Pancreatic Ductal Adenocarcinoma Translational Resource Center (PATReC)

胰腺导管腺癌转化资源中心 (PATReC)

• 批准号: 10242451
• 负责人: ANIRBAN MAITRA
• 金额: $ 56万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10242451
• 关键词: Administrative Coordination; Algorithms; Antigens; Archives; Area; Bioinformatics; Biological; Biology; Biometry; Cancer Center; Cancer Etiology; Cataloging; Catalogs; Cell Line; Cessation of life; Clinical Management; Clinical Research; Clinical Trials; Clinical Trials Data Monitoring Committees; Collection; Communication; Companions; Complex; Computational Biology; Credentialing; Data; Data Analyses; Data Storage and Retrieval; Diagnosis; Disease; Disease model; Elements; Enrollment; Ensure; Facility Accesses; Funding; Goals; Immune; Immunofluorescence Immunologic; Immunologic Monitoring; Immunotherapeutic agent; Immunotherapy; Incidence; Individual; Infrastructure; Innovative Therapy; Institution; Intervention; Investigational Therapies; Laboratory Research; Lead; Logistics; Malignant Neoplasms; Manuals; Methodology; Modality; Molecular; Molecular Profiling; Organ; Organoids; Pancreatic Ductal Adenocarcinoma; Participant; Pathologic; Pathologist; Pathology; Patients; Persons; Play; Procedures; Reagent; Research Design; Research Personnel; Resources; Role; Secure; Services; Site; Solid; Standardization; Survival Rate; Teleconferences; Therapeutic; Tissue Microarray; Tissues; Translational Research; Treatment Efficacy; United States; Xenograft procedure; automated image analysis; base; biobank; cancer biomarkers; cancer genomics; cancer immunotherapy; clinically relevant; comparative efficacy; computerized tools; data dissemination; data exchange; data management; data tools; design; immune function; improved; innovation; material transfer agreement; meetings; member; mortality; multidisciplinary; operation; outcome forecast; pre-clinical; preclinical study; programs; prospective; response; stem; synergism; targeted treatment; tool; translational study; tumor microenvironment; tumor progression; virtual; web portal; web site

ABSTRACT In contrast to the decline in mortality in other cancers, the incidence of pancreatic ductal adenocarcinoma (PDAC) is increasing, and therapeutic approaches, for the most part, have not been successful at improving survival in patients. Although recent advances in immunotherapy have shown efficacy in various solid cancers, comparable efficacy in PDAC has been limited by a complex tumor microenvironment (TME) that creates an immune suppressive milieu ripe for tumor progression. Thus, bold interventions that can overcome immune barriers in the PDAC TME are urgently needed to reduce the mortality stemming from this recalcitrant disease. The U01 “Consortium for PDAC Translational Studies on the TME” was created through the National Cancer Moonshot initiative to accelerate the pace of progress in innovative therapies targeting the TME in PDAC, especially those geared towards immune-based modalities. Our proposal is in response to the companion U24 RFA to create a resource center for the five funded Consortium sites, which we call Pancreatic Ductal Adenocarcinoma Translational Resource Center (PATReC). The PATReC will be co-led by Drs. Ignacio Wistuba and Anirban Maitra, two established molecular pathologists at UT MD Anderson Cancer Center (UTMDACC) with long-standing expertise in cancer biomarkers, tissue based molecular profiling, and with respect to one co-leader (AM), specific expertise in PDAC biology, disease models and experimental therapeutics. They will be supported by an exceptional supporting cast, including Drs. Jack Lee (biostatistics), Andy Futreal (cancer genomics and computational biology), Jason Roszik (bioinformatics) and Stan Hamilton (co-leader of the NCI MATCH biorepository). The overall goal is to support the consortium efforts in multiple areas including: providing an administrative infrastructure for coordinated interactions amongst the U01 awardees; facilitating centralized biospecimen banking and distribution; enabling centralized data storage capabilities; and credentialed biostatistics and bioinformatics support with the ultimate goal of designing translationally relevant combination interventions targeting the TME in PDAC. In Aim 1, we will support administrative coordination amongst the U01 sites by ensuring effective communication, cooperation, and access to rapid data exchange that will advance the goals of the individual Consortium sites. The PATReC will serve as the central “hub” for virtual and in-person communication across the entire Consortium. In Aim 2, we will utilize our unique institutional infrastructure to provide centralized data management services that will be readily accessible to all Consortium sites via a secure website, and provide bioinformatics and biostatics services for the analyses and interpretation of data. In Aim 3, we will standardize bio-banking activities and develop standard operation procedures (SOPs) for biospecimen collection, processing and distribution, as well as provide access to biologically relevant PDAC preclinical resources. We envision that the PATReC will be an indispensable element as we make meaningful progress towards targeting the TME in this lethal disease.

抽象的 与其他癌症死亡率下降相反，胰腺导管腺癌的发病率 (PDAC) 正在增加，而大多数治疗方法并未成功改善 尽管免疫疗法的最新进展已显示出对各种实体癌的疗效， PDAC 的可比疗效受到复杂的肿瘤微环境 (TME) 的限制，该环境产生了 因此，大胆的干预措施可以克服​​免疫抑制。 迫切需要 PDAC TME 中的屏障来降低这种顽固性疾病引起的死亡率。 U01“PDAC TME 转化研究联盟”是通过国家癌症中心创建的 Moonshot 计划旨在加快针对 PDAC 中 TME 的创新疗法的进展步伐， 特别是那些针对基于免疫的模式的建议是为了回应同伴 U24。 RFA 将为五个资助的联盟站点创建一个资源中心，我们称之为胰腺导管 腺癌转化资源中心 (PATReC) 将由 Ignacio 博士共同领导。 Wistuba 和 Anirban Maitra，UT MD 安德森癌症中心的两位知名分子病理学家 (UTMDACC) 在癌症生物标志物、基于组织的分子分析方面拥有长期的专业知识，并且 尊敬一位联合领导者 (AM)，在 PDAC 生物学、疾病模型和实验方面具有特定的专业知识 他们将得到杰出支持人员的支持，包括杰克·李博士（生物统计学）， Andy Futreal（癌症基因组学和计算生物学）、Jason Roszik（生物信息学）和 Stan Hamilton （NCI MATCH 生物库联合领导者）总体目标是支持联盟在多个方面的努力。 领域包括： 为 U01 之间的协调互动提供管理基础设施 奖励；促进集中生物样本银行和分发；实现集中数据存储； 能力；以及经过认证的生物统计学和生物信息学支持，以实现设计的最终目标 在目标 1 中，我们将支持针对 PDAC 中 TME 的转化相关组合干预措施。 U01 站点之间的行政协调，确保有效的沟通、合作和 访问快速数据交换将推进各个联盟站点的目标。 在目标 2 中，我们作为整个联盟的虚拟和面对面交流的中心“枢纽”。 将利用我们独特的机构基础设施来提供集中数据管理服务 通过安全网站可轻松访问所有联盟网站，并提供生物信息学和生物统计学 在目标 3 中，我们将标准化生物银行活动和数据分析和解释服务。 制定生物样本采集、处理和分发的标准操作程序 (SOP) 提供获取生物学相关的 PDAC 临床前资源的机会。我们预计 PATReC 将是 当我们在针对这种致命疾病的 TME 方面取得有意义的进展时，这是一个不可或缺的因素。