Translational Hearing Center

转化听力中心

基本信息

批准号：
10090986
负责人：
Peter Stephen Steyger
金额：
$ 226.33万
依托单位：
CREIGHTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-03-05 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10090986
关键词：
Academic Medical Centers Academic achievement Achievement Address Advisory Committees Affect Aging Attenuated Auditory Auditory Perception Award Basic Science Biological Assay Biomedical Research Biometry Center for Translational Science Activities Centers of Research Excellence Child Cities Clinical Clinical Investigator Clinical Research Clinical Trials Complement Development Drug Delivery Systems Drug Prescriptions Drug Screening Ensure Environment Etiology Evaluation Research Exposure to Fetal Alcohol Spectrum Disorder Fostering Foundations Functional disorder Funding Funding Mechanisms Future Genetic Polymorphism Genomics Goals Grant Great Plains Health Health system Hearing Hearing problem Hospitals Human Impaired cognition Income Individual Infant Inflammation Infrastructure Institution International Intervention Investigation Investigational Drugs Investigational New Drug Application Labyrinth Language Lead Life Longevity Malignant Neoplasms Medical Medical center Mental Depression Mentors Mentorship Military Personnel Mitochondria Multicenter Studies Nebraska Neonatal Intensive Care Units Neural Pathways Noise Noise-Induced Hearing Loss Occupational Peripheral Pharmacologic Substance Pharmacology Phase Pilot Projects Population Production Quality of life Rehabilitation therapy Research Research Activity Research Personnel Research Project Grants Risk Savings Secure Sensory Services Social Interaction Study Section System Technology Therapeutic Therapeutic Intervention Translating Translational Research Translations Universities Withdrawal aging population base boys career cisplatin induced hearing loss clinical center drug discovery efficacy study efficacy validation fall risk hearing impairment hearing loss phenotype hearing loss risk hearing preservation hearing restoration high risk lead candidate multidisciplinary neonate ototoxicity patient population preclinical study preservation programs psychosocial recruit safety study skills social socioeconomics success therapeutic candidate translational scientist voucher working group

项目摘要

PROJECT SUMMARY/ABSTRACT Overall Plan for the Translational Hearing Center This Center of Biomedical Research Excellence (COBRE) application is to establish the Translational Hearing Center, administered by centrally-located Creighton University, with Boys Town National Research Hospital (BTNRH) and the University of Nebraska Medical Center (UNMC), as institutional partners. Our overall goal is to build a critical mass of academic translational researchers developing therapeutic interventions to preserve or restore hearing and vestibular function from a wide range of etiologies that cause hearing loss and vestibular deficits. Hearing loss in infants and children results in delayed acquisition of listening and spoken language skills critical for academic achievement and maximal career trajectories of affected individuals. In the aging population, hearing loss and vestibular deficits without appropriate rehabilitation accelerates aging and cognitive decline. Aim 1: Develop the infrastructure and expertise base for translational auditory and vestibular research. COBRE funding will enable an Administrative Core within the Center to provide a unique, transformational research environment for junior investigators to translate their basic science discoveries into therapeutic strategies that preserve or restore hearing and vestibular function. This will establish a broader nonclinical research program. The Administrative Core will coordinate interactions between project leaders with their Mentors, and an External Advisory Committee. The Administrative Core will develop a Drug Discovery and Delivery Core that will coordinate necessary drug screen assays and production of derivatives of lead compounds and their delivery to the inner ear and associated central neural pathways, as well as an Auditory Vestibular Technology Core to validate the efficacy of lead candidate ototherapeutics hits. Aim 2: Build a critical mass of funded investigators leading translational auditory and vestibular research. We will examine both peripheral and central mechanisms of hearing loss and vestibular dysfunction, and identify pharmacotherapeutic strategies preserve or restore hearing and vestibular function, with multiple levels of research funding for investigators. We also have an outstanding Mentoring Plan for project leaders, complementing their expertise with senior investigations as Internal Mentors and biostatistical support, as well as outside investigators with translational and clinical expertise as External Mentors. Additional mentoring is provided by Research Core staff, grantsmanship classes and Mock Study Sections of proposals prior to review. Evaluations of research progress, and all other Center activities, are also key to optimize Center success. The Center will also benefit from the burgeoning translational research environment in Omaha, Nebraska. Future plans call for continued expansion of the Center to include submission of Investigational New Drug applications, safety and efficacy studies and clinical trials in partnership with patient populations served by Creighton University’s academic medical center, Catholic Health Initiatives (CHI) Health system, BTNRH and UNMC.

项目概要/摘要转化听力中心总体规划该生物医学研究卓越中心 (COBRE) 的申请旨在建立转化听证会该中心由位于市中心的克赖顿大学和男孩镇国家研究医院管理 (BTNRH) 和内布拉斯加大学医学中心 (UNMC) 作为机构合作伙伴，我们的总体目标是。建立足够数量的学术转化研究人员，开发治疗干预措施以保存或从导致听力损失和前庭功能障碍的多种病因中恢复听力和前庭功能婴儿和儿童的听力损失会导致听力和口语技能的延迟获得。对于受影响个体的学业成就和最大职业轨迹至关重要。如果没有适当的康复，听力损失和前庭缺陷会加速衰老和认知能力下降。目标 1：开发转化听觉和前庭研究的基础设施和专业知识基础。 COBRE 资金将使中心内的行政核心能够提供独特的、变革性的为初级研究人员提供将基础科学发现转化为治疗药物的研究环境保留或恢复听力和前庭功能的策略这将建立更广泛的非临床功能。研究计划的行政核心将协调项目领导者与其成员之间的互动。导师和外部咨询委员会将制定药物发现和评估计划。交付核心将协调必要的药物筛选测定和铅衍生物的生产化合物及其传递到内耳和相关的中枢神经通路，以及听觉 Vestibular 技术核心可验证主要候选耳部治疗药物的功效。目标 2：培养一批关键的受资助研究人员，领导翻译听觉和前庭研究我们将研究听力损失和前庭功能障碍的外周和中枢机制，并确定保留或恢复听力和前庭功能的药物治疗策略，其中包括多种方法我们还为项目负责人提供了出色的指导计划，通过内部导师的高级调查和生物统计支持来补充他们的专业知识作为具有翻译和临床专业知识的外部研究者作为外部导师额外的指导是。由研究核心人员、资助课程和提案审查前的模拟研究部分提供。对研究进展和所有其他中心活动的评估也是优化中心成功的关键。该中心还将受益于内布拉斯加州奥马哈未来蓬勃发展的转化研究环境。计划要求继续扩大该中心，以包括提交研究性新药申请，与 Creighton 服务的患者群体合作进行安全性和有效性研究以及临床试验大学学术医疗中心、天主教健康倡议 (CHI) 卫生系统、BTNRH 和 UNMC。