Core 4 - Rheumatic Diseases Research Informatics Core

核心 4 - 风湿性疾病研究信息学核心

• 批准号: 8688899
• 负责人: Michael Wagner
• 金额: $ 14.41万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8688899
• 关键词: Academic Medical Centers; Bioinformatics; Child; Childhood; Chronic Childhood Arthritis; Clinical; Clinical Research; Computer software; Custom; Data; Databases; Flow Cytometry; Foundations; Gene Chips; Gene Expression; Genetic; Genomics; Genotype; Informatics; Institution; Learning; Measures; Medical center; Medicine; Monitor; Online Systems; Pediatric Hospitals; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resource Informatics; Rheumatism; Rheumatology; Schedule; Secure; Services; Solutions; Stream; Surveys; base; biomedical informatics; college; computerized data processing; data acquisition; data management; design; genome wide association study; genome-wide; innovation; programs; ranpirnase; tool; user-friendly

The Rheumatic Disease Research Informatics Core (RIC, Informatics Core) provides biomedical informatics expertise and infrastructure to the Cincinnati Rheumatic Diseases Core Center (CRDCC) Research Base at the Cindrmati Ctiildren's Research Foundation (CCRF) of Cincinnati Children's Hospital Medical Center (CCHMC), and the University of Cindnnati College of Medicine (UCCOM). Research data management and bioinformatics analyses are essential components of rheumatology research programs at CCRF, espedaily as data streams from expression microarrays, flow cytometry and genotyping have increased. Investigators have learned to rely on easy, secure access to curated, reliable clinical and genomic data, as well as analysis tools. Access to informatics expertise through the Informatics Core will continue to enable the Research Base to imdertake large-scale, multi-institutional, data and processing-intensive research projects. While Informatics Core staff contribute their own background and expertise, they also see themselves as facilitators of access to the larger pool of informatics expertise at the institution (including the Division of Biomedical Informatics). Thus, the Informatics Core is the Research Base's gateway to state-of-the-art biomedical informatics support. The prindpal functions of the RIC are: � Provide research data management expertise and tools for the Research Base. This includes support for flow cytometry, expression and genetic microarray data and management, as well as design and implementation of clirucal research data acquisition tools. � Develop irmovative, web-based informatics solutions and bioiriformatics expertise to fadiitate integrative analysis of genomic data, including expression microarrays and genome-wide SNP data. The RIC proposes several significant enhancements to a GWADB (genome-wide association database), a custom-built web-based software application that has been at die center of genome-wide association studies (GWAS) for JIA undertaken in the Division of Rheumatology. Furthermore, the RIC will continue to support analyses of JIA gene expression data using state-of-the-art tools. Design and implement web-based, user-friendly informatics tools to measure and assure high quality and efficiency of CRDCC services. Part of this effort consists of deployment of user survey tools as well as monitoring tools that meeisure utilization of CRDCC services. Furthermore, the RIC develops billing and scheduling tools that increase accuracy and transparency of CRDCC services. The availability of the unique resource of the Informatics Core is essential to enabling defirutive genomic and dinical studies necessary to understand and define childhood rheumatic diseases.

风湿性疾病研究信息学核心（RIC，信息学核心）提供了生物医学Informati 辛辛那提风湿病核心中心（CRDCC）研究基础的专业知识和基础设施 辛辛那提儿童医院医疗中心的Cindrmati Cityren研究基金会（CCRF） （CCHMC）和辛纳蒂大学医学院（UCCOM）。研究数据管理和 生物信息学分析是CCRF风湿病研究计划的重要组成部分， 来自表达微阵列，流式细胞术和基因分型的数据流增加了。调查人员 已经学会了依靠轻松，安全的访问来策划，可靠的临床和基因组数据，以及分析 工具。通过信息核心获得信息专业知识的访问将继续使研究基础 以大规模，多机构，数据和处理密集型研究项目。尽管 信息学核心人员贡献了自己的背景和专业知识，他们也将自己视为促进者 可以在机构获得更大的信息专业知识（包括生物医学部门） 信息学）。那就是，信息学核心是研究基地的最先进生物医学的门户 信息支持。 RIC的prindpal功能是： �为研究基础提供研究数据管理专业知识和工具。这包括支持 用于流式细胞仪，表达和遗传微阵列数据和管理以及设计以及 Clirucal研究数据采集工具的实施。 �开发基于网络的知名度信息解决方案和生物形象专业知识，以淡出 基因组数据的综合分析，包括表达微阵列和全基因组SNP数据。 RIC提案对GWADB（全基因组关联）进行了几种显着增强 数据库），一种基于自定义的基于Web的软件应用程序，一直处于全基因组范围的中心 在风湿病学划分的JIA协会研究（GWAS）。此外， RIC将继续使用最先进的工具来支持对JIA基因表达数据的分析。 设计和实施基于网络的，用户友好的信息工具，以衡量和确保高质量 和CRDCC服务的效率。这项工作的一部分包括部署用户调查工具作为 以及监视CRDCC服务使用的工具。此外，RIC的发展 计费和调度工具，以提高CRDCC服务的准确性和透明度。 信息核心核心独特资源的可用性对于使缺乏基因组不足至关重要 以及了解和定义儿童风湿病所必需的数字研究。