core will also facilitate the identification of the spatial coordinates needed for biopsy of mouse gliomas using stereotaxic procedures and facilite this activity. The Core will also assist with transfer of MR data to Imbio, LLC for offsite analysis of diffusion and perfusion MRI data sets acquired at multiple sites. Dr. Galban will serve as Core B Director. Dr. Galban has extensive experience in small animal imaging research as well as digital image processing and analysis of clinical MRI data. A Co-investigator and staff will assist Dr. Galban with adapting image processing algorithm's and associated analysis software to ensure the needs of this programmatic research effort are fully met.

成像芯将对小鼠肿瘤模型进行所有MR和生物发光成像研究 项目1和2。此外，成像核心负责所有临床前和临床数据归档， 后处理和分析。核心人员将提供服务，包括：（a）定义和实施数据 采集/成像序列； （b）协助动物制备成像； （c）执行所有数据收集 在9.4 Tesla MRI，7个Tesla MRI和Caliper生物发光成像系统上； （d）初步数据 处理/图像重建和定量分析，包括两个临床前的PRM分析 （项目1和2）以及临床成像数据（项目＃3）和结果数据； （e）安全数据的安全档案 以及来自现场设施的重建数据的网络传输； （f）成像实验的调度；和 （g）在成像实验的技术设计和实施方面为计划调查人员提供支持。 这些服务的设计部分是在“临床MRI服务”模型之后设计的，因为不断，高量的动物 扫描对于每个项目的特定动物MRI协议的成功至关重要 项目，但主要包括串行研究：标准T2加权； TL加权动态对比 增强;多层定量水扩散映射和动态对比度增强了渗透性 映射。核心还将促进识别小鼠活检所需的空间坐标 使用立体定位程序进行神经胶质瘤，并促进此活动。核心还将有助于转移MR 向IMBIO，LLC的数据进行了在多个站点获取的扩散和灌注MRI数据集的异地分析。博士 Galban将担任B核心主管。 Galban博士在小动物成像研究方面拥有丰富的经验 以及临床MRI数据的数字图像处理和分析。共同投资者和工作人员将协助 Galban博士通过适应图像处理算法和相关的分析软件，以确保 这项编程研究工作的需求得到了充分满足。