Women, Intersectionality, Substance Use and HIV ( WISH)

妇女、交叉性、药物滥用和艾滋病毒 (WISH)

• 批准号: 10484071
• 负责人: Jennifer Payaal Jain
• 金额: $ 18.64万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10484071
• 关键词: AIDS/HIV problem; Address; Adherence; Amines; Anti-Retroviral Agents; Award; Black race; Caring; Cohort Studies; Data; Development Plans; Discrimination; Drug usage; Epidemic; Epidemiologic Methods; Evidence based intervention; Failure; Feedback; Focus Groups; Goals; HIV; Health; Health Personnel; High Prevalence; Inequality; Intervention; Interview; Lead; Learning; Link; Manuscripts; Mediator of activation protein; Mentored Research Scientist Development Award; Mentors; Methodology; Methods; Modeling; Monitor; Outcome; Persons; Pilot Projects; Population; Process; Protocols documentation; Race; Reporting; Research; Research Support; Resources; San Francisco; Science; Stigmatization; Structure; Surveys; System; Techniques; Testing; Time; Training; Training Activity; Treatment outcome; United States; United States National Institutes of Health; Viral; Woman; Work; Writing; acceptability and feasibility; antiretroviral therapy; arm; career; career development; experience; improved; intersectionality; knowledge base; mortality; post intervention; prospective; racial and ethnic; racial diversity; recruit; resilience; response; satisfaction; skills; social stigma; substance use; success; theories; therapy adherence; therapy design; treatment as prevention; treatment optimization

PROJECT SUMMARY/ABSTRACT The purpose of this Mentored Research Scientist Development Award (K01) is to provide the candidate with the training and expertise needed to transition into an independent research career focused on intersectional approaches to optimize HIV treatment and intervention. This K01 features a robust career development plan and carefully linked research strategy. The overall objective of the research component of this K01 is to examine how intersectional stigma and discrimination lead to inequalities in HIV treatment outcomes and explore how resilience promotes engagement in HIV care among racially diverse women living with HIV who use drugs (WLHIV-WUD) in the United States (US). This information will inform the selection and systematic adaptation of an HIV-related evidence-based intervention (EBI) to facilitate engagement in care among WLHIV-WUD. This will be achieved through the following three specific aims: 1) to assess the impact of stigma and discrimination on inequalities in HIV treatment outcomes across intersections of drug use and race among racially diverse WLHIV in the US; 2) to systematically adapt an HIV-related EBI to mitigate the impact of intersectional stigma and discrimination and cultivate resilience to facilitate HIV care engagement among racially diverse WLHIV-WUD in San Francisco, CA; and 3) to evaluate the acceptability and feasibility of the adapted intersectionality-informed HIV care engagement intervention among racially diverse WLHIV-WUD in San Francisco, CA. Dr. Jennifer Jain is the perfect candidate to conduct this research because of her strong knowledge base in epidemiological methods and HIV and substance use research. During the 5-year award period, Dr. Jain will achieve the following career development objectives: 1) gain content expertise in intersectionality theory and research with an emphasis on HIV care engagement among WLHIV-WUD in the US; 2) develop methodological expertise in advanced statistical techniques for quantitative intersectionality and mixed methods; 3) acquire training in intervention science, including the adaptation and testing of evidence- based interventions focused on HIV care engagement among WLHIV-WUD in the US; 4) build skills for a successful independent research career, including grantsmanship, scientific manuscript writing and collaborative cross-disciplinary research. This will be attained through the completion of a diverse set of training activities including mentor-directed learning, formal course work, seminars, and real-world research experience. The proposed research is highly consistent with current NIH priorities to: 1) conduct HIV-related intersectional stigma research; 2) improve health outcomes among people living with HIV who use drugs; and 3) accelerate scientific discoveries in HIV/AIDS and substance use research. Moreover, this research supports Dr. Jain’s pursuit of an independent career in research focused on intersectional approaches to enhance HIV treatment and intervention among racially diverse WLHIV-WUD in the US.

项目摘要/摘要 这个指导的研究科学家发展奖（K01）的目的是为候选人提供 过渡到关注交叉路口的独立研究职业所需的培训和专业知识 优化艾滋病毒治疗和干预的方法。这个K01具有强大的职业发展计划 并经过精心联系的研究策略。该K01的研究部分的总体目标是 检查交叉污名和歧视如何导致HIV治疗结果的不平等和 探索弹性如何促进与艾滋病毒的多元化妇女中的艾滋病毒关怀的参与 在美国使用药物（WLHIV-WUD）（美国）。此信息将为选择和系统性提供信息 适应与HIV相关的循证干预（EBI），以促进参与护理 wlhiv-wud。这将通过以下三个特定目的来实现：1）评估污名的影响 以及跨药物使用和种族跨越艾滋病毒治疗结果的不平等现象的歧视 在美国种族潜水员； 2）系统地调整与HIV相关的EBI以减轻 交叉的污名和歧视和培养弹性，以促进艾滋病毒的护理参与 在加利福尼亚州旧金山的种族多样化的WLHIV-WUD； 3）评估可接受性和可行性 适应性的交叉性信息在大概潜水者中 加利福尼亚州旧金山詹妮弗·贾恩（Jennifer Jain）博士是进行这项研究的理想候选人，因为她的坚强 流行病学方法以及艾滋病毒和药物使用研究的知识基础。在5年奖励期间 时期，Jain博士将实现以下职业发展目标：1）获得内容专业知识 交叉性理论和研究重点是WLHIV-WUD之间的艾滋病毒护理参与 我们; 2）在高级统计技术中开发方法学专业知识，用于定量交叉和 混合方法； 3）获得干预科学的培训，包括对证据的适应和测试 - 基于干预措施的重点是美国WLHIV-WUD之间的艾滋病毒护理参与； 4）建立技能 成功的独立研究职业，包括授予技巧，科学手稿写作和 协作跨学科研究。这将通过一组潜水 培训活动，包括精神上的学习，正式课程工作，半学院和现实世界研究 经验。拟议的研究与当前的NIH优先级高度一致：1）与HIV有关 交叉污名研究； 2）改善使用毒品的艾滋病毒患者的健康状况；和 3）加速艾滋病毒/艾滋病和物质使用研究中的科学发现。而且，这项研究支持 Jain博士追求独立的研究职业，重点是增强艾滋病毒的交叉方法 在美国，大概潜水者的治疗和干预。