Biospecimen Core

生物样本核心

基本信息

批准号：
10628276
负责人：
Mark M. Pomerantz
金额：
$ 21.91万
依托单位：
DANA-FARBER CANCER INST
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10628276
关键词：
Acceleration Animal Model Antibodies Award Bar Codes Biocompatible Materials Biological Assay Biological Specimen Banks Biometry Biopsy Blood Cancer Center Cancer Patient Cellularity Clinical Clinical Data Collection Computational Biology Computer-Assisted Image Analysis Confidentiality of Patient Information Consent DNA Dana-Farber Cancer Institute Data Data Analyses Data Collection Data Management Resources Databases Development Ensure Equipment and supply inventories Evaluation Formalin Freezing Future General Hospitals Goals Hospitals Human Imaging technology Immunofluorescence Immunologic Immunohistochemistry Infrastructure Institution Israel Link Malignant neoplasm of prostate Massachusetts Medical center Molecular Molecular Analysis Outcome Paraffin Embedding Pathologic Pathology Patients Performance Pre-Clinical Model Procedures Process Prostate Prostatectomy Prostatic Neoplasms Proteins Protocols documentation Public Health Schools Quality Control RNA Research Personnel Research Project Grants Resources Sampling Secure Services Shipping Slide Specimen Stains Standardization System Technology Tissue Microarray Tissue Model Tissues Translational Research Validation Woman Work biobank cancer Biomedical Informatics Grid career clinical database experimental study human model human tissue laser capture microdissection mouse model neoplastic novel programs sample collection success tissue fixing tool tumor

项目摘要

PROJECT SUMMARY – BIOSPECIMEN CORE (CORE C) Acquisition and characterization of biospecimens linked with clinical data and the development of patient relevant preclinical models, are essential components for effective and impactful translational research. The Dana Farber/ Harvard Cancer Center (DF/HCC) Prostate SPORE Biospecimen Core (Core C) will maintain and expand a mature prostate cancer biorepository, including blood and tissue specimens, from a diverse group of prostate cancer patients across DF/HCC who have provided consent to our clinical database and biobank protocols. Core C will provide tissue specimens and vast pathology expertise to SPORE investigators including the evaluation of both human and mouse model tissues. Core C will maintain a database of clinical data on all consented patients, linked with standardized pathology review procedures and data collection. Core C will work closely with SPORE investigators and collaborators to provide interpretative and consultative pathology services, including stateoftheart molecular assays and imaging technologies developed at DF/HCC. Centralization of Core activities builds upon established infrastructure but does not replicate existing resources within the DF/HCC. Overall, Core C will greatly facilitate and accelerate translational research within the DF/HCC Prostate SPORE through the collection and integration of highly annotated biological material and associated clinical information.

项目摘要 – 生物标本核心（核心 C）与临床数据相关的生物样本的采集和表征以及开发患者相关的临床前模型是有效且有影响力的转化的重要组成部分达纳法伯/哈佛癌症中心 (DF/HCC) 前列腺 SPORE 生物样本核心（核心） C) 将维护和扩大成熟的前列腺癌生物样本库，包括血液和组织样本，来自 DF/HCC 的不同前列腺癌患者群体，他们已同意我们的临床数据库和生物库协议将提供组织标本和丰富的病理学专业知识。 SPORE 研究人员将对人类和小鼠模型组织进行评估。维护所有同意患者的临床数据数据库，并与标准化病理学审查相关联 Core C 将与 SPORE 研究人员和合作者密切合作，以完成程序和数据收集。提供解释和咨询病理学服务，包括最先进的分子检测 DF/HCC 开发的成像技术建立在核心活动的集中化之上。总体而言，核心 C 已建立基础设施，但不复制 DF/HCC 内的现有资源。将通过以下方式极大地促进和加速 DF/HCC 前列腺 SPORE 内的转化研究高度注释的生物材料和相关临床信息的收集和整合。