New Strategies and Challenges in Lung Proteomics and Metabolomics

肺蛋白质组学和代谢组学的新策略和挑战

基本信息

批准号：
8911120
负责人：
RUSSELL Paul BOWLER
金额：
$ 0.5万
依托单位：
NATIONAL JEWISH HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-01 至 2016-07-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Metabolomics and Proteomics are two rapidly evolving, cutting edge techniques to simultaneously study large numbers of small molecules and proteins. The NHLBI has increasingly supported metabolomics and proteomics research initiatives for heart, lung, and blood diseases; however, there have been no lung specific initiatives. Furthermore, the lung presents unique challenges because of a unique mucus and aqueous epithelial barrier with constant exposure to the external environment as well as a vasculature that filters nearly the entire blood supply. These features create some unmet research challenges for metabolomics and proteomics such as: unique composition and sample preparation of lung epithelial lining fluid, the environmental impact on lung metabolites, a lack o Informatics approaches to shared databases for the lung, and difficulties in Integration of data across genetic and genomic databases. This meeting will address these challenges by bringing together a large diverse group of senior and junior investigators who work on lung proteomics and metabolomics. The meeting will take place in Denver, Colorado at National Jewish Health, an institution that is well known in the pulmonary research community and has a 100+ year history of supporting pulmonary research. The location is easily accessible to many participants though a centrally located airport with non-stop flights to many North American cities. The organizers plan to gain wide degree of support from other relevant institutions such as the American Thoracic Society, Colorado Biological Mass Spectrometry Society, etc. We plan to seek support to publish to findings The overall objectives of this meeting are: 1) Fill a knowledge gap in lung metabolomics and proteomics 2) Stimulate conversations and cross-pollination between pulmonary research scientists, mass spectrometists, and biostatisticians. 3) To initiate a dialogue between clinician-scientists and researchers interested in pulmonary pathobiology. 4) To educate pulmonary scientists about the potential cross-talk between the environment and the lung 5) Provide an international forum for leading clinicians and researchers to exchange ideas relating to lung proteomics and metabolomics. 6) Stimulate new perspectives and further research in pulmonary proteomics and metabolomics in health and disease determine if and how the alteration in the lung proteome or metabolme leads to or alters respiratory disorders 7) To create an environment that will lead to sustained interest among trainees 8) Create standardized operation procedures that can be shared among research groups to improved generalizability of research.

描述：代谢组和蛋白质组学是小分子和蛋白质的两个快速进化。恒定的外部环境和腹部几乎过滤的腹部供应。 ND基因组数据库的数据将通过从事肺部蛋白质组学和代谢组学的大量高级和初级调查员来解决这些挑战。在肺部研究社区中众所周知，拥有100多年的肺部研究历史，尽管有一个不停地飞往许多北美城市的centrat Ed机场，但许多参与者都可以使用该位置。这次会议的其他相关研究所的支持是：1）填补肺代谢组学和蛋白质组学的知识差距2）刺激肺部研究科学家，质谱学家和生物统计学之间的刺激对话和交叉授粉。对肺病病学感兴趣的ST和研究人员健康和疾病中肺蛋白质组学的研究确定LUN G中的变化是否以及如何导致或改变呼吸系统疾病7）在受训者中创造一个环境的兴趣8）创建标准化的操作t可以在研究小组之间共享标准化的操作，以改善可推广性研究。