Core C. Biological and Molecular Analysis Core

核心 C. 生物和分子分析核心

• 批准号: 10682415
• 负责人: JUDY A. VAN DE WATER
• 金额: $ 19.83万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682415
• 关键词: Acceleration; Achievement; Address; Area; Autoimmune Diseases; Behavioral; Biological; Biological Assay; Biology; Brain; California; Cell Surface Receptors; Communicable Diseases; Constitution; Constitutional; Core Facility; Development; Doctor of Philosophy; Down Syndrome; Education; Educational workshop; Ensure; Environmental Risk Factor; Fragile X Syndrome; Functional disorder; Funding; Genes; Genome; Genomics; Goals; Image; Immune; Immune system; Immunologics; Immunology; Individual; Information Systems; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Knowledge; Malignant Neoplasms; Mentors; Methodology; Methods; Molecular; Molecular Analysis; Mus; Nervous System; Neurodevelopmental Disability; Neurologic; Play; Pneumonia; Positioning Attribute; Procedures; Protocols documentation; Research; Research Personnel; Resources; Risk; Role; Series; Services; Signal Pathway; Students; System; Systems Development; Technology; Training; Universities; Water; autism spectrum disorder; cellular imaging; clinical heterogeneity; comorbidity; design; efficacious treatment; epigenomics; genetic risk factor; individualized medicine; interdisciplinary approach; interest; molecular imaging; neuroimmunology; programs; regenerative; research study; response; senior faculty; stem cells

PROJECT SUMMARY – BIOLOGICAL AND MOLECULAR ANALYSIS CORE The present application seeks funding to continue the MIND Institute Intellectual and Developmental Disabilities Research Center (IDDRC) at the University of California, Davis. The IDDRC was launched in 2013 and is the newest of the 14 IDDRCs in the network. The Biological and Molecular Analysis Core (BMAC) is designed to facilitate studies at the cellular and molecular levels investigating the mechanisms by which genetic and environmental risk factors interact to influence brain and immune system development and function in the context of IDD. The BMAC will achieve this goal by addressing three specific aims. Aim 1 is to provide cutting- edge resources and expertise for analyses in neuroimmunology, cellular and molecular imaging, and epigenomics and genomics within the context of IDD research. This aim will be addressed through a tiered approach to services that ranges from full-service support to training of core users to enable independent use of core facilities and resources to access to core facilities and resources for individuals with a strong working knowledge of the technology of interest. The Core will also provide liaison support for researchers with our partner UC Davis cores, including the Genome Center, the Center for Molecular and Genomic Imaging (CMGI), the Mouse Biology Program (MBP), and the Institute for Regenerative Cures (IRC) Stem Cell Core. Aim 2 is to provide education and mentoring at all levels from student to staff to senior faculty in the methods and concepts of immunology, cellular and molecular imaging, and genomics and epigenomics. This aim will be addressed by working with IDDRC investigators to plan their projects and ensure they understand the potential for addressing their aims with the full range of assays and analyses available from the Core, training IDDRC project staff and investigators in the use of selected technologies available in the Core, and offering workshops and seminars illustrating the findings that emerge from the services of the Core. Aim 3 is to support the MIND Institute IDDRC cores and the broader IDDRC network. This aim will be addressed by developing procedures, protocols, and data systems that are informed by, and inform, the other MIND Institute IDDRC cores, and by providing technical and intellectual expertise to support and expand the numerous biological and molecular IDD research studies within the MIND Institute IDDRC and, when appropriate, the entire IDDRC network. The constitution of the BMAC reflects the unique expertise and interdisciplinary approaches for studying IDD at the UC Davis MIND Institute IDDRC, including state-of-the-art methodology in immunology, cellular and molecular imaging, epigenomics, and gene X environmental interactions. The Director of the BMAC is Judy Van de Water, PhD.

项目摘要 - 生物学和分子分析核心 本申请寻求资金来继续思维学院的知识和发展 加州大学戴维斯分校的残疾研究中心（IDDRC）。 IDDRC于2013年启动 并且是网络中14个IDDRC中的最新一个。生物学和分子分析核心（BMAC）是 旨在促进在细胞和分子水平上进行研究的研究，研究了遗传的机制 环境风险因素相互作用，以影响大脑和免疫系统的发展和功能 IDD的上下文。 BMAC将通过解决三个特定目标来实现这一目标。目标1是提供替代 - 边缘资源和专业知识，用于分析神经免疫学，细胞和分子成像以及 IDD研究背景下的表观基因组学和基因组学。这个目标将通过分层解决 从全方位服务支持到核心用户的培训的服务方法 核心设施和资源，可为拥有强大工作的个人提供核心设施和资源 了解感兴趣的技术。核心还将通过我们的研究人员为研究人员提供联络 合作伙伴UC Davis核心，包括基因组中心，分子和基因组成像中心（CMGI）， 小鼠生物学计划（MBP）和再生疗法研究所（IRC）干细胞核心。目标2是 在方法和概念中提供从学生到员工再到高级教师的各个级别的教育和心理 免疫学，细胞和分子成像以及基因组学和表观基因组学。这个目标将由 与IDDRC调查人员合作计划其项目，并确保他们了解解决的潜力 他们的目的是从核心，培训IDDRC项目人员以及 研究人员使用核心中可用的精选技术，并提供讲习班和半手 说明从核心服务中出现的发现。 AIM 3是支持Mind Institute IDDRC 内核和更广泛的IDDRC网络。将通过制定程序，协议和 由另一个思维学院IDDRC核心告知并告知的数据系统，并通过提供技术 以及智力专业知识，以支持和扩展众多生物学和分子IDD研究 在Mind Institute IDDRC中，并在适当的情况下是整个IDDRC网络。 BMAC的配置 反映了UC Davis Mind Institute研究IDD的独特专业知识和跨学科方法 IDDRC，包括免疫学，细胞和分子成像，表观基因组学以及 基因X环境相互作用。 BMAC的主任是Judy Van de Water博士。