An Early Imaging Marker of Emphysema
肺气肿的早期影像学标志
基本信息
- 批准号:10412100
- 负责人:
- 金额:$ 47.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-05-28 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAirAirway DiseaseAreaBronchiolitis ObliteransCause of DeathChronic Obstructive Pulmonary DiseaseClassificationClinicalClinical TrialsCollaborationsDataDevelopmentDiagnosisDiseaseDisease ProgressionDoseDyspneaEngineeringEvaluationFoundationsFreezingFundingFutureHealthHumanImageInterdisciplinary StudyLungLung TransplantationMapsMeasuresMethodsMonitorMorbidity - disease rateNoiseOutcomePatient CarePatientsPatternPhysiciansPopulationPublishingPulmonary EmphysemaPulmonary Function Test/Forced Expiratory Volume 1ReportingSamplingScanningSeverity of illnessSignal TransductionSubgroupSurfaceSyndromeSystemTechniquesTestingTissuesTransplant RecipientsUnited States National Institutes of HealthValidationWorkX-Ray Computed Tomographyalveolar destructionbaseclinically relevantcohortdensitydiagnostic valuedisorder subtypeearly onsetend stage diseaseexercise capacityimaging biomarkerimprovedin vivoindexinglung volumemicroCTmortalitynovel strategiespost-transplantprecision medicinepredictive markerpulmonary functionradiologistreconstructionresponsesmall airways disease
项目摘要
PROJECT SUMMARY/ ABSTRACT
Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of death in the US, with nearly 60
million confirmed cases world-wide. Emphysema and small airways disease (SAD) are two main components of
COPD. Emphysema, associated with severe COPD, results in alveolar destruction and is a leading cause of
mortality in this population. Considered at the tissue level an end-stage disease, there are limited treatment
options once diagnosed. As such, there is a clear unmet clinical need to identify markers that predict the early
onset of emphysema. Small airways disease, a treatable component of COPD, has been identified in recent
studies as a potential precursor of emphysema. Although promising, clinical techniques were unable to measure
SAD hindering its use as a marker. This limitation was overcome through our development of a 3D analytical
technique called Parametric Response Mapping (PRM). When applied to computed tomography (CT) scans,
PRM identifies non-emphysematous air trapping, an indirect measure of SAD, even in the presence of
emphysema. In fact, we have demonstrated that the relative lung volume of PRM-derived functional SAD
(%PRMfSAD) predicted spirometric decline in COPD patients, highlighting its potential as an indicator of COPD
progression. Nevertheless, %PRMfSAD provides only a whole-lung assessment, limiting its potential at detecting
the onset and local progression of emphysema. To fully realize PRMfSAD as a predictor of emphysema, we have
advanced our PRM technique by applying topological methods, based on the Minkowski Functionals, to our 3D
PRM classification maps. Referred to as topological PRM (tPRM), this method reported in Scientific Reports
extracts and quantifies features from 3D PRMfSAD resulting in 3D maps of relative density (V; analogous to
%PRMfSAD), surface area (S), mean breadth (B) and Euler-Poincaré statistic (χ). Our preliminary results have
shown that tPRMfSAD correlated better to clinical measures than the %PRMfSAD. Based on these findings, we
hypothesize that our approach will improve PRM sensitivity to disease progression while providing the spatial
information needed to detect the onset of emphysema. We have set out three aims to test our hypothesis. In
Aim 1, we will evaluate the sensitivity of our tPRM method to CT signal variability associated with scanner type,
CT acquisition and reconstruction kernel, as well as corroborate correlations in tPRM to various clinical measures
as previously reported. In Aim 2, we will determine distinctions in tPRM to contributions of emphysema and SAD
as measured from microCT analysis of frozen explanted lung cores obtained from lung transplant recipients with
end-stage COPD. Finally, in Aim 3, we will correlate longitudinal changes over a 5-yr interval in tPRM to clinically-
relevant measures. These aims will be accomplished through support from the NIH-sponsored clinical trial
COPDGene and continued multi-center and multi-disciplinary collaborations. Relevance: We anticipate that the
successful outcome of this effort will improve the diagnostic capability of CT imaging through the realization of
an early marker for the onset of emphysema, leading to improved patient care through precision medicine.
