Imaging Shared Service

影像共享服务

• 批准号: 10267055
• 负责人: RAO P GULLAPALLI
• 金额: --
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-08 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10267055
• 关键词: Advisory Services; Animals; Baltimore; Bioluminescence; Biomedical Engineering; Biometry; Blood; Blood - brain barrier anatomy; Cancer Center; Cancer Grant Supplements (P30); Cell Nucleus; Cerebrovascular Circulation; Cerebrum; Clinical; Clinical Oncology; Clinical Research; Clinical Trials; Comprehensive Cancer Center; Consult; Consultations; Data Analyses; Data Collection; Development; Discipline of Nuclear Medicine; Doctor of Philosophy; Drug Delivery Systems; Electron Microscopy; Electrons; Equipment; Experimental Designs; Faculty; Flow Cytometry; Fluorescence; Focused Ultrasound; Functional Imaging; Funding; Genomics; Grant; Health Services Accessibility; Human; Image; Image Analysis; Imaging technology; Immunoelectron Microscopy; Institutes; Institution; Intellectual Property; Interdisciplinary Study; Interventional Ultrasonography; Investigational Therapies; Journals; Knowledge; Laboratories; Liquid substance; Magnetic Resonance Imaging; Malignant Neoplasms; Maryland; Medicine; Mission; Molecular Biology; Nature; New England; Nuclear; Oncology; PET/CT scan; Pathology; Pathway interactions; Peer Review; Population Sciences; Positron-Emission Tomography; Publications; Publishing; Radiology Specialty; Reagent; Research; Research Design; Research Personnel; Resources; Sampling; Scanning Electron Microscopy; Services; Strategic Planning; Structure; Students; Technology; Therapeutic; Tissues; Training; Translating; Translational Research; Universities; Work; acronyms; anticancer research; biobank; biomarker discovery; cellular imaging; clinical investigation; clinical practice; clinical translation; college; confocal imaging; design; experimental study; hormone related cancer; human imaging; image guided; image guided intervention; imaging biomarker; imaging modality; instrument; live cell imaging; medical schools; member; metabolic abnormality assessment; microPET; multidisciplinary; neoplasm immunotherapy; neurosurgery; novel; novel imaging technology; pre-clinical; programs; quantitative imaging; structural biology; success; tool; translational pipeline; transmission process; tumor immunology; whole animal imaging

18.0 Abstract: Imaging Shared Service The Imaging Shared Service (ISS) provides UMGCCC members with a wide array of state-of-the-art imaging services, including structural and functional imaging of cells and imaging of whole animals and humans. ISS assists with experimental design, data analysis, data interpretation, and training to leverage advanced imaging services, accelerate discovery, and develop a robust translational pipeline. ISS resources include state-of-the- art confocal imaging for live cells, fixed tissues, ex vivo samples, and whole animals. ISS electron microscopy service provides transmission electron and scanning electron microscopy (conventional and cryo-samples), and immuno-electron microscopy to meet the needs of UMGCCC investigators. Whole-animal imaging is facilitated by a vast array of instruments, including whole-animal bioluminescence and fluorescence, micro-PET/CT, small- animal MRI for preclinical work, high-field MRI, combined PET/MRI, and CT services to meet the needs of investigators. ISS also provides unique technologies, such as dynamic nuclear hyperpolarization using C-13 and other nuclei, to study metabolic flux in cancer and MR-guided focused ultrasound for interventions that permit drug delivery across the blood–brain barrier. ISS offers an important platform for clinical translation that facilitates clinical trials. Given the multidisciplinary nature of ISS, its leaders and members interact extensively with other shared services and with investigators in all UMGCCC programs. ISS also provides educational opportunities and onsite training to facilitate the design, execution, and analysis of a wide variety of experiments. Staff members of ISS, some of whom are supported by the P30 grant, are experts who help users to define and refine study designs, assess research needs, and provide guidance. ISS advisory sessions often include consults from members of the Biostatistics Shared Service. ISS is committed to providing value-added state-of-the-art services to educate faculty, staff, fellows, and students and to offering advanced imaging technology to UMGCCC investigators. ISS provides streamlined access to services that prioritizes UMGCCC members with peer- reviewed funding. An internal Faculty Oversight Committee, consisting of ISS users, provides advice on core management of ISS and helps to develop strategic planning for new ISS equipment. ISS has very high utilization. In 2019, ISS supported studies by 88 investigators, 58 (65.9%) of whom were affiliated with UMGCCC. ISS users represent all UMGCCC research programs. In 2019, ISS supported $32.8 million of total funding. $17 million this funding was cancer-related and peer reviewed. ISS supported 239 cancer-related publications from 2015 to 2019 including those published in such high-impact journals as Radiology, Journal of Cerebral Blood.

18.0 摘要：影像共享服务 成像共享服务 (ISS) 为 UMGCCC 成员提供各种最先进的成像 服务，包括细胞的结构和功能成像以及整个动物和人类的成像。 协助实验设计、数据分析、数据解释和培训以利用先进的成像 服务、加速发现并开发强大的国际空间站资源（包括最先进的资源）。 适用于活细胞、固定组织、离体样品和整个动物的艺术共聚焦成像。 服务提供透射电子显微镜和扫描电子显微镜（传统样品和冷冻样品），以及 免疫电子显微镜可以满足 UMGCCC 研究人员的需求。 通过大量仪器，包括整个动物生物发光和荧光、微型 PET/CT、小型 用于临床前工作的动物 MRI、高场 MRI、组合 PET/MRI 和 CT 服务，以满足以下需求 国际空间站还提供独特的技术，例如使用 C-13 的动态核超极化和 其他细胞核，研究癌症中的代谢流和 MR 引导的聚焦超声干预措施，以实现允许的干预措施 ISS 为临床转化提供了一个重要的平台，有助于促进药物跨血脑屏障的传递。 鉴于 ISS 的多学科性质，其领导者和成员主要与其他人互动。 与所有 UMGCCC 项目的研究人员共享服务还提供教育机会。 以及现场培训，以促进各种实验的设计、执行和分析。 ISS 的成员是帮助用户定义和完善的专家，其中一些成员得到了 P30 赠款的支持 ISS 咨询会议通常包括研究设计、评估研究需求和提供指导。 ISS 生物统计共享服务的成员致力于提供最先进的增值服务。 教育教职员工、研究员和学生，并向 UMGCCC 提供先进的成像技术 ISS 提供简化的服务访问，优先考虑 UMGCCC 成员和同行。 由 ISS 用户组成的内部教员监督委员会提供有关核心的建议。 管理国际空间站并帮助制定新国际空间站设备的战略规划，利用率非常高。 2019 年，ISS 支持 88 名研究人员的研究，其中 58 名（65.9%）隶属于 ISS。 用户代表了 UMGCCC 的所有研究项目，2019 年，ISS 资助了 17 美元的 3280 万美元。 这笔资金与癌症相关，并经过同行评审，资助了 239 篇与癌症相关的出版物。 2015年至2019年，包括在Radiology、Journal of Cerebral Blood等高影响力期刊上发表的文章。