Testing Effective Methods to Recruit Sexual and Gender Minority Cancer Patients for Cancer Studies

测试招募性少数癌症患者进行癌症研究的有效方法

基本信息

批准号：
10683296
负责人：
B R Simon Rosser
金额：
$ 58.8万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-12 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10683296
关键词：
Acceleration Accounting Address Advertising Affect Alcohol abuse Area Attitude Belief Bisexual Cancer Burden Cancer Patient Cancer Survivor Caring Clinic Clinic Visits Comparative Study Computerized Medical Record Conceptions Congresses Cybersex Data Data Sources Development Discrimination Ethnic Origin Exclusion Face Female Gays Gender Gender Identity HIV Heterosexuals Intervention Trial Interview Lesbian Gay Bisexual Transgender Literature Malignant Neoplasms Malignant neoplasm of prostate Measures Mental Health Methodology Methods Minority Health Research Outcome Patient Recruitments Patients Performance Persons Population Primary Prevention Professional Organizations Protocols documentation Race Rehabilitation therapy Reporting Research Research Personnel Sampling Sex Orientation Sexual and Gender Minorities Shapes Site Smoking Social support Structure Subgroup Surveys Survivors Telephone Testing Time Underserved Population United States National Institutes of Health Woman Work Workload advanced disease anticancer research cancer care cancer health disparity cancer risk cancer therapy cancer type care delivery cis-female cis-male cisgender comparison group cost design effectiveness testing evidence base experience gender minority gender minority group health disparity informant intersectionality male men minority stress neglect nonbinary novel patient population patient stratification prevent recruit research study satisfaction sex sexual minority sexual minority men sexual minority women social social stigma sociodemographics success theories transgender willingness

项目摘要

Abstract Recently, NCI called for research to effectively study small or rare populations relevant to cancer research. Sexual and gender minorities (SGM) are small populations at disproportionate risk for cancer but who have been under-researched in cancer studies. The principal challenge common across lesbian, gay, bisexual, and transgender populations is to develop effective methods to identify and recruit patients and survivors who are SGM into NCI cancer studies. Two technical advances have transformative potential to advance research on health disparities in SGM cancer patients. First, online recruitment has yielded large SGM samples in other areas of research (e.g., HIV primary prevention), but using online methods to recruit SGM cancer patients has not been rigorously studied. Second, cancer clinics have begun to include sexual orientation and gender identity (SOGI) data in the electronic medical record, but we need to test protocols on how to recruit SGM cancer patients using this data source. This application is based upon our recent success in overcoming challenges to recruit over 400 gay and bisexual prostate cancer patients into an R01 intervention trial of tailored rehabilitation for this population. We will replicate and expand upon these clinic-based and online methods to study how to recruit three small SGM populations – (1) sexual minority cisgender men, (2) sexual minority cisgender women, and (3) transgender and gender non-binary cancer patients - into cancer research studies. We have three specific aims. In Aim 1, we will document, in depth, SGM’s attitudes towards participating in NIH cancer research, identifying the facilitators and barriers that each group reports influences their willingness to participate. We will also investigate any impact poor cancer care and discrimination has on research participation. We will investigate these in cisgender SM men, cisgender SM women and gender minority cancer patients (n=15 per group) and compare experiences within these small populations and between SGM and a cisgender, heterosexual patient comparison group. In Aim 2, we will test the effectiveness, efficiency, cost, and workload in using two clinic SOGI-based strategies and three online strategies to recruit SGM small populations (150 each) compared to recruiting a sample of cisgender, heterosexual cancer patients. We predict size of the small population will negatively correlate with work, cost, and time involved, but positively correlate with yield. In Aim 3, we will conduct an online quantitative survey of willingness to participate in cancer research with 450 SGM cancer patients (150 per group) versus a cisgender heterosexual group (150 men and 150 women). Key measures assess facilitators and barriers to participation in NIH cancer research. To advance measures, we will assess performance of each group on five validated cancer scales to compare cancer care experience, discrimination in treatment, and outcomes. Finally, we will integrate and triangulate findings and assess intersectionality with race/ethnicity. This study will establish what recruitment strategies are effective across SGM populations, and which may be specific to each subgroup.

抽象的最近，NCI呼吁进行研究，以有效研究与癌症研究相关的小或稀有人群。性和性别少数民族（SGM）是癌症风险不成比例的人群在癌症研究中的研究不足。在女同性恋，同性恋，双性恋和跨性别人群是开发有效的方法来识别和招募患者和幸存者 SGM进入NCI癌症研究。两种技术进步具有推进研究的变革潜力 SGM癌症患者的健康差异。首先，在线招聘在其他方面产生了大量SGM样本研究领域（例如HIV初级预防），但使用在线方法招募SGM癌症患者并非严格研究。其次，癌症诊所已经开始包括性取向和性别电子病历中的身份（SOGI）数据，但是我们需要测试如何募集SGM的协议使用此数据来源的癌症患者。该应用程序基于我们最近在克服方面的成功招募400多名男同性恋和双性恋前列腺癌患者的挑战为该人群量身定制的康复。我们将复制并扩展这些基于诊所和在线的研究如何招募三个小型SGM人群的方法 - （1）性少数族裔scisgender，（2）性少数族裔妇女和（3）变性和性别非二进制癌症患者 - 进入癌症研究研究。我们有三个具体的目标。在AIM 1中，我们将深入记录SGM的与会者参加NIH癌症研究，确定每个小组报告的促进者和障碍他们愿意参加。我们还将调查癌症护理不良的任何影响，并歧视对研究参与。我们将在Cisgender SM，Cisgender SM女性和性别中进行调查少数癌症患者（每组n = 15），并比较这些小人群中的经验在SGM和Cisgender，异性恋患者比较组之间。在AIM 2中，我们将测试使用两种基于SOGI的诊所的策略和三种在线的有效性，效率，成本和工作量与招募Cisgender样本相比，招募SGM少数人口的策略（每个150），异性癌患者。我们预测，小人口的规模将与工作，成本，涉及的时间，但与产量正相关。在AIM 3中，我们将对愿意与450名SGM癌症患者（每组150）参加癌症研究异性恋群体（150名男性和150名女性）。关键措施评估促进者和参与障碍在NIH癌症研究中。为了提出措施，我们将评估每个组的绩效，以五个经过验证癌症量表以比较癌症护理经验，治疗中的歧视和结果。最后，我们会的综合和三角发现和评估与种族/种族的交集。这项研究将确定什么招聘策略在SGM人群中有效，并且可能针对每个亚组。