Robust Cardiac Self-Gating For Fetal Cardiac MRI

适用于胎儿心脏 MRI 的强大心脏自门控

• 批准号: 8469905
• 负责人: Peng Hu
• 金额: $ 21.99万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-15 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8469905
• 关键词: Address; Adult; Affect; Amniotic Fluid; Anatomy; Aortic coarctation; Birth; Blood flow; Cardiac; Clinical; Congenital Abnormality; Data; Diagnosis; Diagnostic; Disease; Echocardiography; Electrocardiogram; Fetus; Financial compensation; Goals; Gold; Image; Ionizing radiation; Live Birth; Magnetic Resonance Imaging; Methodology; Methods; Modality; Morphologic artifacts; Motion; North America; Obesity; Oligohydramnios; Patients; Peripheral; Phase; Physiologic pulse; Positioning Attribute; Pregnant Women; Prenatal Diagnosis; Preparation; Radiation; Resolution; Second Pregnancy Trimester; Signal Transduction; Techniques; Technology; Third Pregnancy Trimester; Ultrasonography; Validation; base; bone; clinical practice; cohort; congenital heart disorder; data acquisition; design; fetal; heart function; heart motion; imaging modality; improved; infancy; innovation; novel; phase change; pregnant; prospective; respiratory; sensor; soft tissue

DESCRIPTION (provided by applicant): Congenital heart disease (CHD) is the most common congenital defect affecting eight per thousand live births in North America. Prenatal diagnosis of CHD allows for improved and better informed decisions on patient management before and after birth. In current clinical practices, an ultrasound examination of the anatomy and function of the heart as well as the blood flow through the valves and great vessels is usually used for diagnosis of CHD. However, the use of ultrasound is limited in certain patients due to various reasons. In these cases, fetal cardiac MRI is a promising alternative imaging modality due to its excellent soft tissue contrast and lack of radiation exposure. Advances in cardiac MRI technology in the last two decades have enabled more widespread use of cardiac MRI in the clinical setting. However, the use of MRI for fetal cardiac imaging remains in its infancy due to various reasons. Aside from the more stringent requirement on spatial resolution for fetal imaging, a major impediment is lack of a robust cardiac motion gating technology. In cardiac MRI, the image acquisition is typically synchronized to the cardiac cycle using either an electrocardiogram (ECG) or peripheral pulse signal to minimize the artifacts and image blurring resulting from cardiac motion or to obtain a cardiac phase resolved image. However, these signals are simply not available for fetal MRI. Therefore, a robust cardiac gating strategy is needed for fetal cardiac MRI to be used clinically. The overall goal of this project is to develop techniques that can reliably provide a cardiac motion self- gating signal for use in fetal cardiac MRI. In this project, we propose several technical innovations that can be used routinely to obtain reliable fetal cardiac self-gating signal. The developed strategies will then be evaluated on a cohort of pregnant women who are referred to fetal ultrasound for suspected congenital heart disease.

描述（由申请人提供）：先天性心脏病（CHD）是最常见的先天性缺陷，影响北美的每千只活出生。冠心病的产前诊断允许在出生前后对患者管理做出改进，明智的决定。在当前的临床实践中，通常使用对心脏的解剖结构和功能以及通过瓣膜和巨大血管的血流进行超声检查。但是，由于各种原因，某些患者的超声使用受到限制。在这些情况下，由于其出色的软组织对比和缺乏辐射暴露，胎儿心脏MRI是一种有希望的替代成像方式。在过去的二十年中，心脏MRI技术的进步使在临床环境中更广泛地使用心脏MRI。但是，由于各种原因，将MRI用于胎儿心脏成像仍处于起步阶段。除了对胎儿成像的空间分辨率更严格的要求外，主要障碍是缺乏强大的心运动门控技术。在心脏MRI中，通常使用心电图（ECG）或外围脉冲信号将图像采集与心脏循环同步，以最大程度地减少伪像，并因心脏运动而导致的图像模糊或获得心脏相位验证的图像。但是，这些信号根本无法用于胎儿MRI。因此，胎儿心脏MRI临床使用需要强大的心脏门控策略。该项目的总体目标是开发可以可靠地提供心脏运动自我门控信号的技术，以用于胎儿心脏MRI。在这个项目中，我们提出了几项技术创新，这些创新可通常用于获得可靠的胎儿心脏自我门控信号。然后，将对已发达的策略进行评估，这些策略被称为胎儿超声，以备胎胎心脏病。