The Northwestern University Cancer Health Equity Research SPORE (NU-CHERS)

西北大学癌症健康公平研究 SPORE (NU-CHERS)

基本信息

批准号：
10265425
负责人：
MELISSA A. SIMON
金额：
$ 102.31万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-17 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10265425
关键词：
Accounting Award Bioinformatics Biological Biological Markers Biometry Blood Cancer Research Project Chicago Cities Clinical Clinical Investigator Clinical Research Clinical Trials Collection Communication Communities Complement Comprehensive Cancer Center County DNA DNA Methylation Development Discipline of obstetrics Disease Progression Early Diagnosis Endometrial Carcinoma Endometrial Neoplasms Epigenetic Process Evaluation Event Expression Profiling Fostering Foundations Funding Future Galanin Genes Genomics Goals Gynecologic Gynecologic Oncology Gynecology Hospitals In Vitro Incidence Individual Infrastructure Intervention Lead Leadership Link Location Malignant Female Reproductive System Neoplasm Malignant Neoplasms Malignant neoplasm of ovary Measures Minority Minority Groups Minority Recruitment Modeling Molecular Molecular and Cellular Biology Morbidity - disease rate Organoids Outcome Participant Pathology Pathway interactions Pattern Pilot Projects Platinum Prevention Process Public Hospitals Research Research Personnel Research Project Grants Resistance Resources Science Seeds Serous Solid Tissues Translational Research United States United States National Institutes of Health Universities Vision Woman Work anticancer research base biobank black women cancer health disparity cancer therapy cancer type career development comparative cooking design ethnic minority population exome sequencing experience health disparity health equity improved in vivo infrastructure development innovation insight lens methylome methylomics mortality mutational status novel novel marker outreach patient derived xenograft model precision medicine programs racial and ethnic racial difference racial disparity repository response transcriptome sequencing translational cancer research translational pipeline translational research program translational scientist treatment response tumor

项目摘要

ABSTRACT Centered in Chicago, one of the most diverse yet segregated cities with some of the most striking health disparities in the US, this P20 feasibility and planning proposal to develop the Northwestern University Cancer Health Equity Research SPORE (NU-CHERS) will generate scientific findings and establish sustainable, collaborative, academic and community infrastructure that will serve as the foundation for a comprehensive translational cancer research program focused on gynecologic cancer health disparities. In this proposal, we set our initial translational research focus on endometrial and ovarian cancer disparities as experienced by Black women. This NU-CHERS P20 program leverages outstanding translational research capacity at Northwestern University and its NCI-designated Robert H. Lurie Comprehensive Cancer Center. Research Project 1 investigates racial disparities in endometrial cancer through tumor genomics. Findings will generate critical information that not only deepens our understanding of the biological racial differences in endometrial tumors but can be used as a predictive measure for racial differences in response to treatments. Research Project 2 focuses on racial differences in DNA methylation events in ovarian cancer which may impact response to platinum-based ovarian cancer treatment and explain the striking disparity in survival experienced by Black women. The study will define the methylomes of high-grade serous ovarian cancer in Black and White women as well as develop high-grade serous ovarian cancer-derived patient derived xenografts (PDX) and organoids from which response of these models to platinum will be assessed in vitro and in vivo. Findings will define pathways and genes regulated epigenetically, which could account for disparity in clinical outcomes and may become relevant targets for intervention. To support these projects and build a solid infrastructure for a future funded gynecologic cancer health disparities P50 SPORE, we propose two Cores. The Administrative Core (AC) is the focal point for scientific, fiscal and administrative oversight and integration. The Gynecologic Biospecimen Pathology Core (GBPC) will maintain tissue/blood repositories for current and future NU-CHERS projects, in partnership with the John H. Stroger, Jr. Hospital of Cook County to enhance the availability of minority gynecologic biospecimens available to NU-CHERS researchers. In addition, we propose a Developmental Research Program (DRP) to support NU-CHERS infrastructure development goals and pipeline of translational research excellence. The NU-CHERS P20 team is comprised of basic, translational, and clinical investigators with synergistic strengths poised to forge a lasting translational research program focused on understanding and reducing gynecologic cancer disparities.

抽象的以芝加哥为中心，这是最多元化但最隔离的城市之一，拥有一些最引人注目的健康状况美国的差异，本 P20 开发西北大学癌症中心的可行性和规划建议健康公平研究 SPORE (NU-CHERS) 将产生科学发现并建立可持续的、协作、学术和社区基础设施，将作为全面的基础转化癌症研究计划专注于妇科癌症健康差异。在这个提案中，我们设定我们最初的转化研究重点是黑人所经历的子宫内膜癌和卵巢癌的差异女性。该 NU-CHERS P20 项目利用了西北大学出色的转化研究能力大学及其 NCI 指定的 Robert H. Lurie 综合癌症中心。研究项目1 通过肿瘤基因组学研究子宫内膜癌的种族差异。调查结果将产生关键这些信息不仅加深了我们对子宫内膜肿瘤的生物种族差异的理解但可以用作对治疗反应的种族差异的预测指标。研究项目2 重点关注卵巢癌 DNA 甲基化事件的种族差异，这可能会影响对卵巢癌的反应基于铂的卵巢癌治疗并解释黑人经历的生存率的显着差异女性。该研究将定义黑人和白人女性高级别浆液性卵巢癌的甲基化组以及开发高级别浆液性卵巢癌患者来源的异种移植物（PDX）和类器官将根据这些模型对铂的反应进行体外和体内评估。研究结果将定义表观遗传调控的途径和基因，这可以解释临床结果的差异，并可能成为干预的相关目标。支持这些项目并为未来建立坚实的基础设施资助妇科癌症健康差异 P50 SPORE，我们提出两个核心。行政核心 (AC) 是科学、财政和行政监督与整合的焦点。妇科生物样本病理学核心 (GBPC) 将为当前和未来的 NU-CHERS 项目维护组织/血液储存库，与库克县小约翰·H·斯特罗格医院 (John H. Stroger, Jr. Hospital) 合作，提高少数族裔患者的就诊率 NU-CHERS 研究人员可以获得妇科生物样本。此外，我们还提出了一项发展计划支持 NU-CHERS 基础设施发展目标和转化管道的研究计划 (DRP) 卓越的研究。 NU-CHERS P20 团队由基础、转化和临床研究人员组成凭借协同优势，准备打造持久的转化研究计划，重点关注理解和减少妇科癌症的差异。