EVALUATION OF GH EFFECTS ON REE AND BODY COMPOSITION OF CHILDREN WITH PWS

评估 GH 对 PWS 儿童的 REE 和身体成分的影响

• 批准号: 6282089
• 负责人: DAVID B ALLEN
• 金额: $ 2.43万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6282089
• 关键词: Prader Willi syndrome; basal metabolism; bioenergetics; body composition; bone density; cardiovascular disorder; child (0-11); child physical development; clinical research; clinical trial phase I; disease /disorder proneness /risk; human subject; human therapy evaluation; muscle strength; nutrient intake activity; nutrition related tag; respiratory function; somatotropin

We seek support to investigate the anabolic effects of growth hormone (GH) on body composition in children with a genetic form of obesity, Prader-Willi Syndrome (PWS). We have begun to study the metabolic effects of GH on body composition including linear growth rate, bone density, nutrient intake, and cardiovascular risk factors including resting energy expenditure, lean body mass and percent body fat, muscle strength and agility, pulmonary function, as well as carbohydrate and lipid metabolism. This patient population provides a model with known risk factors for genetic obesity, and metabolic consequences of growth hormone deficiency. Recent investigations have shown anabolic effects of GH improving body composition, while decreasing obesity and other cardiovascular risk factors. We have been awarded peer reviewed funding for a comprehensive controlled study, which provides a unique opportunity to engage in multi-disciplinary clinical research. However, since the time of this clinical grant award, we have added an additional facet to the study: the measurement of resting energy expenditure (REE). Sufficient funds have been obtained to accomplish the majority of study objectives, but not for REE measurements. The measurement of REE utilizing respiratory quotient measurements contributes substantial scientific value to the study protocol, and will be directly applicable to future investigations of metabolic effects of GH and other anabolic hormones on body composition. This assessment will provide important information about factors leading to abnormal body composition in PWS, while further preparing the fellow to conduct important future investigations of the metabolic effects of GH on body composition and obesity.

我们寻求支持研究生长激素的合成代谢作用 （GH）关于肥胖遗传形式的儿童的身体成分， Prader-Willi综合征（PWS）。 我们已经开始研究代谢 GH对人体成分的影响，包括线性生长速率，骨骼 密度，养分摄入量和心血管危险因素，包括 静止的能量消耗，瘦体重和体内脂肪百分比，肌肉 强度和敏捷性，肺功能以及碳水化合物和碳水化合物和 脂质代谢。 该患者群体提供了一个已知的模型 遗传肥胖的危险因素和生长的代谢后果 激素缺乏。 最近的调查显示了合成代谢作用 GH改善身体成分的同时减少肥胖和其他 心血管危险因素。 我们被授予同行评审的资金，以全面 对照研究，提供了一个独特的机会来参与 多学科临床研究。 但是，由于这个时期 临床赠款奖，我们为这项研究添加了一个额外的方面： 静息能量支出（REE）的测量。 足够的资金 已获得实现大多数研究目标的获得 不需要REE测量。 利用呼吸道的REE的测量 商测量值贡献了实质性的科学价值 研究方案，将直接适用于未来的调查 GH和其他合成代谢激素对人体的代谢作用 作品。 该评估将提供有关的重要信息 导致PWS异常身体组成异常的因素，而进一步 准备同胞对未来的重要调查 GH对身体成分和肥胖的代谢作用。