Childhood Diabetes Clinical & Molecular Research Training Program

儿童糖尿病临床

• 批准号: 8664579
• 负责人: DAVID B ALLEN
• 金额: $ 12.76万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8664579
• 关键词: Childhood; Clinical; Diabetes Mellitus; Molecular; Research Training; Training Programs

DESCRIPTION (provided by applicant): The goal of the Childhood Diabetes Clinical & Molecular Research Training Program (CDCMRT) is to train MD pediatric endocrinology fellows and PhD fellows for academic research careers in type 2 diabetes, insulin resistance, obesity and fitness in children. Insulin resistance, usually associated with obesity and increasingly leading to overt diabetes, has become a major health problem in children. Research fellows in this program have the opportunity to begin a career in molecular and cellular research in internationally recognized laboratories engaged in biochemical and molecular genetic studies of pancreatic islet biology, insulin sensitivity, or whole body pathophysiology studying human metabolism, energy expenditure, adiposity, fitness, androgen excess and the metabolic syndrome in ethnically diverse children and adolescents. Objectives include 1) establishment of a high quality and productive research project, 2) development of a progressive record of publication in respected research journals, 3) application for and procurement of extramural grant funding during fellowship, and 4) pursuit of academic careers in childhood diabetes, insulin resistance and obesity research by a minimum of 50% of the graduates of this program. To achieve these objectives, a curriculum has been developed in collaboration with the NIH-funded University of Wisconsin Institute for Clinical and Translational Research Program (ICTR) to provide training in diabetes and insulin resistance, research techniques, statistics and study design, medical ethics, scientific writing and presentation skills, and preparation of grant applications. CDCMRT research opportunities involve clinical, translational, and basic science activities that have been both independently and collaboratively successful and are directed towards the study of diabetes and insulin resistance diseases. The continually rising burden of diabetes and other obesity-related metabolic disorders, the strong record of accomplishment of our first group of T32-supported fellows and recognition of a national shortage of basic science researchers and pediatric endocrinologists with childhood obesity and type 2 diabetes training prompt us to seek continued funding for the CDCMRT program. The University of Wisconsin Center for the Study of Diversity in Health Care will assist the CDCMRT in recruiting under-represented minority trainee candidates. Given the opportunity, the CDCMRT program will continue to provide trainees with a comprehensive mentored research training experience that will prepare them for innovative, productive research careers in childhood diabetes, insulin resistance and obesity.

描述（由申请人提供）：儿童糖尿病临床与分子研究培训计划（CDCMRT）的目标是培训MD儿科内分泌学研究员和博士学位研究生，用于2型糖尿病，胰岛素抵抗，肥胖，儿童的肥胖症和健身的学术研究生涯。胰岛素抵抗通常与肥胖有关，并越来越多地导致明显的糖尿病，已成为儿童的主要健康问题。该计划中的研究人员有机会在从事胰岛生物学，胰岛素敏感性或整个身体病理生理学研究的国际公认的实验室中开始从事分子和细胞研究的职业，或者从事生物学和分子遗传学研究，研究了人体生物生理学研究，对人类的代谢，掺杂，掺杂，掺杂，掺杂，脂肪，脂肪，适应性，及格及其多种多样的综合体系，并具有多种多样的合成。目的包括1）建立高质量和生产性研究项目，2）在尊敬的研究期刊中发展出逐步出版的记录，3）在研究金期间的申请和采购，以及4）在儿童期糖尿病，胰岛素抵抗和肥胖研究中追求该计划的毕业生50％的胰岛素抵抗和肥胖研究。为了实现这些目标，已经与由NIH资助的威斯康星大学临床与转化研究研究所（ICTR）合作开发了一项课程，以提供糖尿病和胰岛素抵抗，研究技术，统计技术和研究设计，医学伦理学，科学写作和演讲能力以及赠款应用程序的培训。 CDCMRT的研究机会涉及独立和协作成功的临床，转化和基础科学活动，并致力于研究糖尿病和胰岛素抵抗疾病。糖尿病和其他与肥胖相关的代谢疾病的负担不断增加，这是我们第一组T32支持的研究员完成的良好记录，并认识到全国性的基础科学研究人员和儿童肥胖症儿童肥胖症和2型糖尿病培训的缺乏，并促使我们继续为CDCMRT寻求筹集资金。威斯康星大学医疗保健多样性研究中心将帮助CDCMRT招募代表性不足的少数民族培训人员候选人。鉴于机会，CDCMRT计划将继续为受训者提供全面的指导研究培训经验，这将为他们提供创新，富有生产力的研究生涯，从而为儿童糖尿病，胰岛素抵抗和肥胖做好准备。