Miami Womens Interagency HIV Study WIHS

迈阿密妇女机构间艾滋病毒研究 WIHS

• 批准号: 8787709
• 负责人: Margaret A Fischl
• 金额: $ 150.21万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8787709
• 关键词: AIDS/HIV problem; Address; Adherence; Adoption; Adult; Age; Aging; Aging-Related Process; Alcohol or Other Drugs use; Anti-Retroviral Agents; Area; Behavioral; Biological; Cardiac; Caribbean region; Caring; Central America; Child; Cities; Clinical; Clinical Data; Cohort Studies; Collaborations; Collection; Communities; County; Coupled; Coupling; Crack Cocaine; Data; Decision Making; Development; Diagnosis; Disease; Disease Outcome; Disease Progression; Distress; Economics; Elderly; Enrollment; Ensure; Epidemic; Epidemiology; Ethnic group; Florida; Future; Genetic Variation; Goals; Grant; Growth; HIV; HIV Infections; HIV-1; Health; Health Services Accessibility; Healthcare; Heterosexuals; High Prevalence; Homelessness; Human Resources; Immigrant; Immigration; Immune; Immunosuppression; Incidence; Individual; Infection; Infection prevention; Inflammation; Institutional Review Boards; Interpersonal Violence; Investigation; Leadership; Life; Longevity; Measures; Mental Health; Mental disorders; Methods; Minority; Monitor; Outcome; Participant; Pathogenesis; Pediatrics; Play; Population; Population Heterogeneity; Populations at Risk; Positioning Attribute; Poverty; Prevalence; Primary Health Care; Public Health Schools; Quality Control; Race; Recovery; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Risk; Risk Factors; Role; Sample Size; Scientist; Services; Site; South America; Southeastern United States; Specimen; Treatment outcome; Unemployment; United States; Universities; Viral; Vulnerable Populations; Woman; Youth; antiretroviral therapy; base; behavioral study; behavioral/social science; clinical epidemiology; cocaine use; cohort; demographics; design; experience; flexibility; immune activation; immune function; improved; influenza virus vaccine; innovation; insight; interest; intravenous drug use; medical schools; meetings; metropolitan; middle age; multidisciplinary; novel; population based; programs; reproductive; research study; response; social; social science research; success; transmission process; uptake; young adult

DESCRIPTION (provided by applicant): A growing proportion of U.S. women with HIV infection are from the Southeastern United States. Compared to all other states in the Southern region of the U.S., Florida has the highest number of HIV-infected individuals and the highest rates of HIV transmission. Miami-Dade County has one of the highest rates of new infections among women and the prevalence of HIV among women was among the highest in a national study of 21 epicenter cities in the U.S. Heterosexual transmission and intravenous drug use were the major risk factors for infection. Compounding these issues, Miami-Dade County ranks high among U.S. areas in measures of social and economic distress. The Women's Interagency HIV Study (WIHS) seeks to expand its efforts to better understand the current epidemiology of HIV infection in women with the identification of new sites from the Southern region of the U.S. The Miami WIHS is well positioned to engage women with HIV infection and at risk for HIV infection that are representative of this region and the changing demographics of the HIV epidemic, as well as addressing important current treatment outcomes and the impact of disassociation from care among hard-to-reach populations (e.g. substance abusing individuals). Miami sits at the portal to the Caribbean and Central and South America and, as a result of the high rates of immigration from these regions; the women infected with HIV belong to a wide, diverse population. In addition, the HIV-infected population of women in Miami spans generational boundaries from pediatrics through to the elder. This project is a multiple PI project between the University of Miami Miller School of Medicine and the Columbia University Mailman School of Public Health with collaboration from the University of Florida. We will seek to enroll a diverse cohort of 300 youth, young adult and adult women, including women who are at-risk for HIV, those with limited disease progression, those with newly recognized infection, who are antiretroviral treatment na¿ve and antiretroviral treatment experienced participants, and who are in care, intermittently in care and not in care. A highly experienced and diverse team of researchers has been assembled to ensure the success of this program, including clinical, basic and behavioral/social scientists, with strong ties to th community. The specific aims outlined respond directly to the overall WIHS scientific goals and advance and expand the WIHS basic, clinical and epidemiologic/behavioral/social science research agenda. The proposed scientific agenda taps into the experience and expertise of the Miami WIHS researchers to examine critically important and scientifically rigorous research questions. The proposed research projects will examine the impact of aging on immune functionality; reproductive decision making among young adult and adult women living with HIV/AIDS; increasing viral diversity and the impact of HIV-1 non-B subtype infections on the clinical course of HIV and response to therapy; and the interplay of crack cocaine use and associated co-occurring epidemics (mental health, poverty, unemployment and interpersonal violence with uptake of optimal antiretroviral therapy and engagement and retention in care. By coupling the diverse population base of HIV-infected and at risk women with the recognized strengths in HIV/AIDS research, the Miami WIHS is perfectly situated to advance the overall WIHS scientific agenda of defining clinical outcomes among women across their lifespan, including the uptake of antiretroviral therapy; use and retention of HIV primary care and other ancillary services; treatment outcomes on viral suppression, immune recovery and normalization of the effects of HIV, and disease pathogenesis, as well as, promoting and advancing local scientific research goals.

