A new paradigm of cardiovascular MRI for pediatric congenital heart disease

小儿先天性心脏病心血管 MRI 的新范例

• 批准号: 8985563
• 负责人: Peng Hu
• 金额: $ 67.21万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8985563
• 关键词: Acceleration; Address; Adult; Affect; Anatomy; Angiography; Apnea; Birth; Blood Vessels; Blood flow; Bolus Infusion; Breathing; Cardiac; Cardiac Catheterization Procedures; Cardiovascular system; Catheterization; Child; Childhood; Cine Magnetic Resonance Imaging; Clinical; Communities; Complement; Complex; Congenital Abnormality; Contrast Media; Coronary artery; Data; Development; Diagnosis; Diagnostic; Dose; Echocardiography; Environmental air flow; Evaluable Disease; Evaluation; Exposure to; Financial compensation; Gadolinium; General Anesthesia; Geometry; Goals; Heart; Hybrids; Image; Institution; Intubation; Ionizing radiation; Knowledge; Label; Live Birth; Magnetic Resonance Imaging; Methods; Motion; Patients; Phase; Physicians; Physiologic pulse; Play; Protocols documentation; Radial; Reference Standards; Resolution; Role; Sampling; Scanning; Scheme; Signal Transduction; Slice; Structure; Techniques; Testing; Thick; Time; To specify; Validation; Ventilator; base; cohort; congenital heart disorder; contrast enhanced; experience; falls; ferumoxytol; follow-up; gadolinium oxide; heart imaging; imaging modality; iron deficiency; iron oxide; nanoparticle; neonate; nephrotoxicity; patient safety; pressure; prevent; public health relevance; radiologist; reconstruction; respiratory; treatment planning

 DESCRIPTION (provided by applicant): Congenital heart disease (CHD) is the most common congenital defect affecting approximately 1% of live births. Initially developed and optimized for adults, cardiovascular MRI (CMR) is increasingly used in pediatric CHD patients to complement echocardiography and invasive angiography for anatomical and functional evaluation of the heart and blood vessels. For children, the non-invasiveness, unrestricted field of view, lack of contrast nephrotoxicity and absence of ionizing radiation make MRI an attractive imaging modality, as many of the patients will likely need sequential imaging and follow-up in the long term. However, current CMR is limited by the breath-holding period, the need to capture the first-pass of a gadolinium (Gd) bolus and relatively thick 2D slices in cardiac cine MRI. Consequently, despite yielding exquisitely detailed information on extra-cardiac vascular anatomy, current CMR methods fall short of providing comparable definition of dynamic intra-cardiac anatomy, such as the cardiac chambers, valves, coronary arteries, and other pulsatile blood vessels, despite the fact that the status of these structures often determines the basis for treatment planning. We propose a new paradigm of CMR in pediatric CHD to address these issues. Completion of the project will result in the clinical deployment of a set of MRI pulse sequences, image acquisition and reconstruction strategies CMR in pediatric CHD patients, and successful validation in a cohort of patients of its diagnostic value.

 描述（由适用提供）：先天性心脏病（CHD）是最常见的先天性缺陷，影响了大约1％的活产。心血管MRI（CMR）最初针对成年人开发和优化，越来越多地用于儿科冠心病患者中，以补充超声心动图和侵入性血管造影，以对心脏和血管进行解剖和功能评估。对于儿童来说，非侵入性，不受限制的视野，缺乏对比肾毒性和缺乏电离辐射的缺乏使MRI成为有吸引力的成像方式，因为许多患者可能需要长期进行顺序成像和随访。然而，当前的CMR受呼吸持续期限的限制，需要在心脏Cine MRI中捕获Gadolinium（GD）推注的第一次通用和相对较厚的2D切片。因此，dospite产生了有关心脏外血管解剖结构的精确详细信息，当前的CMR方法无法提供动态内部解剖结构的可比定义，例如心脏室，瓣膜，瓣膜，冠状动脉，冠状动脉和其他pul骨血管，这些事实通常确定这些结构的状态来确定基础的基础。我们提出了一个新的CMR在儿科冠心病中的范式来解决这些问题。该项目的完成将导致一组MRI脉冲序列，图像采集和重建策略CMR CMR在儿科冠心病患者中的临床部署，并在一系列具有其诊断价值的患者中成功验证。