Longitudinal Academic Performance in Children with a History of Neonatal Abstinence Syndrome

有新生儿戒断综合症病史的儿童的纵向学业表现

• 批准号: 10608149
• 负责人: Tammy E Corr
• 金额: $ 19.94万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10608149
• 关键词: 3 year old; Academic Medical Centers; Academic achievement; Accounting; Achievement; Adult; Affect; Age; Biological; Biometry; Caregivers; Caring; Child; Child Welfare; Childhood; Clinical; Clinical Research; Communities; Community Health; Complement; Complex; Conduct Clinical Trials; Crime; Data; Databases; Deterioration; Development; Developmental Delay Disorders; Diagnosis; Disparity; Drug Exposure; Early Intervention; Education; Environment; Epidemiology; Evaluation; Family; Foundations; Future; Generations; Goals; Grant; Health; Health Care Rationing; Illicit Drugs; Incidence; Individual; Infant; Influentials; Information Systems; Intervention; Intervention Studies; Interview; K-Series Research Career Programs; Learning; Link; Measures; Mentorship; Methodology; Methods; Mothers; Neonatal; Neonatal Abstinence Syndrome; Newborn Infant; Nursery Schools; Opioid; Outcome; Parents; Pennsylvania; Performance; Physicians; Policies; Pregnant Women; Problem behavior; Productivity; Public Health; Race; Recording of previous events; Reporting; Research; Research Design; Research Methodology; Research Personnel; Resolution; Resources; Risk; School-Age Population; Schools; Scientist; Services; Severities; Social Environment; Social Welfare; Socioeconomic Factors; Special Education; Symptoms; Syndrome; Testing; Time; Toddler; Training; Translating; United States National Institutes of Health; United States Substance Abuse and Mental Health Services Administration; Withdrawal; achievement test; career development; clinical practice; cost; data warehouse; design; drug exposure in utero; early childhood; effective intervention; experience; health economics; improved; improved outcome; in utero; inattention; neonate; neurodevelopment; opioid epidemic; patient oriented; postnatal; research and development; sex; success

Project Summary/Abstract The objectives of this project are to more thoroughly understand the relationship between neonatal abstinence syndrome (NAS) and longitudinal academic performance. NAS is a withdrawal condition due to in utero drug exposure, most commonly opioids. The syndrome affects more than 32,000 newborns annually in the U.S., and its incidence continues to rise. Researchers report poorer development in toddler and preschool years, higher rates of inattention and behavioral problems, and worse and deteriorating school performance in children with a history of NAS, indicating the effects of NAS may last well beyond the newborn period. However, these existing studies do not sufficiently account for the complex interaction of biologic, health, and socioenvironmental influences on childhood development. Thus, the relationship between NAS and long-term neurodevelopment and academic achievement remains largely unknown. As school achievement is directly associated with adult productivity and negatively correlated with participation in crime, a better understanding of NAS and academic performance is urgently needed to optimize outcomes across a lifetime. This proposal aims to assess the independent relationship between NAS, NAS severity, NAS treatment, in utero drug exposure and longitudinal academic performance after controlling for relevant biologic, health, and socioenvironmental variables; to explore the moderator effects of early community and school resource support on NAS; and to learn how families’ school experiences may explain childhood academic performance. The former aims will be accomplished using an inclusive, uniquely-integrated South Carolinian data warehouse. With this data system, a child with a diagnosis of NAS can be linked with his/her mother, and the dyad can be followed so that a broad range of childhood outcomes can be examined in the context of relevant, influential factors. In addition, through qualitative interviews with parents and guardians of children with a history of NAS followed at a Pennsylvania academic medical center, the project will 1) explore if and how caregivers’ experiences regarding early community and school resource support are related to childhood academic performance and 2) analyze themes that emerge around barriers and facilitators of academic achievement in children with NAS. Under this career development award, the applicant receives training in methodology of data-driven, public health studies and patient-oriented, clinical research design; epidemiology, mixed methodologies, community health, and applying public health principles to clinical practice; and moving research to policy. Successful completion of the project will not only provide data to serve as the foundation for future studies evaluating NAS outcomes and treatment, but, in addition to her training and mentorship plan, will prepare the applicant to become an independent physician-scientist able to conduct clinical trials aimed at improving outcomes of children affected by NAS.

项目概要/摘要 该项目的目标是更彻底地了解新生儿之间的关系 戒断综合症（NAS）和纵向学业表现是一种由于原因而导致的戒断症状。 子宫内药物暴露，最常见的是阿片类药物，该综合征每年影响超过 32,000 名新生儿。 在美国，其发病率持续上升，研究人员报告称，幼儿和学龄前儿童的发育较差。 年，注意力不集中和行为问题的发生率更高，学校表现更差和恶化 有 NAS 病史的儿童，表明 NAS 的影响可能会持续到新生儿期之后。 然而，这些现有的研究并没有充分解释生物学、健康和环境之间复杂的相互作用。 因此，NAS 与长期发展之间的关系。 神经发育和学业成绩仍然很大程度上未知，因为学校成绩是直接的。 与成人生产力相关，与犯罪参与负相关，更好地理解 迫切需要提高 NAS 和学业成绩来优化一生的结果。 该提案旨在评估 NAS、NAS 严重程度、NAS 治疗之间的独立关系， 控制相关生物学、健康和相关因素后，子宫内药物暴露和纵向学业表现 社会环境变量；探索早期社区和学校资源的调节效应 NAS 的支持；并了解家庭的学校经历如何解释儿童的学业表现。 前一个目标将使用包容性、独特整合的南卡罗来纳州数据来实现 有了这个数据系统，被诊断患有 NAS 的孩子可以与他/她的母亲以及孩子建立联系。 可以遵循二元关系，以便可以在相关的背景下检查广泛的童年成果， 此外，通过对有问题的儿童的父母和监护人进行定性访谈。 宾夕法尼亚州学术医疗中心跟踪 NAS 的历史，该项目将 1) 探索是否以及如何 照顾者在早期社区和学校资源支持方面的经验与童年有关 学术表现，2）分析围绕学术障碍和促进因素出现的主题 NAS 儿童的成就。 根据该职业发展奖，申请人将接受数据驱动的、公共的方法论培训 健康研究和以患者为导向的临床研究设计、流行病学、混合方法、社区； 健康，并将公共卫生原则应用于临床实践；并将研究成功应用于政策。 该项目的完成不仅将为未来评估NAS的研究提供数据作为基础 结果和治疗，但是，除了她的培训和指导计划之外，还将帮助申请人做好准备 成为一名独立的医师科学家，能够进行旨在改善结果的临床试验 受 NAS 影响的儿童。