Biological Analysis Core

生物分析核心

• 批准号: 8914443
• 负责人: JUDY A. VAN DE WATER
• 金额: $ 12.15万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-24 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8914443
• 关键词: Achievement; Address; Area; Biological; Biological Assay; Cells; Cellular Neurobiology; Charge; Consultations; Data; Discipline; Environmental Exposure; Equipment; Experimental Designs; Fragile X Syndrome; Funding; Goals; Heterogeneity; Immune; Immune system; Immunology; Institutes; Intellectual functioning disability; Knowledge; Mental Retardation and Developmental Disabilities Research Centers; Modeling; Molecular; Molecular Neurobiology; Molecular and Cellular Biology; Neurobiology; Neurons; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Services; Supervision; System; Testing; Training; Work; autism spectrum disorder; biobehavior; clinical risk; design; environmental toxicology; experience; immune function; interest; member; neuron development; response

One goal of the UC Davis MIND Institute IDDRC is to more thoroughly address the biological complexity of intellectual and developmental disabilities (IDD), such as fragile X syndrome (FXS) and autism spectrum disorders (ASD). The overall objective of the Biological Analysis Core (BAC) is to facilitate an integrated experimental approach to the study of the molecular and cellular mechanisms of neuronal and immune function, including interactions between the two systems, in the context of IDD. This type of comprehensive core does not currently exist at the MIND Institute or on the UC Davis campus. The BAC is designed to advance and support research on emerging concepts regarding cellular and molecular mechanisms contributing to the risk and clinical heterogeneity of conditions associated with IDD, including variable response to therapy. Services provided will facilitate analyses of neuronal development, direct and indirect interactions between the neuronal and immune systems, and cellular and molecular biology. The BAC will also serve as a liaison to the vast array of resources at UC Davis for studying environmental exposures and extend the core's assays and expertise to testing such exposure effects on immune and neuronal cells for IDDRC projects. Recent achievements in these key areas by investigators included in the proposed IDDRC can now provide the infrastructure needed to advance our understanding of the biologic underpinnings of FXS, ASD, and other IDD conditions. This new core will be a unique resource for the MIND Institute IDDRC and the entire IDDRC network. The BAC is charged with providing core services that address components from each of the MIND Institute IDDRC central themes: Integrated Biobehavioral Characterization of IDD, Environmental Contributions to IDD, and Targeted Treatments for IDD. The BAC is designed to: 1) support the scientific agenda of the IDDRC; 2) provide services and training related to analysis in the areas of cellular and molecular neurobiology and Immunology; 3) increase access to cutting-edge resources in cellular and molecular neurobiology and immunology that will enhance the research of IDDRC investigators; 4) work with each of the IDDRC cores to support the integration and dissemination of services; and 5) work with the Administrative Core to integrate the BAC into the broader context of the UC Davis IDDRC and the national network of NlCHD-funded IDDRCs. The expertise of the BAC director, co-director, and core staff members includes extensive knowledge and experience in immunology, molecular and cellular neurobiology and environmental toxicology in the area of IDD. The key members of the BAC have previously worked together successfully to integrate seemingly disparate disciplines to better understand the neurobiology of ASD. We will develop these successful relationships into a state-of-the-art core to provide users with five tiers of service: 1) consultation in model selection and experimental design; 2) training of users on available equipment; 3) training and supervision in conducting assays of interest where applicable; 4) provision of a battery of assays conducted by core staff; and 5) tailored sets of analyses conducted by core staff. Combinations of service can be designed to match user needs. Assistance with data interpretation will be provided as needed for each tier.

UC Davis Mind Institute IDDRC的目标之一是更彻底地解决的生物学复杂性 智力和发育障碍（IDD），例如脆弱的X综合征（FXS）和自闭症谱系 疾病（ASD）。生物分析核心（BAC）的总体目标是促进综合 研究神经元和免疫的分子和细胞机制的实验方法 在IDD的背景下，功能，包括两个系统之间的交互。这类 目前，综合核心在思维学院或加州大学戴维斯分校校园中不存在。 BAC是 旨在推进和支持有关细胞和分子的新兴概念的研究 导致与IDD相关情况的风险和临床异质性的机制，包括 对治疗的可变反应。提供的服务将促进神经元发展，直接和 神经元和免疫系统以及细胞和分子生物学之间的间接相互作用。 BAC 还将成为加州大学戴维斯分校大量资源的联络人，以研究环境暴露 并将核心的测定和专业知识扩展到测试对免疫和神经元细胞的暴露影响的影响 IDDRC项目。拟议IDDRC中包括的调查人员在这些关键领域的最新成就 现在可以提供我们对FXS生物基础的理解所需的基础设施， ASD和其他IDD条件。这个新核心将成为思维学院IDDRC和 整个IDDRC网络。 BAC负责提供核心服务，以解决每个思想的组成部分 Institute IDDRC中央主题：IDD的综合生物行为表征，环境贡献 到IDD，并针对IDD的目标治疗。 BAC旨在：1）支持的科学议程 IDDRC; 2）提供与细胞和分子神经生物学领域分析相关的服务和培训 和免疫学； 3）增加在细胞和分子神经生物学和分子神经生物学中获得尖端资源的机会 免疫学将增强IDDRC研究人员的研究； 4）将每个IDDRC核心与 支持服务的整合和传播； 5）与行政核心合作以整合 BAC进入UC Davis IDDRC和NLCHD资助的IDDRC国家网络的更广泛背景。 BAC主管，联合主任和核心工作人员的专业知识包括广泛的知识和 免疫学，分子和细胞神经生物学和环境毒理学的经验 IDD。 BAC的主要成员以前已经成功合作，以整合看似集成 不同的学科可以更好地理解ASD的神经生物学。我们将发展这些成功 成为最先进的核心，为用户提供五个服务的核心：1）在模型中进行咨询 选择和实验设计； 2）在可用设备上培训用户； 3）培训和监督 在适用的情况下进行利息的测定； 4）提供由核心人员进行的一系列测定；和 5）由核心人员进行的量身定制的分析集。可以设计服务的组合以匹配用户 需要。每层都需要提供数据解释的帮助。