Administrative Core

行政核心

• 批准号: 10259736
• 负责人: BRUCE E. JOHNSON
• 金额: $ 40.31万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-24 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10259736
• 关键词: Accountability; Atlases; Benchmarking; Boston; Cancer Biology; Cells; Clinical; Colon Carcinoma; Colorectal Cancer; Communication; Communities; Cross Presentation; Dana-Farber Cancer Institute; Data Coordinating Center; Ecosystem; Elements; Ensure; Expenditure; General Hospitals; Genomics; Geography; Goals; Histologic; Human; Immunology; Immunotherapy; Lead; Leadership; Logistics; Malignant Neoplasms; Maps; Massachusetts; Monitor; Nature; Oncology; Persons; Reporting; Research; Research Activity; Resistance; Sampling; Series; Structure; System; Technology; base; malignant breast neoplasm; meetings; melanoma; programs; spatial relationship; therapy resistant; tool; tumor

The overarching goal of the Boston Human Tumor Atlas Network Research Center (HTA-RC) is to create three comprehensive atlases of the cellular geography of human melanoma, colorectal cancer, and breast cancer, to understand how changes in the tumor ecosystem lead each to therapeutic resistance. The atlases will map the topography of the number, nature, and spatial relationship of cells and histological structures that distinguish those tumors resistant to targeted and immune-based therapies. The Administrative Core will be responsible for the leadership, governance, and accountability of the Boston HTA-RC. The Core will coordinate and evaluate each component of the Research Center (RC); provide operational oversight of all aspects of the program; and monitor progress toward milestones. In particular, the Core will Provide overall management and coordination of RC activities (Aim 1). It will monitor progress toward the milestone goals, oversee financial expenditures, and provide support for all facets of the Center's activities, through: liaising closely with the Center's leadership and unit leads; project management and fiscal oversight; and on-going guidance from a local steering committee comprising domain experts in relevant fields. The core will also provide logistical support and facilitate communication within and outside the RC (Aim 2), to ensure dynamic interaction between all elements of the Center. A project manager will oversee flow of information, physical samples, and technologies between Units, leveraging both state-of-the-art electronic tracking systems, live and transparent aids, and active interaction through regular leadership meetings, steering committee meetings, an external advisory board, and an annual retreat. The Boston HTA-RC will be deeply embedded in the vibrant clinical and scientific communities at DFCI, Broad, and Massachusetts General Hospital (MGH), Harvard, and Stanford, and the Core will also be responsible for communication with the broader HTA network, the Data Coordinating Center, and the NCI. Finally, the core will evaluate progress toward milestones (Aim 3), based on a series of quantitative milestones we developed. It will assess milestone progress on a regular basis, provide reports to the Leadership Team, and develop proposals for any blocking issues or milestone revisions needed for discussions with NCI Program Officials.

波士顿人类肿瘤图谱网络研究中心 (HTA-RC) 的总体目标是 创建人类黑色素瘤细胞地理学的三张综合图集， 结直肠癌和乳腺癌，了解肿瘤生态系统如何变化 导致各自产生治疗耐药性。地图集将绘制数字、自然、 以及区分肿瘤耐药的细胞和组织学结构的空间关系 靶向和免疫疗法。行政核心将负责 波士顿 HTA-RC 的领导、治理和问责。核心将协调并 评估研究中心（RC）的每个组成部分；提供所有运作监督 计划的各个方面；并监控里程碑的进展。特别是，核心将 提供区域协调活动的全面管理和协调（目标 1）。它将监控 实现里程碑目标的进展，监督财务支出，并为所有人提供支持 通过以下方式了解中心活动的各个方面： 与中心领导层和单位密切联络 线索；项目管理和财务监督；以及当地指导部门的持续指导 由相关领域的领域专家组成的委员会。该核心还将提供后勤保障 支持和促进区域委员会内外的沟通（目标 2），以确保动态 中心所有元素之间的互动。项目经理将监督信息流， 物理样本和单位之间的技术，利用最先进的电子 跟踪系统、实时透明的辅助工具以及通过定期领导进行的积极互动 会议、指导委员会会议、外部顾问委员会和年度务虚会。这 波士顿 HTA-RC 将深深融入充满活力的临床和科学界 DFCI、布罗德医院、马萨诸塞州总医院 (MGH)、哈佛大学、斯坦福大学以及核心医院 还将负责与更广泛的 HTA 网络（数据协调中心）进行通信 中心和 NCI。最后，核心将评估里程碑（目标 3）的进展，基于 我们制定了一系列量化里程碑。它将定期评估里程碑进展 向领导团队提供报告，并针对任何阻碍问题或问题制定建议 与 NCI 计划官员讨论所需的里程碑修订。