Novel Analytical Tools for 3 Dimensional Imaging Studies on Spinal Manipulation

用于脊柱操作 3 维成像研究的新型分析工具

• 批准号: 8690774
• 负责人: NOZOMU INOUE
• 金额: $ 35.99万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8690774
• 关键词: 3-Dimensional; Basic Science; Biomechanics; Cadaver; Clinical; Clinical Research; Communities; Complementary and alternative medicine; Complex; Computer software; Data; Development; Dimensions; Disease; Effectiveness; Facet joint structure; Funding; Future; Geometry; Goals; Human; Image; Individual; Internet; Intervertebral disc structure; Lateral; Low Back Pain; Lumbar Disc Degenerative Disorder; Magnetic Resonance Imaging; Manipulative Therapies; Measurement; Measures; Medical Imaging; Methods; Modeling; Motion; Movement; Multi-Institutional Clinical Trial; Musculoskeletal Diseases; Outcome; Patients; Positioning Attribute; Principal Investigator; Program Research Project Grants; Public Domains; Research Design; Research Institute; Research Personnel; Resources; Rotation; Sample Size; Specimen; Spinal; Spinal Canal; Spinal Manipulation; Structure; System; Techniques; Technology; Therapeutic Studies; Translating; United States National Institutes of Health; Vertebral column; analytical method; analytical tool; base; clinical research site; economic impact; in vivo; kinematics; ligamentum flavum; neurophysiology; novel; programs; relating to nervous system; socioeconomics; soft tissue; three-dimensional modeling; tool; user friendly software; validation studies; web site

DESCRIPTION (provided by applicant): The overall goals of the proposed project are to translate analytical techniques developed in the field of basic science spine biomechanics to clinical studies for better understanding of the effects of spinal manipulative therapy on low back pain The specific aims of the proposed project are: (1a) To develop an analytical tool for facet kinematics analysis using 3D CT/MRI models and to validate it with cadaveric specimens, (1b) To validate an analytical tool to measure facet gap space using cadaveric specimen-specific 3D CT/MRI models, (2) To develop a novel analytical tool to measure 3D dimensions of the neural foramen and canal and validate the accuracy of these measurements using human cadaver specimens, and (3) To integrate these new and other existing standalone analytical tools into one user-friendly software package, to be made freely available on the web to investigators of large, multi-site clinical imaging studies on spinal manipulative therapies and the research community overall. New analytical tools for facet kinematics using 3D CT/MRI models and facet-based coordinate systems will be developed. A new method for 3D foramen and spinal canal analysis will be developed using a CT/MR combined 3D model. State-of-the-art technologies, which have been developed for spine biomechanics, will also be adapted for clinical studies on spinal manipulation. The analyses will include: 3D spinal alignment, 3D kinematics of the spinal motion segment during flexion, extension, lateral bending and axial rotation. These analyses will be helpful to understand the relationship between spinal structure and function and changes in spinal structure and movement before and after spinal manipulation. The new techniques to be developed in the proposed project will be validated using cadaveric specimens, and data on the accuracy of individual techniques will be provided for rigorous studies on spinal manipulation. The baseline information will be used for power analyses to assess sample size for future study designs. The analytical methods to be developed and adapted for the studies on effects of spinal manipulation will be integrated in one software package so that even the investigators who are not familiar with mathematical analyses can use these analytical methods. The software package will be released to the public domain through a dedicated website. The outcomes from the proposed study are expected to be equally effective for evaluating other forms of complementary and alternative medicine (CAM) for other musculoskeletal disorders.

描述（由申请人提供）：拟议项目的总体目标是将基础科学脊柱生物力学领域开发的分析技术转化为临床研究，以更好地理解脊柱操纵治疗对下背部的影响 疼痛拟议项目的具体目的是：（1A）使用3D CT/MRI模型开发分析工具，以使用3D CT/MRI模型分析，并使用尸体标本（1B）对其进行验证，以验证一种分析工具来验证一种分析工具，以测量使用尸体标本的工具，以测量3D CT/MRI模型，以测量3D CT/MRI模型（2），以测量3D CT/MRI模型，以实现3D CT/MRI模型（2）。运河和使用人尸体标本验证这些测量值的准确性，（3）将这些新的和其他现有的独立分析工具集成到一个用户友好的软件包中，可以在网络上免费提供，向大型多站点临床成像研究的研究人员提供有关脊柱操纵疗法的大型多站点临床成像研究。将开发使用3D CT/MRI模型和基于Facet的坐标系的Facet运动学的新分析工具。将使用CT/MR组合3D模型开发用于3D孔和脊柱分析的新方法。为脊柱生物力学开发的最先进的技术也将适用于脊柱操纵的临床研究。分析将包括：3D脊柱比对，屈曲，延伸，侧向弯曲和轴向旋转过程中脊柱运动段的3D运动学。这些分析将有助于了解脊柱结构与功能之间的关系以及脊柱操纵前后的脊柱结构和运动的变化。将在拟议项目中开发的新技术将使用尸体标本进行验证，并将为脊柱操纵的严格研究提供有关单个技术准确性的数据。基线信息将用于电源分析，以评估未来研究设计的样本量。要开发和调整用于脊柱操作影响的研究的分析方法将集成到一个软件包中，以便即使是不熟悉数学分析的研究者，也可以使用这些分析方法。该软件包将通过专用网站发布到公共领域。预计拟议研究的结果对于评估其他肌肉骨骼疾病的其他形式的互补和替代医学（CAM）同样有效。