T Cell Immune Responses To HIV And Other Pathogens

T 细胞对 HIV 和其他病原体的免疫反应

• 批准号: 7184263
• 负责人: Daniel Cesar Douek
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7184263
• 关键词: AIDS vaccines; HIV infections; T cell receptor; cellular immunity; clinical trials; cytotoxic T lymphocyte; enzyme linked immunosorbent assay; flow cytometry; helper T lymphocyte; host organism interaction; human immunodeficiency virus 1; human subject; immune response; immunoregulation; lymphocyte proliferation; microorganism immunology; patient oriented research; polymerase chain reaction; stainings; virus antigen; virus genetics; virus infection mechanism; virus replication

We have yet to fully define the immune responses associated with immunologic control of HIV replication. To develop an effective vaccine, we need to better understand the responses that may be controlling HIV, and why these defenses might fail. This study examines the T cell immune responses to HIV in naturally-infected subjects. It compares these responses with those generated against other viruses and non-viral pathogens in order to determine mechanisms of success or failure of an immune response.

我们尚未完全定义与HIV复制的免疫控制相关的免疫反应。要开发有效的疫苗，我们需要更好地了解可能控制艾滋病毒的反应，以及为什么这些防御能力可能失败。这项研究检查了自然感染受试者中T细胞对HIV的免疫反应。它将这些反应与针对其他病毒和非病毒病原体产生的反应进行了比较，以确定免疫反应成功或失败的机制。