Neuroimaging & Psychophysiology (NIP) Core

神经影像学

• 批准号: 8733662
• 负责人: Emeran A Mayer
• 金额: $ 12.78万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8733662
• 关键词: Agreement; Behavioral; Biomedical Engineering; Brain; Data; Data Collection; Diffusion Magnetic Resonance Imaging; Discipline; Ensure; Functional Magnetic Resonance Imaging; Generations; Grant; Human Resources; Image; Image Analysis; Interstitial Cystitis; Irritable Bowel Syndrome; Laboratories; Magnetic Resonance Imaging; Measurement; Measures; Monitor; Monoclonal Antibody R24; National Center for Complementary and Alternative Medicine; Neurobiology; Neurosciences; Pain; Physiologic pulse; Process; Protocols documentation; Psychophysiology; Quality Control; Radiology Specialty; Reflex action; Research Infrastructure; Research Personnel; Resources; Rest; Science; Services; Sex Characteristics; Stress; TNFRSF5 gene; Technology; Testing; Thick; United States National Institutes of Health; Women' s Health; Writing; base; body-mind; design; diffuse noxious inhibitory control; endophenotype; gray matter; heart rate variability; innovation; mathematical model; morphometry; neuroimaging; novel strategies; repository; shape analysis; success; white matter

The UCLA SCOR Neuroimaging and Psychophysiology (NIP) Core is part of the overarching Neuroimaging Core of the Center for Neurobiology of Stress (CNS NIP Core). It includes investigators from different disciplines and with complementary expertise (mathematical modeling, neuroscience, bioengineering, pain psychophysology). The NIP Core will continue to provide a broad range of neuroimaging and psychophysiology measures to SCOR investigators of Projects 1-3. While closely associated with the larger CNS Neuroimaging Core, the NIP Core will be specifically dedicated to studies proposed under the SCOR grant. The NIP Core builds on the success and extensive expertise and infrastructure developed over the past 10 years and recent collaborative associations with the UCLA Laboratory of Neuroimaging (LONl- brain repository and cortical morphometry), and the UCLA Neuro Radiology group (DTI and white matter tract analysis). Specific aims for the NIP Core include: 1) design and set up of the imaging and psychophysiology protocols, 2) monitoring and ensuring quality control of all data collection for these measures, 3) preprocessing and analysis of imaging and psychophysiology measures, and 4) participation in interpretation and write up of results along with project PIs. It will provide the following protocols and measures: 1) functional MRI (fMRI) measures of brain activity during rest and anticipation of pain, 2) structural MRI assessment of grey matter (cortical thickness and volumetrics) and white matter integrity (DTI), 3) laboratory pain measures of pain sensitivity and heterotropic pain modulation (DNIC), and 4) psychophysiology measures of heart rate variability and pre-pulse modulation of startle. The NIP Core may also serve as a repository and analysis 'hub' for planned inter SCOR imaging studies. The NIP Core has already developed protocols for all the proposed measurements and standardized preprocessing pipelines that facilitate quality control. It also has the statistical expertise for these studies including the analyses for endophenotype discovery in Project 3. The NIP Core Director (J. Labus) is a mathematician with extensive expertise in multiple aspects of imaging analysis and advanced mathematical modeling.

UCLA SCOR神经影像学和心理生理学（NIP）核心是总体神经成像的一部分 胁迫神经生物学中心的核心（CNS NIP核心）。它包括来自不同的调查人员 学科和补充专业知识（数学建模，神经科学，生物工程，疼痛 心理生理学）。 NIP核心将继续提供广泛的神经影像学和 心理生理学措施1-3的SCOR研究人员。虽然与较大的 CNS神经成像核心，NIP核心将专门用于SCOR下提出的研究 授予。 NIP核心建立在成功，广泛的专业知识和基础设施之上 过去10年以及与UCLA神经影像实验室的最近合作协会（Lonl-Brain 存储库和皮质形态计）和UCLA神经放射学组（DTI和白质区域 分析）。 NIP核心的具体目标包括：1）设计和设置成像和心理生理学 协议，2）监视和确保所有数据收集的所有数据收集的质量控制，3） 成像和心理生理学测量的预处理和分析，以及4）参与解释 并写下结果以及PIS PIS。它将提供以下协议和措施：1） 在休息期间和预期疼痛期间的功能性MRI（fMRI）测量，2）结构MRI 评估灰质（皮质厚度和体积）和白质完整性（DTI），3）实验室 疼痛敏感性和异型疼痛调节（DNIC）的疼痛度量，4）心理生理学 心率变异性和惊吓前脉冲调制的度量。 NIP核心也可以用作 存储库和分析“集线器”，用于计划的SCOR成像研究。 NIP核心已经开发 所有提议的测量和标准化预处理管道的协议，以促进质量 控制。它还具有这些研究的统计专业知识，包括分析内表型 项目3中的发现。NIP核心总监（J. Labus）是一位具有广泛专业知识的数学家 成像分析和高级数学建模的多个方面。