HIV Infection In Vivo And In Vitro

HIV 体内和体外感染

• 批准号: 8148432
• 负责人: Daniel Cesar Douek
• 金额: $ 31.1万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8148432
• 关键词: HIV Infections; In Vitro; in vivo

HIV is known to primarily replicate in activated CD4+ T cells. In vitro studies have assessed the ability of HIV to replicate in multiple subsets of CD4+ T cells, and have identified several potential sources of T cells that are subject to infection by HIV. However, it remains unclear which CD4+ T cells are most frequently infected in vivo, and the impact of infection of these various subsets. This study seeks to define the subsets of CD4+ T cells that are naturally infected in patients, the anatomical sites of those infected cells and the impact upon HIV- and pathogen-specific immunity and the latent reservoir of HIV.

已知HIV主要在活化的CD4+ T细胞中复制。体外研究已经评估了HIV在CD4+ T细胞的多个子集中复制的能力，并鉴定出了D细胞的多种潜在来源，这些潜在的来源可能会受到HIV感染。但是，尚不清楚哪种CD4+ T细胞最常在体内感染，以及这些各种子集的感染的影响。这项研究旨在定义自然感染的CD4+ T细胞的子集，这些感染细胞的解剖部位以及对HIV和病原体特异性免疫的影响以及HIV的潜在储层。