The Molecular Biology of Neurosensory Systems

神经感觉系统的分子生物学

• 批准号: 8921227
• 负责人: Shelley D Smith
• 金额: $ 100.52万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-05 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8921227
• 关键词: Molecular; Biology; Neurosensory; Systems

DESCRIPTION (provided by applicant): The goal of the Center for the Molecular Biology of Neurosensory Systems is to build a productive group of researchers investigating the mechanisms of neurosensory development which will provide the foundations for new treatments. Advances in developmental neuroscience are essential to the discovery of effective therapies, as evidenced by the NEI's Audacious Goal, to "Regenerate Neurons and Neural Connections", and NIDCD's Priority Area 1 for Hearing and Balance, "Understanding Normal Function". To accomplish this, three research institutions have been working together to establish excellence in this field by funding and mentoring new faculty members to enable them to develop independent research careers, and by creating core facilities offering state of the art technical support. Of our eight junior investigators funded in Phase I, seven have been promoted, some with tenure, and are now serving as mentors themselves. In Phase 11, our Center is expanding to encompass developmental neuroscience and translational research projects. New technologies are being added to our cores, and the cores conduct research to augment to their capabilities. The Center has instituted new mechanisms allowing our members to access additional core facilities as the complexity of research increases. This is resulting in interactive researchers who have obtained over $20,000,000 in new research funds and are publishing independently and together. Utilization of our core facilities extends beyond our Center, and they are major resources for researchers in many specialties who are studying molecular genetic mechanisms. In Phase III, we focus further on the core facilities, expanding and consolidating them to offer a more complete array of services. An experienced Program Coordinator will coordinate the operation of the cores, making them even more efficient and self-sustaining so that the actual funding per core can be decreased. We will continue to fund new researchers and will provide an enhanced mentoring core. Our Center has benefited from an exceptionally talented and engaged External Advisory Committee, and the addition of an internal Steering Committee will provide more immediate advice for the mentoring program and the overall administration of the Center.

描述（由申请人提供）：神经感觉系统分子生物学中心的目标是建立一个有效的研究人员，研究神经感觉开发的机制，该机制将为新疗法提供基础。发育神经科学的进步对于发现有效的疗法至关重要，这是NEI大胆的目标，即“再生神经元和神经联系”，以及NIDCD的优先区域1以进行听力和平衡，“理解正常功能”。为此，三个研究机构一直在通过资助和指导新的教职员工的资金和指导他们发展独立的研究职业，并创建提供最先进的技术支持状态的核心设施来在这一领域中建立卓越。在第一阶段资助的八名初级调查人员中，有七名被提升，其中一些是任期的，现在正在担任导师。在第11阶段，我们的中心正在扩展到涵盖发展性神经科学和转化研究项目。正在将新技术添加到我们的核心中，核心进行研究以增强其能力。该中心建立了新的机制，使我们的成员能够随着研究的复杂性的增加而获得其他核心设施。这导致互动研究人员获得了超过20,000,000美元的新研究资金，并共同出版。我们核心设施的利用范围超出了我们的中心，这是许多正在研究分子遗传机制的专业研究人员的主要资源。在第三阶段，我们进一步关注核心设施，扩大和巩固它们，以提供更完整的服务。经验丰富的程序协调员将协调核心的运行，使它们更加高效，自我维持，以便可以减少每个核心的实际资金。我们将继续为新研究人员提供资金，并提供增强的指导核心。我们的中心受益于一个非常有才华和参与的外部咨询委员会，内部指导委员会的增加将为指导计划和中心的整体管理提供更直接的建议。