Cortical encoding of unconscious visual information and its impact on behavior
无意识视觉信息的皮质编码及其对行为的影响
基本信息
- 批准号:10256012
- 负责人:
- 金额:$ 37.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-30 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:Age related macular degenerationAmblyopiaAnimalsAreaAttentionAwarenessBase of the BrainBehaviorBehavioralBrainCellsCodeComplexConsciousDiabetic RetinopathyDiscriminationElectrodesExhibitsExposure toGoalsHumanImageIndividualLeadLearningLifeLinkMacacaMasksNeuronsPerceptionPerformancePopulationPropertyResearchResolutionSensoryStimulusStrokeSubliminal StimulationTechniquesTestingTimeUnconscious StateV1 neuronV4 neuronVisionVisual CortexVisual PerceptionVisual impairmentarea V1area V4basecalmodulin-dependent protein kinase IIeffective therapyexperienceexperimental studyimprovedmillisecondneuronal circuitrynonhuman primatenoveloptogeneticspromoterreceptive fieldrelating to nervous systemresponsespatiotemporalstimulus processingvisual informationvisual stimulus
项目摘要
PROJECT SUMMARY/ABSTRACT
Stimuli presented too briefly to be noticed can nonetheless facilitate the perceptual processing of the same
stimuli many minutes later. Whereas the phenomenon of subliminal priming has been known for decades,
whether and how sensory information is encoded in the brain in the absence of awareness in a way that
influences subsequent sensory processing across neuronal circuits remains a mystery. We will answer these
questions for the first time by examining, at single cell resolution, whether exposure to subliminal stimuli
influences perceptual performance and the coding of information across visual cortical populations. To
accomplish this goal, we will use multiple-electrode recording of single-unit activity in macaque early and mid-
level visual cortical areas (V1 and V4) and behavioral techniques to examine the dynamics and coding in
neuronal populations during and after subliminal exposure, and their impact on perceptual performance. Aim 1
will investigate whether exposure to subliminal stimuli increases subsequent perceptual performance and the
amount of information encoded in population activity. Our hypothesis is that subliminal exposure improves
perceptual discrimination performance when stimuli are subsequently presented above the detectability
threshold, and increases the amount of information extracted from the population response. Aim 2 will examine
the mechanism of the improvement in neuronal and behavioral performance after subliminal exposure. We will
first focus on causal experiments involving optogenetic inactivation which will test whether suppressing
neuronal activity in visual cortex during the presentation of subliminal stimuli reduces the strength of subliminal
priming. Cross-correlation analysis will subsequently test whether improved network and perceptual
performance after subliminal exposure is consistent with a Hebbian mechanism underlying the increase in
functional connectivity specifically for the neurons activated by subthreshold stimuli. Aim 3 will examine the
impact of attention on the relationship between subliminal priming and neuronal and perceptual performance.
We will test the novel hypothesis that spatial attention reduces the efficacy of subliminal priming – exposure to
unattended subliminal stimulation will be associated with a larger improvement in network coding and
perceptual performance compared to exposure to attended information. In contrast, we expect that attention
will increase the strength of supraliminal priming, i.e., exposure to attended subliminal stimulation will be
associated with a larger improvement in network coding and perceptual performance compared to exposure to
unattended information. Taken together, our proposed experiments can potentially advance our understanding
of information coding in visual cortex by testing the limits of sensory experience and its relationship with
perception, which will help develop effective therapies to treat the brain-based aspects of low vision conditions,
such as amblyopia, age-related macular degeneration, diabetic retinopathy, or stroke.
