Vanderbilt Integrated Center of Excellence in Maternal and Pediatric Precision Therapeutics (VICE-MPRINT)

范德比尔特母婴精准治疗卓越综合中心 (VICE-MPRINT)

• 批准号: 10309015
• 负责人: PRINCE Joseph KANNANKERIL
• 金额: $ 125万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10309015
• 关键词: Academic Medical Centers; Address; Adoption; Affect; Algorithms; Area; Artificial Intelligence; Attitude; Bioinformatics; Caring; Child; Childhood; Clinical; Clinical Research; Collaborations; Collection; Communities; Data; Data Linkages; Data Science; Data Set; Development; Devices; Disabled Persons; Discipline of obstetrics; Disease; Dose; Electronic Health Record; Ensure; Environment; Fostering; Foundations; Future; Generations; Genes; Genomics; Goals; Grant; Health; Healthcare; Individual; Infant; Infrastructure; International; Knowledge; Label; Lactation; Leadership; Logistics; Machine Learning; Methodology; Modeling; Mothers; National Institute of Child Health and Human Development; Nature; Neonatal Abstinence Syndrome; Opioid; Outcome; Pediatrics; Persons; Pharmaceutical Preparations; Pharmacogenetics; Pharmacogenomics; Pharmacology Study; Phenotype; Physicians; Population; Positioning Attribute; Postpartum Period; Postpartum Women; Precision therapeutics; Pregnancy; Pregnant Women; Research; Research Personnel; Research Project Grants; Research Training; Resources; Sampling; Scientist; Strategic Planning; Supervision; Testing; Therapeutic; Therapeutic Human Experimentation; Time; Training; Training Activity; Training Support; Translational Research; Translations; United States National Institutes of Health; Variant; Woman; Work; base; biomedical informatics; clinical care; clinically actionable; cohort; data sharing; disability; disparity reduction; education resources; experience; healthy pregnancy; human disease; implementation science; improved; innovation; interdisciplinary approach; investigator training; knowledge base; large datasets; multidisciplinary; novel; opioid exposure; opioid use disorder; precision medicine; pregnant; prescription opioid; programs; response; support tools; therapeutically effective; tool; training opportunity

PROJECT SUMMARY / ABSTRACT - OVERALL There is a rapidly expanding knowledge base enabling precision therapeutics for a number of human diseases, but there are significant unmet needs in evidence generation to support translation to the treatment of children and pregnant/post-partum women. The recent widespread adoption of electronic health records (EHRs) and the linkage of these data to other large datasets represents an unprecedented opportunity for clinical research and discovery. The goals of this Center of Excellence in Maternal and Pediatric Precision Therapeutics are: to address key knowledge gaps and perform clinical research in pharmacogenomics and neonatal opioid withdrawal syndrome; to leverage data science methodologies and develop novel tools that support maternal and pediatric precision therapeutics research; and to enhance training for maternal and pediatric precision therapeutics at the local, regional, and national levels. We bring to this effort a unique collection of investigators, institutional support, tools, and resources that enable a paradigm-shift from current norms of slow, incremental progress. Project 1 will: use a community engaged approach to illuminate knowledge of, attitudes about, and priorities for pharmacogenomics; validate pharmacogenomic associations for maternal and pediatric populations using the innovative and generalizable strategy of EHR phenotyping; and identify and quantify variants with unknown functional consequence in diverse individuals to inform future research efforts and reduce disparities. Project 2 will: develop and validate EHR-based algorithms to identify a cohort of opioid- exposed infants and their mothers (dyads) and create a novel linkage of these data to state-wide data; test the hypothesis that use of medications for opioid use disorder is associated with improved early outcomes; and test the hypothesis that opioid use disorder treatment is associated with improvements in the novel longitudinal outcome of dyadic stability. These projects are led by multidisciplinary teams that include Investigators in Pediatrics and Obstetrics, and who are nationally recognized leaders in their respective fields. Both Projects will be supported by a Scientific Core – the Phenotyping Support Core - which enhances each project with expert phenotyping, machine learning/artificial intelligence, and experience in generalizing and disseminating phenotyping approaches. An Administrative Core will provide logistical support for the Center, supervise training opportunities, and ensure scientific interchange within the CET and with the MPRINT Hub. This work will contribute to innovative approaches to precision therapeutics for mothers and children and will develop the educational infrastructure to support the training of physician-scientists to support further advances well into the future.

项目摘要 /摘要 - 总体 有一个迅速扩大的知识库，可以为多种人类疾病提供精确疗法， 但是，证据生成有很大的未满足需求，以支持翻译为儿童的治疗 和孕妇/产后妇女。最近采用电子健康记录（EHRS）和 这些数据与其他大型数据集的联系代表了临床研究的前所未有的机会 和发现。这个孕产妇和小儿精确治疗中心卓越中心的目标是： 解决关键知识差距并进行药物基因组学和新生儿阿片类药物的临床研究 戒断综合征；利用数据科学方法并开发支持母亲的新颖工具 和小儿精确治疗研究；并增强孕产妇和小儿精度的培训 地方，地区和国家一级的治疗疗法。我们为这项努力带来了独特的集合 调查人员，机构支持，工具和资源，使能够从当前规范 缓慢，增量进度。项目1将：使用社区参与的方法来阐明知识， 关于药物基因组学的态度和优先事项；验证母亲的药物基因组相关 使用EHR表型的创新且可推广的策略，以及儿科种群；并确定和 量化潜水员的功能后果未知的变体，以告知未来的研究工作 并减少分布。项目2将：开发和验证基于EHR的算法，以识别一系列opioid- 暴露于婴儿及其母亲（二元组），并将这些数据与全州数据建立了新的联系；测试 假设将药物用于阿片类药物使用障碍与改善早期结局有关。和 检验阿片类药物使用障碍治疗与新颖的改善有关的假设 二元稳定性的纵向结果。这些项目由多学科团队领导，包括 儿科和妇产科研究人员，他们是各自领域的全国认可领导人。 这两个项目都将得到科学核心的支持 - 表型支持核心 - 可以增强每个项目 通过专家表型，机器学习/人工智能以及概括和经验的项目 传播表型方法。行政核心将为中心提供后勤支持， 监督培训机会，并确保CET内和MPRINT中心内的科学交换。 这项工作将有助于母亲和儿童的精确治疗的创新方法，并将 开发教育基础设施，以支持对身体科学家的培训，以支持进一步的进步 到未来。