ECOG-ACRIN Biorepositories to Support NCTN

ECOG-ACRIN 生物样本库支持 NCTN

基本信息

批准号：
8913372
负责人：
STANLEY R. HAMILTON
金额：
$ 228.51万
依托单位：
ECOG-ACRIN MEDICAL RESEARCH FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-29 至 2020-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8913372
关键词：
Adult American College of Radiology Imaging Network Arts Biological Biological Markers Blood Blood Cells Body Fluids Boston Brain Neoplasms Breast Cancer Center Cancer Patient Cataloging Catalogs Center for Translational Science Activities Chicago Clinic Clinical Clinical Research Clinical Sciences Clinical Treatment Clinical Trials Clinical Trials Network Collaborations Collection Correlative Study DNA Dana-Farber Cancer Institute Data Databases Development Doctor of Medicine Doctor of Philosophy Early Diagnosis Eastern Cooperative Oncology Group Enrollment Ensure Environment Evolution Focus Groups Funding Future Gastrointestinal tract structure Genitourinary system Goals Grant Gray unit of radiation dose Gynecologic Head Head and neck structure Hematologic Neoplasms Housing Human Image Immunologic Monitoring Information Technology Laboratories Lead Link Liquid substance Liver Lung Lymphoma Malignant - descriptor Malignant Neoplasms Medical center Medicine Methodology Modification Molecular Multiple Myeloma National Clinical Trials Network Non-Malignant Pathologic Pathologist Pathology Patients Performance Phase Principal Investigator Process Proteins RNA Reagent Records Reproductive system Research Research Infrastructure Research Personnel Resources Science Services Skin Solid Specimen Structure Therapeutic Therapeutic Clinical Trial Thyroid Gland Tissues Translational Research Treatment outcome United States National Institutes of Health Universities University of Pittsburgh Cancer Institute University of Texas M D Anderson Cancer Center advanced disease anticancer research base biobank cancer care cancer prevention data management innovation leukemia tissue bank leukemia/lymphoma meetings molecular pathology novel operation professor programs public health relevance soft tissue statistics treatment trial tumor

项目摘要

DESCRIPTION (provided by applicant): ECOG-ACRIN (EA) represents the merger of ECOG and ACRIN to form a cooperative group focused on practice-changing clinical and translational research across the cancer care continuum from cancer prevention and early detection, through the management of advanced disease and its impact. This application is to support the infrastructure and banking operations for one of the five NCI National Clinical Trials Network (NCTN) Biospecimen Banks. Together, the NCTN Banks will form an integrated network and will collaborate with each other and with affiliated NCTN Group Statistics and Data Management Centers, Operations Offices, other NCTN units, NCI-sponsored programs and investigators, and the NCI. The goal is to ensure the collection, storage, and distribution of well-annotated human biospecimens, procured from cancer patients participating in NCI-funded NCTN Phase III and large Phase II clinical treatment trials. EA's Specific Aims are: 1) To collect, process, store, catalog, and distribute malignant and non-malignant tissues, cells, blood, and other fluid specimens and their derivatives (DNA, RNA, and protein) from patients enrolled in EA clinical trials following the NCI's "Best Practices for Biospecimen Resources" and to link the specimens to relevant clinical, pathologic, and molecular data within the NCTN program; 2) To develop and utilize both routine and innovative biospecimen resources that will aid in the successful completion of NCTN-supported clinical trials based on integral biomarkers and of related correlative studies to promote the development of novel biomarker-driven personalized cancer therapeutic strategies; 3) To develop capabilities for performing classic and molecular methodologies on tissue, cell, blood, and other body fluid-based specimens from EA clinical trial patients, including planned future consolidation of specimen-based functions, and provide expert interpretation of the findings in close collaboration with the investigators leading the related NCTN-supported clinical trials; and 4) To assist investigators outside and within the NCTN to access biospecimens for research via IT Navigator and NCTN Biospecimen "front door" services, and to participate actively in, lead, and coordinate the activities of the NCI Grou Banking Committee (GBC), the NCI Experimental Therapeutics Clinical Trials Network (ETCTN), and other National Institutes of Health (NIH)/NCI-supported specimen banking organizations.

描述（由应用程序提供）：ECOG-ACRIN（EA）代表ECOG和ACRIN的合并，形成了一个侧重于改变练习的临床和翻译研究的教练组，并通过治疗晚期疾病及其影响，从而从癌症预防和早期发现继续进行癌症护理。该申请是为五个NCI国家临床试验网络（NCTN）Biospecimen Banks之一的基础设施和银行业务提供支持。 NCTN银行将共同组成一个集成的网络，并将相互合作，并与NCTN集团统计和数据管理中心，运营办公室，其他NCTN单位，NCI赞助的计划和研究人员以及NCI合作。目的是确保从参与NCI资助的NCTN III和大型II期临床治疗试验的癌症患者中采购的良好人类生物循环的收集，存储和分布。 EA的具体目的是：1）收集，处理，存储，目录和分布恶性和非恶性组织，细胞，血液和其他液体标本及其衍生物及其衍生物（DNA，RNA和蛋白质），该患者从NCI的临床试验中纳入了临床试验的临床临床和摩尔群的最佳临床实践，并与临床的临床进行了摩擦，并与临床的生物效果相关的临床和摩尔群的临床疗法，并将其相关的临床发展效果与临床相关。程序; 2）开发和利用常规和创新的生物测量资源，这些资源将有助于成功完成基于整体生物标志物和相关研究的NCTN支持的临床试验，以促进新型生物标志物驱动的个性化个性化的个性化癌症治疗策略的发展； 3）开发能够在EA临床试验患者的组织，细胞，血液和其他基于体液的标本上执行经典和分子方法的能力，包括计划的基于标本的功能的未来巩固，并与领导研究人员与领导NCTN相关NCTN支持的NCTN支持的临床临床试验的研究结果进行了专家解释；和4）帮助NCTN外部和内部的调查人员通过IT导航器和NCTN Biospecimen“前门”服务访问生物测量，并积极参与NCI Grou Banking委员会（GBC）的活动，NCI实验疗法临床试验网络（ETCTN）和其他Instrient-nih Intiuts-nih Intiuts-nih IniTITS，标本银行组织。