Biologic Specimen Bank for Early Lung Cancer Markers in Chinese Tin Miners

中国锡矿工人早期肺癌标志物生物样本库

• 批准号: 8157901
• 负责人: Philip Taylor
• 金额: $ 9.77万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8157901
• 关键词: Chinese People; Malignant neoplasm of lung; Specimen; Tin

OBJECTIVE: The overall goal of this project is to identify strategies to reduce lung cancer incidence and mortality. Specific objectives are to 1) establish a biologic specimen bank and data bank that can be used for the validation and refinement of potential early markers of lung cancer and 2) establish a cohort for the study of environmental (including dietary) and genetic risk factors for lung cancer. BACKGROUND: Lung cancer is the leading cause of cancer death in the U.S. While relative survival rates for localized disease are dramatically better than for nonlocalized disease, most patients are not diagnosed early enough for present therapies to be effective, and early detection by screening with conventional modalities (i.e., chest x-ray and/or sputum cytology) has not been shown to be beneficial. Potential strategies to reduce the incidence and mortality of lung cancer include new methods of early detection, and identification and alteration of etiologic factors. METHODS: Miners in the Yunnan Tin Corporation have an extraordinary rate of lung cancer due to exposure to radon, arsenic, and tobacco. Over 7000 high-risk miners (40+ years old with 10+ years of underground and/or smelting experience)have been the target of an annual lung cancer screening program (CXR and sputum cytology)for the past 20+ years. Between 1992 and 1999 sputum samples were collected and stored annually for future early marker research, and new cases of lung cancer ascertained. Prediagnostic sputum and other biologic samples are stored for analysis for potential early markers (e.g., biochemical, molecular or monoclonal antibody markers) utilizing a nested case-control approach. PROGRESS: Over 450 lung cancer were identified through 1999 in this cohort. Analyses to date have evaluated occupational exposures (arsenic and radon), smoking, and medical conditions; a number of serum antioxidants (carotenoids, selenium, tocopherols); and one potential marker in sputum (Mab 703D4 in the detection of hnRNP). New follow-up has been initiated to update vital and cancer status through 2005.

目的：该项目的总体目标是确定降低肺癌发病率和死亡率的策略。具体目标是1）建立一个生物标本库和数据库，可用于验证和完善肺癌潜在的早期标志物，2）建立研究群体研究（包括饮食）和肺癌遗传危险因素的同类。背景：肺癌是美国癌症死亡的主要原因，而局部疾病的相对存活率显着比非局部疾病更好，大多数患者没有足够及早诊断为目前的疗法以使其有效，并且通过常规方式（即，胸部X射线和/或尖峰细胞学）筛查的早期发现是有益的。降低肺癌发病率和死亡率的潜在策略包括新的早期检测方法以及病因学因素的鉴定和改变。方法：由于暴露于ra，砷和烟草，云南锡公司的矿工患肺癌的率很高。在过去的20多年中，超过7000名高危矿工（40岁以上拥有10年以上的地下和/或冶炼经验）是年度肺癌筛查计划（CXR和痰细胞学）的目标。在1992年至1999年之间，每年收集并存储痰样品，以进行未来的早期标记研究，并确定了肺癌的新病例。使用嵌套的病例对照方法，使用诊断性痰液和其他生物样品进行分析，以分析潜在的早期标记（例如生化，分子或单克隆抗体标记）。进展：整个1999年在该队列中确定了450多个肺癌。迄今为止的分析已经评估了职业暴露（砷和ra），吸烟和医疗状况；许多血清抗氧化剂（类胡萝卜素，硒，生育酚）；以及痰中的一个潜在标记（在HNRNP检测中的mAb 703d4）。已开始新的随访，以更新2005年的生命和癌症状况。