Center for Neurovisceral Sciences & Women's Health

神经内脏科学中心

• 批准号: 7847961
• 负责人: Emeran A Mayer
• 金额: $ 28.05万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7847961
• 关键词: Abdominal Pain; Acute; Acute Cystitis; Address; Affect; Affective; Animal Model; Anxiety; Area; Arts; Attenuated; Basic Science; Biological; Biological Assay; Bladder; Bladder Urothelium; Brain; Brain Mapping; CRF receptor type 2; Cell Nucleus; Chemicals; Chemosensitization; Chronic; Chronic stress; Clinical; Clinical Investigator; Collaborations; Colon; Communication; Complex; Conscious; Corticotropin-Releasing Hormone; Corticotropin-Releasing Hormone Receptors; Cues; Data; Development; Diagnosis; Disease; Emotional; Endocrine; Environment; Epidemiology; Epithelial; Estradiol; Estrogen Receptor beta; Estrogen Receptors; Estrogens; Exhibits; Face; Family; Family Felidae; Felis catus; Female; Fetal Development; Fibromyalgia; Functional disorder; Funding; Genes; Grant; Health; Health Care Seeking Behavior; High Prevalence; Homeostasis; Hydrocortisone; Hypothalamic structure; Immune; Impairment; Individual; Inflammation; Interstitial Cystitis; Irritable Bowel Syndrome; Lamina Propria; Lead; Life; Life Stress; Limbic System; Measures; Mediating; Mediator of activation protein; Menstrual cycle; Migraine; Modeling; Molecular; Mood Disorders; Morbidity - disease rate; Mucous Membrane; Mus; Neonatal; Nerve; Nervous system structure; Neurobiology; Neurons; Neurosecretory Systems; Nociception; Nociceptive Reflex; Norepinephrine; Opioid; Oral Contraceptives; Organ; Output; Pain; Pain Disorder; Pathology; Patients; Pelvic Pain; Pelvis; Peptides; Peripheral; Physical environment; Physicians; Pituitary Gland; Plasma; Play; Pontine structure; Pregnancy; Prevalence; Property; Psychological Factors; Quality of life; Rattus; Recording of previous events; Research; Research Personnel; Research Project Grants; Research Support; Risk; Rodent Model; Role; Science; Scientist; Sensory; Services; Sex Bias; Sex Characteristics; Signal Pathway; Signal Transduction; Site; Spinal Cord; Stimulus; Stress; Sympathetic Nervous System; Symptoms; Syndrome; System; T-Lymphocyte; Techniques; Technology; Testing; Translations; Urothelial Cell; Urothelium; Viscera; Visceral; Visceral pain; Water; Woman; Women' s Health; affective modulation of startle; base; biological adaptation to stress; cellular imaging; colorectal distension; conditioned fear; coping; depression; effective therapy; genetic manipulation; health related quality of life; human subject; innovation; interdisciplinary approach; locus ceruleus structure; male; men; neuroimaging; overexpression; programs; psychologic; psychological stressor; receptor; receptor expression; reproductive; research study; resilience; response; sensor; sex; stressor; treatment response; urocortin

DESCRIPTION (provided by applicant): The Center for Neurovisceral Sciences & Women's Health is composed of a cohesive group of clinical investigators and basic scientists with strong independent grant-supported research programs in the interactions between the nervous system and the viscera, with special emphasis on women's health and functional pain disorders, and sex-related differences in stress neurobiology (corticotropin releasing factor [CRF] signaling system). The majority of investigators have a track record of collaborations within a currently funded SCOR. The main focus of the Center is the identification of sex-related factors that play a role in the development, clinical manifestation and treatment response of two common visceral pain syndromes, e.g., irritable bowel syndrome (IBS) and interstitial cystitis (IC). Both disorders are common, occur more commonly in females, appear to show sex differences in treatment responses and cause significant morbidity and impairment in quality of life. The Center has two clinical and two basic science Projects, which closely interdigitate and overlap in terms of thematic, experimental approach and hypotheses. State of the art technology ranging from molecular biological approaches, imaging of cells and the intact brain will be used to study specific aims in these 4 Projects: 1. Differences in central stress circuit responsiveness between women with and without chronic pelvic visceral symptoms (IBS, IC), and in an animal model of chronic stress. 2. Sex differences in mucosal neuro-endocrine-immune interactions in IBS patients, and relationship to symptoms. 3. CRF signaling pathways in stress-related visceral manifestation: sex difference and modulatory role of estrogen beta receptors. 4. The role of the peripheral CRF signaling system in modulating urothelial signaling in cat and rodent models, with an emphasis on sex differences. To facilitate the research, the Center has an Administrative Core and two Scientific Cores (Neuroendocrine Assay, Neuroimaging) and will take advantage of existing NIH-funded core and service facilities on campus, including the UCLA Brain Mapping Center and the GCRC. The Center provides an optimal environment for cooperation and collaboration among its investigators, who already have had a major impact on the field both individually, and as a cohesive group. Thus, the synergy expected from the Center promises to have a large impact upon expanded research into a highly prevalent, but inadequately treated area of women's health.

DESCRIPTION (provided by applicant): The Center for Neurovisceral Sciences & Women's Health is composed of a cohesive group of clinical investigators and basic scientists with strong independent grant-supported research programs in the interactions between the nervous system and the viscera, with special emphasis on women's health and functional pain disorders, and sex-related differences in stress neurobiology (corticotropin releasing factor [CRF] signaling 系统）。大多数调查人员在当前资助的SCOR中都有合作的记录。该中心的主要重点是鉴定与性别相关的因素，这些因素在两种常见的内脏疼痛综合征的发育，临床表现和治疗反应中起作用，例如肠易激综合征（IBS）和间质性膀胱炎（IC）。这两种疾病都是常见的，在女性中更常见，似乎在治疗反应中表现出性别差异，并导致生命质量的大量发病率和障碍。该中心有两个临床和两个基础科学项目，它们在主题，实验方法和假设方面紧密相互互补和重叠。从分子生物学方法，细胞成像和完整大脑的最先进的技术中，将使用这4个项目研究特定目标：1。患有和没有慢性骨盆内脏症状（IBS，IC）的女性中央应力回应的反应性差异，以及在慢性压力的动物模型中的差异。 2。IBS患者中粘膜神经内分泌 - 免疫相互作用的性别差异以及与症状的关系。 3。与应力相关的内脏表现中的CRF信号通路：性别差异和雌激素β受体的调节作用。 4。外围CRF信号系统在调节猫和啮齿动物模型中尿路上皮信号传导中的作用，重点是性别差异。为了促进该研究，该中心具有行政核心和两个科学核心（神经内分泌测定，神经影像学），并将利用校园中现有的NIH资助的核心和服务设施，包括UCLA脑图中心和GCRC。该中心为研究人员之间的合作与协作提供了最佳的环境，其调查人员已经对该领域产生了重大影响。因此，该中心的协同作用有望将扩大的研究扩大到高度流行但不足以治疗的妇女健康领域产生很大的影响。