The Thymus In HIV Infection And Immune Reconstitution

HIV 感染和免疫重建中的胸腺

• 批准号: 6684267
• 负责人: Daniel Cesar Douek
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6684267
• 关键词: AIDS therapy; HIV infections; developmental immunology; enzyme linked immunosorbent assay; flow cytometry; human subject; interleukin 7; organ culture; pathologic process; patient oriented research; polymerase chain reaction; thymus

In HIV-infected patients treated with HAART, there are variable rates of reconstitution of T cell numbers and function. An understanding of the mechanisms underlying the recovery of T cells will be important for the design of future strategies to improve T cell reconstitution. The thymus is the organ responsible for producing new naive T cells with a broad immune repertoire from bone marrow-derived precursors. IL-7 is a cytokine that has direct effects upon the thymus and naive T cells. This study examines the role of the thymus in HIV infection and immune reconstitution, and how IL-7 can affect that role.

在接受HAART治疗的HIV感染患者中，T细胞数量和功能的重建率差异。对T细胞恢复基础机制的理解对于设计未来改善T细胞重建的策略至关重要。胸腺是负责从骨髓衍生的前体中产生新的幼稚T细胞的器官。 IL-7是一种直接影响胸腺和幼稚T细胞的细胞因子。这项研究检查了胸腺在HIV感染和免疫重建中的作用，以及IL-7如何影响该作用。