描述（由适用提供）：越来越多的美国艾滋病毒感染妇女来自美国东南部。与美国南部地区的所有其他州相比，佛罗里达州的艾滋病毒感染者人数最多，艾滋病毒传播率最高。迈阿密戴德县是妇女新感染率最高的之一，在全国对21个震中城市的研究中，妇女的艾滋病毒流行是美国异性恋传播和静脉毒品使用的最高研究，是感染的主要风险因素。在这些问题上，迈阿密戴德县在社会和经济困扰的测量中排名很高。 妇女的妇女间艾滋病毒艾滋病毒研究（WIHS）试图扩大其努力，以更好地了解妇女当前的艾滋病毒感染流行病学，并确定来自美国南部地区的新地点，迈阿密WIHS在艾滋病毒感染和艾滋病毒感染风险中的疾病和当前的造成的造成的造成的人群的影响很大，并影响了人们对HIV的影响，以及对HIV的影响，以及对HIV的影响，以及对HIV的影响不佳，以及对人的影响不佳，以及对人的影响不佳的影响。与难以触及的人群之间的护理（例如滥用滥用的人）之间的关注。由于这些地区的移民率很高，迈阿密坐在加勒比海，中部和南美的门户网站。感染了艾滋病毒的妇女属于广泛的潜水人群。此外，迈阿密妇女的艾滋病毒感染人群跨越了从儿科到年龄较大的世代界限。 该项目是迈阿密米勒大学医学院与佛罗里达大学合作的哥伦比亚大学邮政公共卫生学院之间的多个PI项目。我们将寻求招募300名青年，年轻成年和成年妇女组成的多样性队列，其中包括患有疾病有限的妇女，患有有限的疾病进展的妇女，那些具有新认可的感染的妇女，他们正在接受抗逆转录病毒治疗的NAâVE和抗逆转录病毒治疗经验的抗逆转录病毒治疗，并且在护理和没有护理方面正在护理和没有护理。一支经验丰富且多样化的研究人员团队已经组装，以确保该计划的成功，包括临床，基本和行为/社会科学家，与TH社区有着密切的联系。具体的目的概述了直接对WIHS科学目标的反应，并促进并扩大WIHS基本，临床和流行病学/行为/社会科学研究议程。拟议的科学议程介绍了迈阿密WIHS研究人员的经验和专家，以研究至关重要的，科学严格的研究问题。拟议的研究项目将研究衰老对免疫功能的影响；患有艾滋病毒/艾滋病的年轻成年和成年妇女的生殖决策；病毒多样性的增加以及HIV-1非亚型亚型感染对艾滋病毒临床过程和对治疗的反应的影响；以及裂纹可卡因使用以及相关的同时发生发作的相互作用（心理健康，贫困，失业和人际关系暴力，并吸收了最佳的抗逆转录病毒疗法，以及保留护理中的互动和保留。 通过将感染艾滋病毒感染的艾滋病毒和妇女的多样性人口基础结合到具有公认的艾滋病毒/艾滋病研究中的优势的妇女，迈阿密世界自由贸易协会非常适合促进整个妇女的临床成果，以促进整个妇女的临床成果，包括对抗逆转录病毒治疗的摄入；使用和保留HIV初级保健和其他辅助服务；艾滋病毒作用以及疾病发病机理的影响以及促进和促进当地科学研究目标的治疗结果。