项目概要/摘要
呈现得太短暂而不易被注意到的刺激仍然可以促进对同一刺激的知觉处理。
几分钟后刺激,除了潜意识启动现象几十年前就已为人所知,
在缺乏意识的情况下,感觉信息是否以及如何在大脑中编码
影响随后的神经回路感觉处理仍然是一个谜,我们将回答这些问题。
首次通过在单细胞分辨率下检查是否暴露于阈下刺激来提出问题
影响视觉皮层群体的感知表现和信息编码。
为了实现这一目标,我们将使用多电极记录猕猴早期和中期的单个单元活动
视觉皮层区域(V1 和 V4)和行为技术来检查动态和编码
阈下暴露期间和之后的神经群体及其对知觉表现的影响目标 1。
将调查暴露于阈下刺激是否会增加随后的知觉表现以及
我们的假设是,潜意识暴露会改善人口活动中编码的信息量。
当刺激随后出现在可检测性之上时的知觉辨别表现
阈值,并增加从目标 2 将检查的人群响应中提取的信息量。
我们将探讨潜意识暴露后神经和行为表现改善的机制。
首先关注涉及光遗传学失活的因果实验,该实验将测试是否抑制
阈下刺激呈现期间视觉皮层的神经活动会降低阈下刺激的强度
互相关分析随后将测试网络和感知是否得到改进。
潜意识暴露后的表现与赫布机制一致,后者是
目标 3 将检查阈下刺激激活的神经元的功能连接。
注意力对阈下启动与神经和知觉表现之间关系的影响。
我们将测试一个新的假设,即空间注意力会降低阈下启动的效果——暴露于
无人值守的阈下刺激将与网络编码和网络编码的更大改进相关联。
与接触信息相比,感知表现相反,我们期望注意力。
将增加阈上启动的强度,即暴露于阈下刺激将
与暴露于环境相比,与网络编码和感知性能的更大改善相关
综上所述,我们提出的实验可能会增进我们的理解。
通过测试感官体验的极限及其与视觉皮层的关系来研究视觉皮层的信息编码
感知,这将有助于开发有效的疗法来治疗低视力疾病的大脑方面,
例如弱视、年龄相关性黄斑变性、糖尿病性视网膜病变或中风。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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VALENTIN DRAGOI其他文献
VALENTIN DRAGOI的其他文献
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{{ truncateString('VALENTIN DRAGOI', 18)}}的其他基金
Neural coding of natural stimuli in freely moving macaque
自由移动猕猴自然刺激的神经编码
- 批准号:
10524592 - 财政年份:2022
- 资助金额:
$ 37.2万 - 项目类别:
Cortical encoding of unconscious visual information and its impact on behavior
无意识视觉信息的皮质编码及其对行为的影响
- 批准号:
10653902 - 财政年份:2020
- 资助金额:
$ 37.2万 - 项目类别:
Cortical encoding of unconscious visual information and its impact on behavior
无意识视觉信息的皮质编码及其对行为的影响
- 批准号:
10440471 - 财政年份:2020
- 资助金额:
$ 37.2万 - 项目类别:
The Impact of Sleep on Network Coding and Perceptual Performance
睡眠对网络编码和感知性能的影响
- 批准号:
10543110 - 财政年份:2016
- 资助金额:
$ 37.2万 - 项目类别:
The Impact of Sleep on Network Coding and Perceptual Performance
睡眠对网络编码和感知性能的影响
- 批准号:
10392202 - 财政年份:2016
- 资助金额:
$ 37.2万 - 项目类别:
The Impact of Sleep on Network Coding and Perceptual Performance
睡眠对网络编码和感知性能的影响
- 批准号:
9565710 - 财政年份:2016
- 资助金额:
$ 37.2万 - 项目类别:
Administrative Supplement: Anion channelrhodopsin-based viral tools to manipulate brain networks in behaving animals
行政补充:基于阴离子通道视紫红质的病毒工具可操纵行为动物的大脑网络
- 批准号:
9268890 - 财政年份:2016
- 资助金额:
$ 37.2万 - 项目类别:
Anion channelrhodopsin-based viral tools to manipulate brain networks in behaving animals
基于阴离子通道视紫红质的病毒工具可操纵行为动物的大脑网络
- 批准号:
9321918 - 财政年份:2015
- 资助金额:
$ 37.2万 - 项目类别:
Examining Population Coding Underlying Complex Behavior in Freely Moving Primates
检查自由活动的灵长类动物复杂行为背后的群体编码
- 批准号:
7979898 - 财政年份:2010
- 资助金额:
$ 37.2万 - 项目类别:
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Cortical encoding of unconscious visual information and its impact on behavior
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