Rheumatology Informatics Core

风湿病学信息学核心

• 批准号: 9171182
• 负责人: Michael Wagner
• 金额: $ 12.96万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9171182
• 关键词: Academic Medical Centers; Autoimmune Process; Basic Science; Biocompatible Materials; Bioinformatics; Cells; Child; Childhood; Clinic; Clinical; Clinical Data; Clinical Research; Communities; Computer Analysis; Computer software; Computerized Medical Record; Consent; Consultations; Data; Databases; Diagnosis; Foundations; Genes; Genetic; Genetic Predisposition to Disease; Genomics; Housing; Individual; Informatics; Institution; Laboratories; Learning; Link; Medical; Medical Records; Medical center; Medicine; Methodology; Nucleic Acid Regulatory Sequences; Patients; Pattern; Pediatric Hospitals; Process; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resource Informatics; Resources; Rheumatism; Rheumatology; Secure; Services; Stream; System; Technology; Universities; Variant; biomedical informatics; college; computerized data processing; data acquisition; data integration; data management; design; electronic data; exome; functional genomics; genetic variant; genomic data; innovation; insight; knowledge base; member; next generation sequencing; programs; ranpirnase; tool; transcriptome sequencing; web-based informatics; whole genome

The Rheumatology Informatics Core (RIC, Informatics Core) provides biomedical informatics expertise and infrastructure to the Cincinnati Rheumatic Diseases Resource Center (CRDRC) Research Community at the Cincinnati Children's Research Foundation (CCRF) of Cincinnati Children's Hospital Medical Center (CCHMC), and the University of Cincinnati College of Medicine (UCCOM). Research data management and bioinformatics analyses are essential components of rheumatology research programs at CCRF and UC, especially as data streams from next-generation sequencing (NGS) technologies combined with biomaterial tracking, laboratory data and medical records data have increased. Investigators have learned to rely on easy, secure access to curated, reliable clinical and genomic data, as well as analysis tools. Access to informatics expertise through the Informatics Core will continue to enable the Research Community to undertake large-scale, multi-institutional, data and processing-intensive research projects. While Informatics Core staff contribute their own background and expertise, they also see themselves as facilitators of access to the larger pool of informatics expertise at the institution (including the Division of Biomedical Informatics (BMI) and the Center for Autoimmune Genetics and Etiology (CAGE)). Thus, the Informatics Core is the Research Community's gateway to state-of-the-art biomedical informatics support. The principal functions of the RIC are: • To provide research data management expertise and tools for the Research Community. This includes support for next generation sequencing (Exome, Whole-Genome and RNAseq) data and management, as well as design and implementation of clinical research data acquisition tools which will provide the Rheumatology Research Community with a single, unified query interface for data in the Epic Electronic Medical Record System, the Biomaterials Tracking and Management (BTM) System, the REDCap Electronic Data Capture System as well as the in-house CCHMC Variant Knowledgebase.. • To develop innovative, web-based informatics solutions and bioinformatics expertise to facilitate integrative analysis of genomic data, including NGS data. The RIC will build synergistically on CCHMC's Center for Pediatric Genomics (CpG) iniative, which is implementing software infrastructure to manage, process and interpret genomic variant information from NGS data. Furthermore, the RIC will continue its partnership with Dr. Mario Medvedovic at the University of Cincinnati to provide state-of-the-art analysis methodology for single cell RNAseq data. The availability of the unique resource of the Informatics Core is essential to enabling definitive genomic and clinical studies necessary to understand and define childhood rheumatic diseases.

风湿病信息学核心（RIC，信息学核心）提供生物医学信息专业知识 和辛辛那提风湿病资源中心（CRDRC）研究社区的基础设施 在辛辛那提儿童医院医疗中心的辛辛那提儿童研究基金会（CCRF） （CCHMC）和辛辛那提大学医学院（UCCOM）。研究数据管理和 生物信息学分析是CCRF和UC的风湿病研究计划的重要组成部分， 特别是当来自下一代测序（NGS）技术与生物材料结合的数据流 跟踪，实验室数据和医疗记录数据有所增加。调查人员学会了依靠 轻松，安全地访问精选，可靠的临床和基因组数据以及分析工具。访问 通过信息学核心的信息专业知识将继续使研究界能够 进行大规模，多机构，数据和处理密集型研究项目。同时信息学 核心人员贡献自己的背景和专业知识，他们还认为自己是访问的促进者 到该机构的更大信息专业知识（包括生物医学信息学系 （BMI）和自身免疫性遗传学和病因（笼））。那就是信息学核心是 研究界向最先进的生物医学信息提供支持的门户。 RIC的主要功能是： •为研究社区提供研究数据管理专业知识和工具。这 包括支持下一代测序（外显子，全基因组和RNASEQ）数据，以及 管理以及临床研究数据采集工具的设计和实施 将为风湿病研究社区提供一个单一的，统一的查询界面，以供数据 史诗般的电子病历系统，生物材料跟踪和管理（BTM） 系统，REDCAP电子数据捕获系统以及内部CCHMC变体 知识库.. •开发创新的基于网络的信息解决方案和生物信息学专业知识以促进 基因组数据的综合分析，包括NGS数据。 RIC将协同建立 CCHMC的小儿基因组学中心（CPG）Intiative，正在实施软件 从NGS数据中管理，处理和解释基因组变体信息的基础架构。 此外，RIC将继续与大学的Mario Meddedovic博士合作 辛辛那提提供了单细胞RNASEQ数据的最新分析方法。 信息核心核心独特资源的可用性对于启用确定基因组和 了解和定义儿童风湿病所必需的临床研究。