项目概要/摘要
慢性阻塞性肺疾病 (COPD) 是美国第三大死亡原因,有近 60 名患者死于慢性阻塞性肺疾病 (COPD)。
全球有 100 万确诊病例,肺气肿和小气道疾病 (SAD) 是该疾病的两个主要组成部分。
慢性阻塞性肺病(COPD)与严重慢性阻塞性肺病(COPD)相关,会导致肺泡破坏,是慢性阻塞性肺病(COPD)的主要原因。
该人群的死亡率在组织水平上被视为终末期疾病,治疗方法有限。
因此,确定预测早期症状的标记物显然是未得到满足的临床需求。
最近发现小气道疾病是慢性阻塞性肺病(COPD)的一个可治疗的组成部分。
作为肺气肿潜在前兆的研究虽然很有希望,但临床技术无法测量。
SAD 阻碍了其作为标记的使用,我们通过开发 3D 分析技术克服了这一限制。
称为参数响应映射 (PRM) 的技术应用于计算机断层扫描 (CT) 时,
PRM 可识别非肺气肿性空气滞留,这是 SAD 的间接测量方法,即使存在
事实上,我们已经证明 PRM 衍生的功能性 SAD 的相对肺体积。
(%PRMfSAD) 预测 COPD 患者的肺活量下降,凸显其作为 COPD 指标的潜力
然而,%PRMfSAD 仅提供全肺评估,限制了其检测的潜力。
为了充分认识 PRMfSAD 作为肺气肿的预测因子,我们有
通过将基于 Minkowski 泛函的拓扑方法应用到我们的 3D 模型中,改进了我们的 PRM 技术
PRM 分类图称为拓扑 PRM (tPRM),该方法在 Scientific Reports 中报道。
从 3D PRMfSAD 中提取并量化特征,从而生成相对密度的 3D 地图(V;类似于
%PRMfSAD)、表面积(S)、平均宽度(B)和欧拉-庞加莱统计量(χ)。
显示 tPRMfSAD 与临床测量的相关性比 %PRMfSAD 更好。根据这些发现,我们。
推进我们的方法将提高 PRM 对疾病进展的敏感性,同时提供空间
检测肺气肿发作所需的信息 我们制定了三个目标来检验我们的假设。
目标 1,我们将评估 tPRM 方法对与扫描仪类型相关的 CT 信号变异性的敏感性,
CT 采集和重建内核,以及证实 tPRM 与各种临床测量的相关性
如之前报道的,在目标 2 中,我们将确定 tPRM 对肺气肿和 SAD 的影响的区别。
通过对从肺移植受者获得的冷冻移植肺芯进行 microCT 分析来测量
最后,在目标 3 中,我们将 tPRM 的纵向变化与临床相关。
这些目标将通过 NIH 资助的临床试验的支持来实现。
COPDGene 和持续的多中心和多学科合作 相关性:我们预计
这项工作的成功成果将通过实现以下目标来提高 CT 成像的诊断能力:
肺气肿发作的早期标志,通过精准医疗改善患者护理。
项目成果
期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Implementation and evaluation of ultra-low dose CT in early cystic fibrosis lung disease.
- DOI:10.1183/13993003.00286-2023
- 发表时间:2023-07
- 期刊:
- 影响因子:24.3
- 作者:Bayfield, Katie J.;Weinheimer, Oliver;Boyton, Christie;Fitzpatrick, Rachel;Middleton, Anna;Kennedy, Brendan;Blaxland, Anneliese;Jayasuriya, Geshani;Caplain, Neil;Issa, Hana;Goetti, Robert;Wielpuetz, Mark O.;Yu, Lifeng;Galban, Craig J.;Robinson, Terry E.;Bartholmai, Brian;Fitzgerald, Dominic;Selvadurai, Hiran;Robinson, Paul D.
- 通讯作者:Robinson, Paul D.
Assessing small airways dysfunction in asthma, asthma remission and healthy controls using particles in exhaled air.
