Case GI SPORE

案例 GI 孢子

基本信息

批准号：
8711319
负责人：
SANFORD D. MARKOWITZ
金额：
$ 216.2万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-14 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8711319
关键词：
Aberrant DNA Methylation Accounting Adenocarcinoma Adult Alleles American Archives Attention Barrett Esophagus Barrett&apos s Adenocarcinoma Basic Science Biological Biological Markers Cancer Center Cancer Etiology Cancer Gene Mutation Cessation of life Chemoprevention Clinical Clinical Investigator Colon Carcinoma Colonic Adenoma Colonic Neoplasms Colorectal Cancer Comprehensive Cancer Center DNA Detection Development Disease Disseminated Malignant Neoplasm Early Diagnosis Early treatment Ensure Esophageal Adenocarcinoma Esophagus Ethnic Origin Evaluation Experimental Pathology Faculty Family Feces Formalin Fostering Gender Gene Mutation Genes Genetic Genetic Programming Genetic Screening Genome Genomics Incidence Individual Joints Lesion Malignant Neoplasms Malignant neoplasm of esophagus Malignant neoplasm of gastrointestinal tract Methods Modality Molecular Molecular Profiling Morbidity - disease rate Mutation New Agents Nonmetastatic Outcome Pathway interactions Patients Persons Play Premalignant Prevention Process Recurrence Research Research Infrastructure Research Personnel Research Project Grants Resources Risk Assessment Risk Reduction Sampling Studies Series Services Specialized Program of Research Excellence Staging Statistical Methods Survival Rate Susceptibility Gene Technology Testing Therapeutic Tissue Sample Translational Research United States base cancer chemoprevention cancer genetics cancer genome cancer therapy career development disorder control drug discovery gastrointestinal high throughput screening kindred mortality named group neoplastic next generation next generation sequencing novel novel strategies outcome forecast prognostic programs research and development response screening tumor

项目摘要

This Case Gl SPORE proposal provides for a cutting edge Specialized Program of Research Excellence in gastrointestinal malignancies with emphasis on colorectal cancers and with additional attention to adenocarcinoma of the esophagus. This comprehensive program builds on the resources of the Case Comprehensive Cancer Center to propose 4 translational Research Projects to bring new molecular advances to patients with Gl Cancers. A series of 4 core resources support these research projects and also establish a strong programmatic infrastructure for translational research in Gl cancers. We further have developed a comprehensive infrastructure for identifying new Developmental Research Projects from basic science and clinical investigators from across the Case Cancer Center. Moreover, drawing on our strong track record of developing new faculty who emphasize translational research in Gl cancers, we propose a targeted Career Development Program to further enhance the translational research cadre of SPORE faculty. The 4 SPORE translational research projects constitute novel and cutting edge approaches to Gl cancers and include studies of: the predictive, prognostic, and therapeutic applications of the new 15-PGDH colon cancer suppressor pathway (Project 1, Drs. Markowitz and Willson); the noninvasive early detection of advanced colon adenomas through stool DNA testing for methylated DNA (Project 2, Drs. Cooper and Li); the comprehensive evaluation of colon cancer gene mutations as predictors of clinical outcome, via use of high throughput Next Generation genomic sequencing (Project 3, Drs. Willis and Wang); and the identification of esophageal adenocarcinoma susceptibility genes (Project 4, Drs. Chak and Elston). These projects are advantaged by special population and scientific resources developed by our SPORE faculty for: evaluation of colon cancer biomarkers, for high throughput screening for new drug discovery, for evaluation of colon cancer screening modalities, for Next Generation sequencing from archived formalin fixed tissue samples, and for study of familial Barrett's and adenocarcinomas of the esophagus. The strength of these investigators and the resources at their disposal will ensure this program leads to important advances.

Case GI SPORE 提案提供了胃肠道恶性肿瘤的前沿专业卓越研究计划，重点关注结直肠癌，并额外关注食道腺癌。该综合计划以凯斯综合癌症中心的资源为基础，提出了 4 个转化研究项目，为胃肠道癌症患者带来新的分子进展。一系列 4 个核心资源支持这些研究项目，并为胃肠道癌症的转化研究建立了强大的规划基础设施。我们还开发了一个全面的基础设施，用于从凯斯癌症中心的基础科学和临床研究人员那里识别新的发展研究项目。此外，利用我们在培养强调胃肠癌转化研究的新教师方面的良好记录，我们提出了一项有针对性的职业发展计划，以进一步增强 SPORE 教师的转化研究骨干队伍。 4 个 SPORE 转化研究项目构成了针对 GL 癌症的新颖且前沿的方法，包括以下研究：新 15-PGDH 结肠癌抑制途径的预测、预后和治疗应用（项目 1，Markowitz 和 Willson 博士）；通过粪便 DNA 甲基化 DNA 检测，对晚期结肠腺瘤进行无创早期检测（项目 2，Cooper 博士和 Li 博士）；通过使用高通量下一代基因组测序，对结肠癌基因突变作为临床结果的预测因子进行综合评估（项目 3，Drs. Willis 和 Wang）；以及食管腺癌易感基因的鉴定（项目 4，Chak 和 Elston 博士）。这些项目受益于我们 SPORE 教师开发的特殊人群和科学资源，用于：评估结肠癌生物标志物、用于新药发现的高通量筛选、用于评估结肠癌筛查方式、用于从存档的福尔马林固定组织样本中进行下一代测序，以及家族性巴雷特食管癌和腺癌的研究。这些研究人员的实力和他们所掌握的资源将确保该计划取得重要进展。