Biologic Specimen Bank for Early Lung Cancer Markers in

早期肺癌标志物生物样本库

• 批准号: 7331229
• 负责人: Philip Taylor
• 金额: --
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7331229
• 关键词: Biologic; Specimen; Bank; Early; Lung

OBJECTIVE: The overall goal of this project is to identify strategies to reduce lung cancer incidence and mortality. Specific objectives are to 1) establish a biologic specimen bank and data bank that can be used for the validation and refinement of potential early markers of lung cancer and 2) establish a cohort for the study of environmental (including dietary) and genetic risk factors for lung cancer. BACKGROUND: Lung cancer is the leading cause of cancer death in the U.S. While relative survival rates for localized disease are dramatically better than for nonlocalized disease, most patients are not diagnosed early enough for present therapies to be effective, and early detection by screening with conventional modalities (i.e., chest x-ray and/or sputum cytology) has not been shown to be beneficial. Potential strategies to reduce the incidence and mortality of lung cancer include new methods of early detection, and identification and alteration of etiologic factors. METHODS: Miners in the Yunnan Tin Corporation have an extraordinary rate of lung cancer due to exposure to radon, arsenic, and tobacco. Over 7000 high-risk miners (40+ years old with 10+ years of underground and/or smelting experience)have been the target of an annual lung cancer screening program (CXR and sputum cytology)for the past 20+ years. Between 1992 and 1999 sputum samples were collected and stored annually for future early marker research, and new cases of lung cancer ascertained. Prediagnostic sputum and other biologic samples are stored for analysis for potential early markers (e.g., biochemical, molecular or monoclonal antibody markers) utilizing a nested case-control approach. PROGRESS: Over 450 lung cancer were identified through 1999 in this cohort. Analyses to date have evaluated occupational exposures (arsenic and radon), smoking, and medical conditions; a number of serum antioxidants (carotenoids, selenium, tocopherols); and one potential marker in sputum (Mab 703D4 in the detection of hnRNP). New follow-up has been initiated to update vital and cancer status through 2005.

目的：该项目的总体目标是确定降低肺癌发病率和死亡率的策略。具体目标是 1) 建立可用于验证和细化肺癌潜在早期标志物的生物样本库和数据库，2) 建立研究肺癌的环境（包括饮食）和遗传风险因素的队列。肺癌。背景：肺癌是美国癌症死亡的主要原因。虽然局部疾病的相对生存率明显优于非局部疾病，但大多数患者诊断不够早，目前的治疗方法无法发挥作用，也无法通过常规筛查进行早期发现。方法（即胸部 X 光检查和/或痰细胞学检查）尚未被证明是有益的。降低肺癌发病率和死亡率的潜在策略包括早期检测、识别和改变病因的新方法。方法：云南锡业公司的矿工由于接触氡、砷和烟草，肺癌发病率极高。过去 20 多年来，超过 7000 名高危矿工（40 岁以上，具有 10 年以上井下和/或冶炼经验）一直是年度肺癌筛查计划（CXR 和痰细胞学检查）的目标。 1992年至1999年间，每年都会收集并储存痰样本，用于未来的早期标记物研究，并确定新的肺癌病例。存储诊断前痰液和其他生物样本，以利用巢式病例对照方法分析潜在的早期标记物（例如生化、分子或单克隆抗体标记物）。进展：截至 1999 年，该队列中已发现超过 450 例肺癌。迄今为止的分析评估了职业暴露（砷和氡）、吸烟和医疗状况；多种血清抗氧化剂（类胡萝卜素、硒、生育酚）；以及痰液中的一种潜在标记物（用于检测 hnRNP 的 Mab 703D4）。新的后续行动已启动，以更新 2005 年的生命和癌症状况。