Understanding the Effects of Prostate Cancer on Gay and Bisexual Men

了解前列腺癌对男同性恋和双性恋男性的影响

基本信息

批准号：
8767750
负责人：
B R Simon Rosser
金额：
$ 16.53万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-16 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8767750
关键词：
Acquired Immunodeficiency Syndrome Address Affect Aftercare Age Anal Sex Anti-Retroviral Agents Anus Area Bisexual Cancer Patient Case Study Cells Chronic Disease Complex Couples Data Development Diagnosis Distress Educational Curriculum Erectile dysfunction Functional disorder Funding Gays HIV Health Health Personnel Heterosexuals Individual Intervention Interview Knowledge Left Lesbian Gay Bisexual Transgender Lesbian Gay Bisexual Transgender Intersex Longevity Malignant Neoplasms Malignant neoplasm of prostate Measures Mental Health Minority Outcome Outcomes Research Paper Patients Penetration Persons Physiological Population Prostatectomy Publishing Quality of life Radiation Radical Prostatectomy Recovery Recruitment Activity Rehabilitation Outcome Rehabilitation therapy Reporting Research Research Personnel Risk Role Sampling Science Sex Functioning Sexual Dysfunction Structure Structure of base of prostate Support Groups Surveys Survivors Telephone Testing United States National Institutes of Health Vagina age group base cancer rehabilitation cancer therapy clinical practice cohort condoms evidence base experience health disparity improved instrument male male health men mortality programs response screening sex sexual minority survivorship treatment program

项目摘要

DESCRIPTION (provided by applicant): This application is in response to PA-12-113, Research on the Health of LGBTI Populations, which "encourages researchers to investigate new questions related to LGBTI health" with "high priority placed on research on interventions for [LGBTI] individuals." Survivorship of prostate cancer (PCa) is one such area. Across the lifespan, 1-in-6 gay and bisexual men (GBM) and 1-in-3 male couples will be diagnosed with PCa, making PCa the most common cancer affecting GBM. Yet, almost no research has examined the effects of PCa treatment on GBM's sexual functioning. Sexual dysfunction is the major sequela of PCa treatment, which is deeply distressing in itself, and negatively impacts quality of life post-treatment, resulting in serious negative mental health outcomes. Recent studies indicate sexual outcomes of PCa treatment are significantly worse for GBM than heterosexual men. Physiological differences between anal sex and vaginal sex likely explain, at least in part, this health disparity. Tailored treatment needs to be developed, but is almost entirely unexplored. Missing is research to evaluate the effects of PCa treatment on GBM sexual functioning, research on rehabilitation outcomes, and research to guide development of new treatments tailored to GBM and sex between men. The long-term objective of this research is to develop the first evidence-based PCa rehabilitation curriculum tailored for GBM. As a first step, in this R21 we will conduct the formative research needed to estimate the extent of poor outcomes, confirm need, and assess acceptability and feasibility. There are three specific aims. In Aim 1, we will investigate, in-depth, the experience of PCa treatment on the sexual lives of GBM, their partners, and their relationships. We will conduct a semi-structured, chat or phone interview study of up to 48 GBM PCa patients, partners, and couples, nationally. In Aim 2, we will refine definitions and develop the measures needed to assess sexual dysfunction in GBM. In Aim 3, we will conduct an online quantitative survey of 220 GBM with PCa, which will a) quantify sexual challenges post-treatment, b) assess needs and priorities for rehabilitation, c) develop a new scale to measure sexual functioning in GBM and d) assess the acceptability and feasibility of a new rehabilitation curriculum for GBM with PCa.

描述（由申请人提供）：本申请是为了回应 PA-12-113，《LGBTI 人群健康研究》，其中“鼓励研究人员调查与 LGBTI 健康相关的新问题”，“高度重视对 LGBTI 人群的干预研究” [LGBTI] 个人。”前列腺癌（PCa）的存活率就是这样的一个领域。在整个生命周期中，六分之一的同性恋和双性恋男性 (GBM) 以及三分之一的男性夫妇将被诊断出患有 PCa，这使得 PCa 成为影响 GBM 的最常见癌症。然而，几乎没有研究探讨 PCa 治疗对 GBM 性功能的影响。性功能障碍是前列腺癌治疗的主要后遗症，其本身就令人深感痛苦，并对治疗后的生活质量产生负面影响，导致严重的负面心理健康结果。最近的研究表明，GBM 患者接受 PCa 治疗后的性结果明显比异性恋男性差。肛交和阴道性交之间的生理差异可能至少部分地解释了这种健康差异。需要开发定制的治疗方法，但几乎完全没有探索过。缺少评估 PCa 治疗对 GBM 性功能影响的研究、康复结果的研究以及指导针对 GBM 和男性之间性行为的新疗法开发的研究。这项研究的长期目标是开发第一个针对 GBM 量身定制的循证 PCa 康复课程。作为第一步，在 R21 中，我们将进行所需的形成性研究，以估计不良结果的程度、确认需求并评估可接受性和可行性。具体目标有三个。在目标 1 中，我们将深入调查 PCa 治疗对 GBM 性生活、伴侣及其关系的影响。我们将对全国多达 48 名 GBM PCa 患者、伴侣和夫妇进行半结构化、聊天或电话访谈研究。在目标 2 中，我们将完善定义并制定评估 GBM 性功能障碍所需的措施。在目标 3 中，我们将对 220 个患有 PCa 的 GBM 进行在线定量调查，这将 a) 量化治疗后的性挑战，b) 评估康复的需求和优先事项，c) 开发一个新的量表来衡量 GBM 的性功能，以及d) 评估新的 GBM 与 PCa 康复课程的可接受性和可行性。