Case GI SPORE

案例 GI 孢子

基本信息

批准号：
8332751
负责人：
SANFORD D. MARKOWITZ
金额：
$ 225.03万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-14 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8332751
关键词：
Aberrant DNA Methylation Accounting Adenocarcinoma Adult Alleles American Archives Attention Barrett Esophagus Barrett&apos s Adenocarcinoma Basic Science Biological Biological Markers Cancer Center Cancer Etiology Cancer Gene Mutation Cessation of life Chemoprevention Clinical Clinical Investigator Colon Carcinoma Colonic Adenoma Colonic Neoplasms Colorectal Cancer Comprehensive Cancer Center DNA Detection Development Disease Disseminated Malignant Neoplasm Early Diagnosis Early treatment Ensure Esophageal Adenocarcinoma Esophagus Ethnic Origin Evaluation Experimental Pathology Faculty Family Feces Formalin Fostering Gender Gene Mutation Genes Genetic Genetic Programming Genetic Screening Genome Genomics Incidence Individual Joints Lesion Malignant Neoplasms Malignant neoplasm of esophagus Malignant neoplasm of gastrointestinal tract Methods Modality Molecular Molecular Profiling Morbidity - disease rate Mutation New Agents Nonmetastatic Outcome Pathway interactions Patients Persons Play Premalignant Prevention Process Recurrence Research Research Infrastructure Research Personnel Research Project Grants Resources Risk Assessment Risk Reduction Sampling Studies Screening procedure Series Services Specialized Program of Research Excellence Staging Statistical Methods Survival Rate Susceptibility Gene Technology Testing Therapeutic Tissue Sample Translational Research United States base cancer chemoprevention cancer genetics cancer genome cancer therapy career development disorder control drug discovery gastrointestinal high throughput screening kindred mortality named group neoplastic next generation novel novel strategies outcome forecast prognostic programs research and development response tumor

项目摘要

This Case Gl SPORE proposal provides for a cutting edge Specialized Program of Research Excellence in gastrointestinal malignancies with emphasis on colorectal cancers and with additional attention to adenocarcinoma of the esophagus. This comprehensive program builds on the resources of the Case Comprehensive Cancer Center to propose 4 translational Research Projects to bring new molecular advances to patients with Gl Cancers. A series of 4 core resources support these research projects and also establish a strong programmatic infrastructure for translational research in Gl cancers. We further have developed a comprehensive infrastructure for identifying new Developmental Research Projects from basic science and clinical investigators from across the Case Cancer Center. Moreover, drawing on our strong track record of developing new faculty who emphasize translational research in Gl cancers, we propose a targeted Career Development Program to further enhance the translational research cadre of SPORE faculty. The 4 SPORE translational research projects constitute novel and cutting edge approaches to Gl cancers and include studies of: the predictive, prognostic, and therapeutic applications of the new 15-PGDH colon cancer suppressor pathway (Project 1, Drs. Markowitz and Willson); the noninvasive early detection of advanced colon adenomas through stool DNA testing for methylated DNA (Project 2, Drs. Cooper and Li); the comprehensive evaluation of colon cancer gene mutations as predictors of clinical outcome, via use of high throughput Next Generation genomic sequencing (Project 3, Drs. Willis and Wang); and the identification of esophageal adenocarcinoma susceptibility genes (Project 4, Drs. Chak and Elston). These projects are advantaged by special population and scientific resources developed by our SPORE faculty for: evaluation of colon cancer biomarkers, for high throughput screening for new drug discovery, for evaluation of colon cancer screening modalities, for Next Generation sequencing from archived formalin fixed tissue samples, and for study of familial Barrett's and adenocarcinomas of the esophagus. The strength of these investigators and the resources at their disposal will ensure this program leads to important advances.

该病例GL孢子提案为胃肠道恶性肿瘤的研究卓越研究提供了尖锐的专业计划，重点是结直肠癌，并进一步关注食管腺癌。这个全面的计划以案例综合癌症中心的资源为基础，旨在提出4个转化研究项目，以将新的分子进步带给GL癌症患者。一系列4个核心资源支持这些研究项目，还为GL癌症的转化研究建立了强大的程序基础设施。我们进一步开发了一个全面的基础设施，用于从案例癌症中心的基础科学和临床研究人员那里识别新的发展研究项目。此外，借助我们在GL CANCERS中强调转化研究的新教师的良好往绩，我们提出了一个有针对性的职业发展计划，以进一步增强孢子教师的转化研究干部。 4个孢子翻译研究项目构成了GL癌的新颖和最前沿方法，包括：新的15-PGDH结肠癌抑制途径的预测，预后和治疗应用（项目1，Markowitz和Willson博士）；通过甲基化DNA的粪便DNA测试对晚期结肠腺瘤的无创早期检测（项目2，库珀博士和李）；通过使用高通量下一代基因组测序（项目3，Willis和Wang博士），将结肠癌基因突变作为临床结果的预测的全面评估；以及鉴定食道腺癌易感基因（项目4，Chak和Elston博士）。这些项目受到我们孢子教师开发的特殊人群和科学资源的优势：对结肠癌生物标志物的评估，用于新药发现的高吞吐量筛查，用于评估结肠癌筛查方式，用于从存档的福尔马林固定组织样品中进行下一代测序，以及研究食管的家族性巴雷特和腺癌。这些调查人员的优势及其可用的资源将确保该计划带来重要的进步。