使用呼出空气中的颗粒评估哮喘中的小气道功能障碍、哮喘缓解和健康控制。
- DOI:10.1183/23120541.00202-2019
- 发表时间:2019
- 期刊:
- 影响因子:4.6
- 作者:Carpaij,OrestesA;Muiser,Susan;Bell,AlexJ;Kerstjens,HuibAM;Galban,CraigJ;Fortuna,AleksaB;Siddiqui,Salman;Olin,Anna-Carin;Nawijn,MartijnC;vandenBerge,Maarten
- 通讯作者:vandenBerge,Maarten
Investigating the Incidence of Pulmonary Abnormalities as Identified by Parametric Response Mapping in Patients With Lung Cancer Before Radiation Treatment.
- DOI:10.1016/j.adro.2022.100980
- 发表时间:2022-07
- 期刊:
- 影响因子:2.3
- 作者:Owen, Daniel R;Sun, Yilun;Irrer, Jim C;Schipper, Matthew J;Schonewolf, Caitlin A;Galban, Stefanie;Jolly, Shruti;Haken, Randall K Ten;Galban, C J;Matuszak, M M
- 通讯作者:Matuszak, M M
An assessment of the correlation between robust CT-derived ventilation and pulmonary function test in a cohort with no respiratory symptoms.
在无呼吸道症状的队列中评估稳健 CT 衍生通气与肺功能测试之间的相关性。
- DOI:10.1259/bjr.20201218
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Nair,GirishB;Galban,CraigJ;Al-Katib,Sayf;Podolsky,Robert;vandenBerge,Maarten;Stevens,Craig;Castillo,Edward
- 通讯作者:Castillo,Edward
MDCT-based longitudinal automated airway and air trapping analysis in school-age children with mild cystic fibrosis lung disease.
- DOI:10.3389/fped.2023.1068103
- 发表时间:2023
- 期刊:
- 影响因子:2.6
- 作者:Weinheimer O;Konietzke P;Wagner WL;Weber D;Newman B;Galbán CJ;Kauczor HU;Mall MA;Robinson TE;Wielpütz MO
- 通讯作者:Wielpütz MO
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Craig J Galban其他文献
Craig J Galban的其他文献
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{{ truncateString('Craig J Galban', 18)}}的其他基金
Parametric Response Mapping (PRM) for the detection of chronic lung injury in hematopoietic cell transplant recipients
用于检测造血细胞移植受者慢性肺损伤的参数响应图 (PRM)
- 批准号:
10683080 - 财政年份:2022
- 资助金额:
$ 47.45万 - 项目类别:
Parametric Response Mapping (PRM) for the detection of chronic lung injury in hematopoietic cell transplant recipients
用于检测造血细胞移植受者慢性肺损伤的参数响应图 (PRM)
- 批准号:
10414583 - 财政年份:2022
- 资助金额:
$ 47.45万 - 项目类别:
Commercialization of a CT-based Technique for BOS Assessment
基于 CT 的 BOS 评估技术的商业化
- 批准号:
10165795 - 财政年份:2018
- 资助金额:
$ 47.45万 - 项目类别:
Commercialization of a CT-based Technique for BOS Assessment
基于 CT 的 BOS 评估技术的商业化
- 批准号:
9763983 - 财政年份:2018
- 资助金额:
$ 47.45万 - 项目类别:
Development of Parametric Response Mapping Software for Clinical Cancer Response Assessment
开发用于临床癌症反应评估的参数反应图软件
- 批准号:
9767576 - 财政年份:2016
- 资助金额:
$ 47.45万 - 项目类别:
CT-based Biomarker for Diagnosis of COPD Phenotypes and Disease Progression
基于 CT 的生物标志物用于诊断 COPD 表型和疾病进展
- 批准号:
8815199 - 财政年份:2013
- 资助金额:
$ 47.45万 - 项目类别:
CT-based Biomarker for Diagnosis of COPD Phenotypes and Disease Progression
基于 CT 的生物标志物用于诊断 COPD 表型和疾病进展
- 批准号:
9010975 - 财政年份:2013
- 资助金额:
$ 47.45万 - 项目类别:
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