Administrative Core

行政核心

基本信息

批准号：
10551704
负责人：
Michael R Yeaman
金额：
$ 16.15万
依托单位：
LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-10 至 2028-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10551704
关键词：
Academic Medical Centers Accounting Achievement Administrator Area Benchmarking Bioinformatics Budgets Collaborations Communicable Diseases Communication Communities Computer Models Computer software Consultations Dedications Development Discipline Education Educational workshop Ensure Environment Epigenetic Process Equity Evaluation FAIR principles Faculty Funding Goals Grant Human Resources Infrastructure International Intranet Investigation Journals Learning Life Manuscripts Medical Medical center Mining Modeling Molecular Medicine Monitor National Institute of Allergy and Infectious Disease Network Infrastructure Outcome Performance Policies Postdoctoral Fellow Process Publishing Research Research Personnel Research Project Grants Resource Sharing Resources Role Sepsis Services Students System Systems Biology Technology Teleconferences Time Translational Research United States National Institutes of Health career career development clinical application cost effective data dissemination data management data sharing design digital epigenomics equity, diversity, and inclusion improved innovation meetings multidisciplinary novel outreach pathogen peer networks predictive modeling programs prospective skills success symposium synergism timeline translational applications translational potential

项目摘要

PROJECT SUMMARY/ABSTRACT The current Center proposal, entitled “Systems Epigenomics of Persistent Bloodstream Infection” represents a synergistic approach to understanding the host-pathogen interactions that result in life-threatening bloodstream infections that do not clear on appropriate therapy. A highly innovative and expert team has been assembled to implement a systems-biology strategy that is ideally aligned to achieve NIH / NIAID priorities. A diverse set of expertise, technologies and activities are necessary to efficiently reach our objectives. To effectively manage this integrated research program, we will implement our proven Administrative Network Core (ANC) to interact with each Project and Core. Thus, synergistic collaboration, research efficiency and discovery will be enhanced. The ANC design will afford highly efficient coordination among investigators and Center components, including Projects 1–3, and our Immunomics & Epigenetics (IEC), Bionformatics & Data Management (BDM) and Computational & Predictive Modeling (CPM) Cores. Coordination with Collaborators and Consultants by the ANC further amplifies the programmatic strengths of the Center. The ANC will provide a supportive infrastructure to ensure accomplishment of all Center goals: 1) managing the project financial and personnel resources; 2) facilitating coordination and integration of research Projects, Cores and Advisors; 3) ensuring quality improvement by monitoring of benchmark metrics and logistical optimization; 4) overseeing the solicitation, review, selection and monitoring of Supplemental Research Projects; and 5) promote a positive research environment that is equitable, inclusive and diverse. Thus, the ANC will support the overall Center to inform, coordinate, monitor and advance timely completion of all research goals.

项目概要/摘要当前的中心提案题为“持续性血流感染的系统表观基因组学”，代表了了解导致危及生命的血液的宿主-病原体相互作用的协同方法已经组建了一个高度创新的专家团队来解决无法通过适当治疗清除的感染。实施系统生物学战略，以实现 NIH / NIAID 的优先事项。为了有效地管理这一综合目标，技术和活动是有效实现我们的目标所必需的。研究计划中，我们将实施经过验证的管理网络核心 (ANC) 来与每个项目进行交互，因此，ANC 设计将提高协同合作、研究效率和发现能力。研究人员和中心组成部分（包括项目 1-3 和我们的免疫组学）之间的高效协调和表观遗传学 (IEC)、生物信息学和数据管理 (BDM) 以及计算和预测建模 (CPM) 核心。 ANC 与合作者和顾问的协调进一步增强了该中心的计划优势。 ANC 将提供支持性基础设施，以确保实现所有中心目标：1) 管理项目财务和人力资源；2）促进研究项目、核心和顾问的协调和整合； 3) 通过监控基准指标和物流优化确保质量改进；4) 监督补充研究项目的征集、审查、选择和监督；5) 促进积极的研究；因此，非国大将支持整个中心提供信息、协调、监控并推动所有研究目标的及时完成。