EVALUATION OF GH EFFECTS ON REE AND BODY COMPOSITION OF CHILDREN WITH PWS

评估 GH 对 PWS 儿童的 REE 和身体成分的影响

• 批准号: 6121717
• 负责人: DAVID B ALLEN
• 金额: $ 3.35万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6121717
• 关键词: Prader Willi syndrome; basal metabolism; bioenergetics; body composition; bone density; cardiovascular disorder; child (0-11); child physical development; clinical research; clinical trial phase I; disease /disorder proneness /risk; human subject; human therapy evaluation; muscle strength; nutrient intake activity; nutrition related tag; respiratory function; somatotropin

We seek support to investigate the anabolic effects of growth hormone (GH) on body composition in children with a genetic form of obesity, Prader-Willi Syndrome (PWS). We have begun to study the metabolic effects of GH on body composition including linear growth rate, bone density, nutrient intake, and cardiovascular risk factors including resting energy expenditure, lean body mass and percent body fat, muscle strength and agility, pulmonary function, as well as carbohydrate and lipid metabolism. This patient population provides a model with known risk factors for genetic obesity, and metabolic consequences of growth hormone deficiency. Recent investigations have shown anabolic effects of GH improving body composition, while decreasing obesity and other cardiovascular risk factors. We have been awarded peer reviewed funding for a comprehensive controlled study, which provides a unique opportunity to engage in multi-disciplinary clinical research. However, since the time of this clinical grant award, we have added an additional facet to the study: the measurement of resting energy expenditure (REE). Sufficient funds have been obtained to accomplish the majority of study objectives, but not for REE measurements. The measurement of REE utilizing respiratory quotient measurements contributes substantial scientific value to the study protocol, and will be directly applicable to future investigations of metabolic effects of GH and other anabolic hormones on body composition. This assessment will provide important information about factors leading to abnormal body composition in PWS, while further preparing the fellow to conduct important future investigations of the metabolic effects of GH on body composition and obesity.

我们寻求支持，研究生长激素（GH）对肥胖，prader-willi综合征（PWS）儿童身体组成的合成代谢作用。 我们已经开始研究GH对人体成分的代谢作用，包括线性生长速率，骨密度，养分摄入量以及心血管危险因素，包括静息能量消耗，瘦体重和体内脂肪百分比，肌肉力量和敏捷性，肺功能，肺功能以及碳水化合物以及碳水化合物和脂质代谢。 该患者人群提供了一个模型，具有遗传肥胖的已知风险因素，以及生长激素缺乏症的代谢后果。 最近的研究表明，GH改善人体成分的合成代谢作用，同时降低肥胖症和其他心血管危险因素。我们被授予同行评审的资金进行全面的对照研究，该研究为参与多学科临床研究提供了独特的机会。 但是，自从获得临床赠款奖的时间以来，我们为研究添加了一个额外的方面：静息能量支出（REE）的测量。 已经获得了足够的资金来实现大多数研究目标，但不能用于REE测量。 REE利用呼吸商测量值的测量为研究方案贡献了实质性的科学价值，并将直接适用于对GH和其他合成代谢激素对人体组成的代谢作用的未来研究。 这项评估将提供有关导致PW中身体异常组成的因素的重要信息，同时进一步准备了该研究员对GH对身体组成和肥胖的代谢影响的重要研究。