Dictyostelium Community Resource

盘基网柄菌社区资源

• 批准号: 10247062
• 负责人: REX L CHISHOLM
• 金额: $ 81.83万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10247062
• 关键词: Bar Codes; Biological; Biomedical Research; Birds; Caring; Cell physiology; Chemotaxis; Cloning; Collaborations; Collection; Communication; Communities; Data; Data Display; Data Storage and Retrieval; Dictyostelium; Dictyostelium discoideum; Disease; Electronic Mail; Equipment and supply inventories; Eukaryota; Eye; Family; Fostering; Funding; Genbank; Gene Proteins; Genes; Genetic; Genome; Genomics; Goals; Gold; Hour; Individual; Infrastructure; Internet; Intuition; Knowledge; Literature; Location; Maps; Methods; Mission; Modeling; Molecular; Newsletter; Nomenclature; Ontology; Organism; Orthologous Gene; Pathway interactions; Pharmaceutical Preparations; Phenotype; Plasmids; Procedures; Protocols documentation; Publications; Publishing; Quality Control; Records; Reference Standards; Research; Research Personnel; Research Support; Research Training; Resources; Role; Running; Secure; Ships; Signal Transduction; Site; Supervision; System; Taxonomy; Teaching Materials; Telephone; Time; Trust; United States National Institutes of Health; Update; Yeasts; base; cell motility; cloud based; comparative; comparative genomics; contig; dashboard; data curation; diverse data; expression vector; gene product; genome browser; human disease; improved; instructor; interest; microbial; model organisms databases; mutant; new technology; novel; online resource; operation; outreach; pathogen; preservation; reference genome; repository; response; search engine; teacher; tool; user-friendly

PROJECT SUMMARY The Dictyostelium Community Resource (DCR) is an integrated resource for investigators using Dictyostelium and related species for biomedical research and training. The DCR integrates two previously separately funded resources, dictyBase, the model organism database and the Dicty Stock Center, the strain and materials collection for Dictyostelids, to create a comprehensive community resource. The DCR is a combination of a computational and physical resource - each with separate roles but sharing infrastructure and user clientele. Given their related and interconnected goals, this integration of the two promotes efficiency, allowing users to obtain both curated information and research materials from the same organization. The DCR, widely supported by the research community, provides gold standard expert literature curation of genes, functional annotations using the Gene Ontology and a wide range of genomic resources in an intuitive and readily searchable online resource. Dictyostelium is widely used to study cellular processes such as cell motility, chemotaxis, signal transduction, cellular response to drugs, and host-pathogen interactions. Dictyostelium's genome contains significant orthologs of vertebrate, yeast and microbial genes, attracting researchers interested in a wide variety of biological topics including human disease, multicellular differentiation and comparative genomics. The DCR enables researchers to search, view and download up-to-date genomic, functional and technical information. It is also widely used by teachers/instructors due to the wealth of available teaching materials and research protocols. Dictyostelium investigators depend on dictyBase as their primary community resource, where help from dictyBase staff (DCR help line) or from other users (Dicty ListServ, moderated by the DCR) is available. We are in the final stages of deploying our completely new technology stack. By the end of this year dictyBase will be run entirely as a cloud-based application. This propoal seeks support the operation and expansion of this important community resource. Our goals for this proposal are: (Aim 1) Support the community of investigators using Dictyostelium and related species, (Aim 2) Provide scientific curation of D.discoideum and related species for community of investigators, (Aim 3) Maintain and distribute the strain collection; (Aim 4) Expand the Coverage of Species and Strains; (Aim 5) Improve Accessibility and Utility of the DCR. This support would build upon NIH funded resources by fully integrating and improving them.

项目概要 盘基网柄菌社区资源 (DCR) 是为使用盘基网柄菌的研究人员提供的综合资源 以及用于生物医学研究和培训的相关物种。 DCR 整合了两个先前单独资助的项目 资源，dictyBase，模式生物数据库和Dicty Stock Center，菌株和材料 收集盘基网柄科动物，创建一个全面的社区资源。 DCR 是一个组合 计算资源和物理资源——每个资源都有不同的角色，但共享基础设施和用户客户。 考虑到它们相关且相互关联的目标，两者的集成提高了效率，使用户能够 从同一组织获取精选信息和研究材料。 DCR，得到广泛支持 由研究界提供基因、功能注释的黄金标准专家文献管理 以直观且易于在线搜索的方式使用基因本体论和广泛的基因组资源 资源。盘基网柄菌广泛用于研究细胞运动、趋化性、信号等细胞过程 转导、细胞对药物的反应以及宿主-病原体相互作用。盘基网柄菌的基因组包含 脊椎动物、酵母和微生物基因的重要直系同源物，吸引了对各种领域感兴趣的研究人员 生物学主题包括人类疾病、多细胞分化和比较基因组学。直流电阻 使研究人员能够搜索、查看和下载最新的基因组、功能和技术信息。它 由于丰富的可用教学材料和研究，也被教师/讲师广泛使用 协议。盘基网柄菌调查人员依赖 dictyBase 作为他们的主要社区资源，在这里可以提供帮助 可以从 dictyBase 工作人员（DCR 帮助热线）或其他用户（Dicty ListServ，由 DCR 主持）获取。 我们正处于部署全新技术堆栈的最后阶段。到今年年底dictyBase 将完全作为基于云的应用程序运行。该提案寻求支持该项目的运营和扩展 重要的社区资源。我们此提案的目标是：（目标 1）支持研究人员社区 使用盘基网柄菌和相关物种，（目标 2）提供盘基网柄菌和相关物种的科学管理 对于研究人员群体，（目标 3）维护和分发菌株收集； （目标4）扩大覆盖范围 物种和品系； （目标 5）提高 DCR 的可访问性和实用性。这种支持将建立在 NIH 的基础上 充分整合和完善资助资源。