ECOG-ACRIN Biospecimen Bank to Support NCTN

ECOG-ACRIN 生物样本库将支持 NCTN

基本信息

批准号：
10378704
负责人：
STANLEY R. HAMILTON
金额：
$ 403.6万
依托单位：
ECOG-ACRIN MEDICAL RESEARCH FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-29 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10378704
关键词：
American College of Radiology Imaging Network Basic Science Biological Biological Markers Biological Specimen Banks Biometry Blood Body Fluids Bone Marrow Boston Brain Neoplasms Cancer Center Cancer Patient Cancer Research Network Catalogs Cells Chicago Clinic Clinical Clinical Research Clinical Sciences Clinical Treatment Clinical Trials Collaborations Collection Colorado Continuity of Patient Care Correlative Study Cytology Dana-Farber Cancer Institute Data Databases Department chair Development Disease Doctor of Philosophy Early Diagnosis Eastern Cooperative Oncology Group Enrollment Ensure Focus Groups Funding Future Gastrointestinal Neoplasms Goals Gynecologic Head Head and neck structure Hematologic Neoplasms Human Image Immunologic Monitoring Immunologics Information Technology Infrastructure Laboratories Link Liquid substance Liver Lung Lymphoma Malignant - descriptor Malignant Neoplasms Mammary Neoplasms Medicine Methodology Modification Molecular Multiple Myeloma National Clinical Trials Network Neoplasm Circulating Cells New York Non-Malignant Pathologic Pathology Patients Performance Principal Investigator Process Proteins RNA Records Reproductive system Research Research Personnel Resources Sampling Science Services Site Skin Specimen Therapeutic Thyroid Gland Tissues Translational Research Treatment outcome United States National Institutes of Health Universities University of Texas M D Anderson Cancer Center advanced disease base biobank biomarker-driven cancer care cancer prevention cell free DNA clinically relevant data management exosome imaging science innovation leukemia leukemia/lymphoma molecular pathology novel novel marker operation peripheral blood predictive marker professor programs repository screening soft tissue support network treatment trial tumor urogenital tract

项目摘要

Project Summary ECOG-ACRIN (EA) represents the merger of ECOG and ACRIN to form a cooperative group focused on practice-changing clinical and translational research across the cancer care continuum from cancer prevention and early detection, through the management of advanced disease and its impact. This application is to support the infrastructure and banking operations for the EA Central Biorepository and Pathology Facility (EA CBPF), a highly collaborative, productive and impactful biorepository resulting from the consolidation of five NCI National Clinical Trials Network (NCTN) Biospecimen Banks, including one currently finalizing transition. The consolidation of biorepository activities into EA CBPF has significantly impacted operations by centralizing and continuing the standard and innovative biorepository activities and enhancing capabilities to develop novel predictive biomarkers and therapeutic approaches in cancer. EA CBPF will continue being assisted by the EA Biostatistics and Data Management Center (BDMC), Operations Offices, other NCTN units, NCI-sponsored programs and investigators, and the NCI. The goal of EA CBPF is to ensure the collection, storage, and distribution of well-annotated human biospecimens, procured from cancer patients participating in the NIH/NCI and NCTN NCI-funded clinical treatment trials. EA CBPF's Aim 1 is to collect, process, store, catalog, and distribute malignant and non-malignant tissues, cells, blood, and other fluid specimens and their derivatives (e.g., tissue-derived and cell free DNA and RNA, proteins, exosomes and circulating tumor cells) from patients enrolled in EA clinical trials following the NCI's “Best Practices for Biospecimen Resources” and to link the specimens to relevant clinical, pathologic, immunological and molecular data within the NCTN program; Aim 2 is to develop and utilize both routine and innovative biospecimen resources that will aid in the successful completion of NCTN-supported clinical trials based on integral biomarkers and of related correlative studies to promote the development of novel biomarker-driven personalized cancer therapeutic strategies; Aim 3 is to develop capabilities for performing classic and molecular methodologies on tissue, cell, blood, and other body fluid–based specimens from EA clinical trial patients, including planned future consolidation of specimen-based functions, and provide expert interpretation of the findings in close collaboration with the investigators leading the related NCTN- supported clinical trials; and Aim 4 is to assist investigators outside and within the NIH/NCI NCTN and NCORP to access biospecimens for research by participating actively, and leading efforts in high priority programs such as the NCTN Navigator services and the Center for Immune Monitoring of Cancer (CIMAC), as well as contributing actively to the biorepository harmonization activities of the NCI Group Banking Committee (GBC) and NIH/NCI-supported specimen banking organizations.

项目摘要 ecog-acrin（ea）代表ECOG和ACRIN的合并，形成了一个集中的合作群体在改变癌症的癌症护理连续体的临床和翻译研究中通过管理晚期疾病及其影响，预防和早期检测。此应用程序是为了支持EA中央生物验证和病理的基础设施和银行业务设施（EA CBPF），这是一个高度协作，富有成效且有影响力的生物座席，由合并五个NCI国家临床试验网络（NCTN）Biosecimen Banks，其中包括目前最终化过渡。将生物座席活动巩固到EA CBPF中已显着影响通过集中和继续进行标准和创新的生物座席活动，并增强运营开发癌症中新型预测生物标志物和治疗方法的能力。 EA CBPF会继续得到EA生物统计学和数据管理中心（BDMC）的协助，运营办公室，其他NCTN单位，NCI赞助的计划和研究人员以及NCI。 EA CBPF的目标是确保从癌症患者那里购买的良好人类生物测量的收集，存储和分布参加NIH/NCI和NCTN NCI资助的临床治疗试验。 EA CBPF的目标1是收集，处理，存储，目录和分布恶性组织，细胞，血液和其他流体标本及其衍生物（例如，组织衍生和细胞的无细胞DNA和RNA，蛋白质，外泌体以及 NCI的“最佳实践生物循环资源”，并将标本与相关的临床，病理，免疫学和 NCTN程序中的分子数据；目标2是开发和利用常规和创新生物测量资源将有助于成功完成基于NCTN支持的临床试验整体生物标志物和相关的相关研究，以促进新型生物标志物驱动的发展个性化癌症治疗策略； AIM 3是开发执行经典和的能力来自EA临床试验的组织，细胞，血液和其他体液标本的分子方法患者，包括计划的基于标本功能的未来合并，并提供专家与领导相关NCTN支持的调查人员密切合作对发现的解释临床试验；目标4是在NIH/NCI NCTN和NCORP外部和内部协助调查人员通过积极参与来访问生物测量，以进行研究，并在高优先级计划中领导努力作为NCTN导航器服务和癌症免疫监测中心（CIMAC）以及积极贡献NCI集团银行委员会（GBC）的生物统一协调活动以及NIH/NCI支持的标本银行组织。