Developmental Research Program

发展研究计划

基本信息

批准号：
10265430
负责人：
MELISSA A. SIMON
金额：
$ 15.5万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-17 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10265430
关键词：
Address Area Award Basic Science Biological Clinical Clinical Research Clinical Sciences Collaborations Communities Complex Comprehensive Cancer Center Consult Detection Development Diagnosis Ensure Evaluation Extramural Activities Extramural Funding Mechanisms Faculty Fostering Funding Funding Mechanisms Future Goals Grant Gynecologic Incubators Infrastructure Lead Leadership Link Malignant Female Reproductive System Neoplasm Malignant Neoplasms Melissa Mentorship Methods Modernization Molecular Pathology Pathway interactions Phase Pilot Projects Population Principal Investigator Process Program Research Project Grants Research Research Infrastructure Research Personnel Research Project Grants Resource Sharing Role Schools Science Scientist Seeds Specialized Center Stream Thinking Training Training Programs Translational Research Triage Underrepresented Populations Universities Work base cancer health disparity career collaborative environment community based participatory research community clinic design evaluation/testing faculty research falls health equity high reward high risk improved innovation interdisciplinary collaboration member novel programs success translational approach translational research program translational study

项目摘要

ABSTRACT The NU-CHERS Developmental Research Program (DRP) will serve as the incubator for novel, cutting edge, and competitive translational research of gynecologic cancer disparities. Centered on the theme of Contemporary Translational Approaches to Advancing Health Equity in the Detection, Diagnoses, and Treatment of Gynecologic Cancers, the DRP will identify and fund research pilot projects that utilize innovative clinical and translational research concepts and approaches that fall under DRP’s theme. These research projects will be nurtured by nearly all facets of the grant program, will be supported by ongoing career enhancement programming under the DRP, and will be well poised to seek larger-scale extramural funding or be submitted as a full research project under a P50 SPORE focused on gynecologic cancer disparities. The DRP Co-Directors will work with all areas of the overall grant program, including interacting with the Gynecologic Biospecimen Pathology and Administrative Cores for technical consult and biospecimen access and triage for all potential applicants and awardees; the Leadership Council, Internal Advisory Board, and Community Advisory Board for the review and funding of new projects; and the Leadership Council, Internal Advisory Board, and External Advisory Board for the ongoing evaluation of active funded DRP pilot projects. DRP Specific Aim 1: Through program-wide coordination, build research capacity by establishing the infrastructure, processes, and direction for a SPORE pilot funding mechanism to foster high-impact innovation in clinical and basic science research focused on gynecologic cancer disparities. A central focus of DRP award recipients will be the ability to conduct novel translational research that is high-risk high-payoff to this and future SPORE grants. DRP Specific Aim 2: Establish and support a career enhancement pipeline for early-stage and established investigators to enhance or refocus their career on translational research with a gynecologic cancer disparities focus. We will leverage and foster interdisciplinary and diverse collaborations between internal and external SPORE faculty, research project recipients, community clinic leadership, and community members. DRP Specific Aim 3: Track and evaluate the success of the DRP research projects to ensure further advancement in a full health equity P50 SPORE and other extramural funding mechanisms. We will utilize established and tested evaluation processes and methods to ensure all project teams are optimized for success in future research endeavors, with the ultimate goal of setting the stage for valuable contributions in molecular approaches to tackling gynecologic cancer disparities under a P50 SPORE.

抽象的 NU-CHERS 发展研究计划 (DRP) 将作为新颖、前沿、以及以妇科癌症差异为中心的竞争性转化研究。促进检测、诊断和治疗方面健康公平的当代转化方法妇科癌症方面，DRP 将确定并资助利用创新临床和技术的研究试点项目这些研究项目将属于 DRP 主题的转化研究概念和方法。受到资助计划几乎所有方面的培育，并将得到持续职业提升的支持 DRP 下的规划，并将准备好寻求更大规模的外部资金或作为 P50 SPORE 下的一个完整研究项目，重点关注妇科癌症差异。将与整个资助计划的所有领域合作，包括与妇科生物样本互动病理学和管理核心，用于技术咨询和生物样本获取以及所有潜在潜力的分类申请人和获奖者；领导委员会、内部顾问委员会和社区顾问委员会新项目的审查和资助；以及领导委员会、内部顾问委员会和外部顾问委员会持续评估积极资助的 DRP 试点项目的咨询委员会具体目标 1：通过。整个计划的协调，通过建立基础设施、流程和方向来建设研究能力 SPORE 试点资助机制，以促进临床和基础科学研究的高影响力创新 DRP 获奖者的核心关注点是开展妇科癌症的能力。新颖的转化研究对于本次和未来的 SPORE 资助具有高风险和高回报：为早期和成熟的研究人员建立和支持职业提升渠道，以提高或者将他们的职业生涯重新集中在以妇科癌症差异为重点的转化研究上。促进内部和外部 SPORE 教师、研究之间的跨学科和多样化合作项目接受者、社区诊所领导和社区成员。DRP 具体目标 3：跟踪和记录。评估 DRP 研究项目的成功，以确保进一步推进全面健康公平 P50 我们将利用既定且经过测试的评估流程。和方法，以确保所有项目团队都得到优化，以便在未来的研究工作中取得成功，并最终实现目标是为解决妇科癌症的分子方法的宝贵贡献奠定基础 P50 SPORE 下的差异。