Stress, Binge Eating, and Metabolic Abnormalities

压力、暴饮暴食和代谢异常

• 批准号: 8645230
• 负责人: ARIANA MARIE CHAO
• 金额: $ 4.27万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8645230
• 关键词: Accounting; Address; Adult; Age; Attention; Behavior; Behavioral; Binge Eating; Carbohydrates; Central obesity; Characteristics; Chronic; Complex; Consumption; Coronary heart disease; Data; Data Analyses; Discipline of Nursing; Early-life trauma; Eating Behavior; Educational process of instructing; Effectiveness; Energy Intake; Epidemic; Equation; Event; Fatty acid glycerol esters; Feeling; Fellowship; Food; Foundations; Gender; Goals; Health; Health Promotion; High Prevalence; Homeostasis; Hydrocortisone; Hyperglycemia; Hyperlipidemia; Hypertriglyceridemia; Hypothalamic structure; Individual; Influentials; Insulin Resistance; Interdisciplinary Study; Intervention; Knowledge; Link; Literature; Mediating; Mediator of activation protein; Metabolic; Metabolic stress; Mission; Modeling; National Institute of Nursing Research; Non-Insulin-Dependent Diabetes Mellitus; Nurses; Obesity; Outcome; Pathway interactions; Patient Self-Report; Physiological; Pituitary Gland; Prevalence; Preventive Intervention; Process; Psychiatry; Psychology; Research; Research Personnel; Risk; Scientist; Self-control as a personality trait; Societies; Socioeconomic Status; Solutions; Stress; Stress and Coping; Stroke; Testing; Therapeutic; Therapeutic Intervention; Time; Training; United States; abdominal fat; addiction; biobehavior; career; coping; disorder prevention; effective intervention; experience; obesity prevention; obesity treatment; prevent; programs; psychosocial; public health relevance; response; skills; steroid hormone; theories; treatment strategy

DESCRIPTION (provided by applicant): Currently, 78 million U.S. adults are obese and little progress has been made in reducing the number of individuals with this complex problem. The most serious consequences of obesity are metabolic abnormalities, which are the major predictors of coronary heart disease, stroke, and type 2 diabetes. It is crucial for the well being of individuals and society to develop effective interventions, but this can only be done once specific intervention targets are identified. To that end, the purpose of this fellowship applicatin is to provide vital training experiences so that the candidate can develop the knowledge and skills necessary to become a strong nurse researcher with considerable and growing expertise in obesity, binge eating, structural equation modeling, and biobehavioral research. This foundation is necessary to accomplish the candidate's long-term career objective of becoming an independent and productive nurse scientist who contributes solutions to the obesity epidemic. As part of the training plan, the candidate will conduct a secondary data analysis to examine the biobehavioral pathways linking stress to metabolic abnormalities-a well-recognized link, but with mechanisms that are unclear. One mechanism that would account for how and why the relationship between stress and metabolic abnormalities occurs is binge eating. Though there is strong theoretical support for the idea that binge eating mediates the relationship between stress and metabolic abnormalities, empirical testing is necessary. Thus, the specific aims of this study are to: 1) Identify the relationships among self-reports of stress (early trauma and chronic, recent, and perceived stress), binge eating, and metabolic abnormalities in adults, 2) identify the relationships among self-reports of stress, the cortisol awakening response, binge eating, and metabolic abnormalities in adults; and 3) explore moderators (age, gender, and socioeconomic status) of these relationships. This study will use data collected from the Interdisciplinary Research Consortium on Stress, Self-Control, and Addiction (PL1-DA024859 and UL1- DE019859), and will be analyzed using structural equation modeling. The candidate will also participate in a unique combination of coursework, research, and teaching experiences to help her achieve her training goals. This proposal addresses the National Institute of Nursing Research's mission of enhancing health promotion and disease prevention, as the knowledge gained from this study will provide specific targets for preventative and therapeutic obesity interventions. Furthermore, this study will serve as the first step in a broader research program to more fully understand the complexities of binge eating and obesity, and to develop interventions to prevent and treat binge eating and obesity in people of all ages.

描述（由申请人提供）：目前，有7800万美国成年人肥胖，减少有这个复杂问题的人数几乎没有取得进展。肥胖症最严重的后果是代谢异常，这是冠心病，中风和2型糖尿病的主要预测因素。这对于福利至关重要 个人和社会制定有效的干预措施，但只有确定了特定的干预目标，才能进行。为此，该奖学金应用的目的是提供重要的培训经验，以便候选人能够发展出具有肥胖，暴饮暴食，结构方程建模和生物行为研究的强大专业知识所必需的知识和技能。该基础对于完成候选人的长期职业目标是必不可少的，即成为一名独立和富有成效的护士科学家，他们为肥胖症流行贡献解决方案。作为培训计划的一部分，候选人将进行二级数据分析，以检查将应力与代谢异常联系起来的生物行为途径 - 良好认可的联系，但与尚不清楚的机制。一种机制可以说明压力和代谢异常之间的关系是如何以及为什么发生的一种机制是暴饮暴食。尽管对暴饮暴食介导压力和代谢异常之间关系的想法有强烈的理论支持，但经验测试是必要的。因此，本研究的具体目的是：1）确定压力自我报告（早期创伤和慢性，最近和感知的压力），狂饮饮食和成人的代谢异常，2）确定压力自我报告之间的关系3）探索这些关系的主持人（年龄，性别和社会经济地位）。这项研究将使用从跨学科研究联盟收集的有关压力，自我控制和成瘾的研究（PL1-DA024859和UL1- DE019859），并将使用结构方程建模进行分析。候选人还将参与课程，研究和教学经验的独特组合，以帮助她实现培训目标。该建议涉及美国国家护理研究所（National Surtraning Research）提高健康促进和疾病预防的使命，因为这项研究所获得的知识将为预防和治疗性肥胖干预提供具体的目标。此外，这项研究将作为更广泛的研究计划的第一步，以更充分地了解暴饮暴食和肥胖的复杂性，并制定干预措施，以预防和治疗各个年龄段的人的暴饮暴食和肥胖症。