Tissue Procurement and Banking Facility

组织采购和银行设施

• 批准号: 7695937
• 负责人: STANLEY R. HAMILTON
• 金额: $ 21.15万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-28 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7695937
• 关键词: Accounting; Attention; Basic Science; Benign; Biopsy; Cancer Center Support Grant; Caring; Cataloging; Catalogs; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Compatible; Computer software; Core Facility; Custom; DNA analysis; Data; Databases; Diagnostic; Disorder by Site; Documentation; Drug or chemical Tissue Distribution; Epidemiology; Equilibrium; Evaluation; Excision; Extramural Activities; Facility Controls; Family history of; Funding; Future; Goals; Head; Hematopathology; Individual; Informatics; Institution; Intranet; Laboratories; Laboratory Assistant; Location; Maintenance; Malignant Neoplasms; Medicine; Methodology; Monitor; National Cancer Institute; Online Systems; Operating Rooms; Organ; Outcome; Pathologist; Pathology; Patients; Peer Review; Population; Procedures; Proteins; Protocols documentation; Quality Control; RNA; Registries; Reproduction spores; Research; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Retrieval; Secure; Services; Site; Specialist; Specimen; Surgical Pathology; System; Testing; Therapeutic; Time; Tissue Banking; Tissue Banks; Tissue Procurements; Tissues; Tumor-Associated Process; University of Texas M D Anderson Cancer Center; base; human subject; human tissue; improved; neoplastic; programs; quality assurance; repository; tissue processing; tool; tumor

The Tissue Procurement and Banking Facility (TPBF) provides all basic science and clinical investigators at MDACC with access to human tissues that have been removed by therapeutic resection or biopsy. The goals of the shared resource are to: 1) maintain a flexible specialized tissue-procurement resource that provides requesting investigators efficient and expeditious delivery to requesting investigators of freshlyobtained well-characterized and custom-processed tumor and control tissue from patients in operating rooms, procedure rooms and clinics; 2) maintain and improve a centralized institution-wide tissue procurement and banking core facility that provides specimens according to NCI Best Practices for Biospecimen Resources and compatible with current, emerging, and anticipated methodologies for analysis of DNA, RNA and protein; 3) interface with other institutional databases to enhance the intranet-based database so it will provide epidemiology, family history, patient treatment, and patient outcome; 4) support the individual programmatically administered and funded satellite tissue banks operational within the institution, including those maintained by disease sites, SPOREs and P01s; and 5) meet the federal, state and institutional regulatory requirements for use of human tissue in research and protection of human subjects. The Facility occupies 379 sq ft and 187 sq ft within the two Surgical Pathology suites and has a separate 2,500 sq ft secure, monitored, environmentally-controlled facility with 21 freezers. Additional tissue processing rooms for TPBF use are located in each clinic with procedure rooms. The TPBF is staffed with a Director, Laboratory Manager, 2 Tissue Procurement Specialists, 2 Tissue Laboratory Assistants, a Data Coordinator, and a Clinical Research Coordinator. During the previous funding period, 154,122 specimens were collected from 21,902 cases. A total of 124,378 specimens were distributed with 87% provided to 14 peer-reviewed funded satellite banks, 5% to peer-reviewed funded individual investigators, 7% to non-peer reviewed funded individual investigators, and 1% to non-peer reviewed funded satellite banks. Individual investigators can obtain tissue specimens from satellite banks and the TPBF. TPBF services were used by 66 investigators from 19 of the 21 CCSG programs. 65% of the individual users had peer-reviewed funding and accounted for 40% of the utilization by individual users. Future plans are focused on interfacing with clinical, epidemiologic, tumor registry, and protocol databases to enhance specimen annotation through the TissueStation and ResearchStation software initiatives; quality control/quality assurance including evaluation with the Biospecimen Repository Evaluation Tool (BRET) from the National Cancer Institute; completion of compliance with the NCI Best Practices for Biospecimen Resources that were issued in June of 2007 and Clinical Laboratory Improvement Act of 1988, and continuing to expand capacity to meet research needs.

组织采购和银行设施（TPBF）为所有基础科学和临床研究者提供 MDACC可以通过治疗切除或活检去除人体组织。这 共享资源的目标是：1）保持灵活的专业组织采购资源 向请求调查人员提供高效，迅速的交付 从患者手术中的特征和定制的肿瘤和控制组织 房间，程序室和诊所； 2）维护和改善集中式机构范围内的组织 根据NCI的最佳实践提供标本的采购和银行核心设施 生物循环资源，并与当前，新兴和预期的方法兼容用于分析的方法 DNA，RNA和蛋白质； 3）与其他机构数据库的接口以增强基于Intranet的 数据库将提供流行病学，家族史，患者治疗和患者预后； 4）支持 个人通过编程管理和资助的卫星组织库在 机构，包括由疾病部位，孢子和P01维护的机构； 5）会见联邦政府 以及在人类研究和保护人类组织中使用人体组织的机构监管要求 主题。该设施在两个手术病理套件内占据379平方英尺和187平方英尺，有一个 单独的2,500平方英尺安全，受监控，环境控制的设施，带有21个冰柜。其他组织 TPBF使用的加工室位于每个诊所中，带有程序室。 TPBF配备了 2个组织采购专家，2个组织实验室助手，一个数据 协调员和临床研究协调员。在上一个资金期间，154,122个标本 从21,902例案件中收集。总共分发了124,378个标本，提供87％的标本为14 经过同行评审的资助卫星银行，为同行评审的个人调查人员提供5％ 审查了经过资助的个人调查人员，1％降至未审查的经过资助的卫星银行。个人 研究人员可以从卫星库和TPBF获取组织标本。 TPBF服务使用 21个CCSG计划中的19名调查人员。 65％的个人用户进行了同行评审的资金 并占个人用户利用率的40％。未来计划的重点是与 临床，流行病学，肿瘤注册表和方案数据库，以增强标本注释 组织和研究组织软件计划；质量控制/质量保证包括评估 带有国家癌症研究所的生物测量存储库评估工具（BRET）；完成 遵守2007年6月发行的生物循环资源的NCI最佳实践和 1988年的临床实验室改进法案，并继续扩大满足研究需求的能力。