TBEL Admin Core

TBEL 管理核心

• 批准号: 10518936
• 负责人: ANIRBAN MAITRA
• 金额: $ 15.17万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-21 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10518936
• 关键词: Adherence; Administrator; Advocacy; Advocate; Agreement; Awareness; Biometry; Budgets; Cancer Center; Collaborations; Communication; Communities; Consultations; Data; Decision Making; Doctor of Philosophy; Ensure; Foundations; Funding; Goals; Grant; Human Resources; Hybrids; Information Dissemination; Institution; Lead; Leadership; Lesion; Malignant Neoplasms; Malignant neoplasm of pancreas; Manuscripts; Michigan; Molecular Biology; Monitor; Oncology; Pancreas; Pancreatic Adenocarcinoma; Patients; Persons; Preparation; Progress Reports; Publications; Regulation; Reporting; Research; Research Activity; Research Personnel; Resource Sharing; Schedule; Science; Site; Site Visit; Time; Transfer Agreement; Universities; University of Texas M D Anderson Cancer Center; Update; Wood material; anticancer research; base; career; data integrity; data management; data resource; design; experience; implementation facilitation; material transfer agreement; meetings; member; molecular pathology; operation; pancreatic neoplasm; professor; programs; quality assurance; tumor microenvironment; virtual; web site; working group

ADMINISTRATIVE CORE - Abstract The Administrative Core (AC) will provide all of the administrative and communications support to the Tri-State Pancreatic Adenocarcinoma TBEL (Tri-PACT) Center investigators, and form the central “hub” for productive interactions within the NCI TBEL community. The title of our Tri-PACT Center proposal is “Tumor Microenvironment Crosstalk Drives Early Lesions in Pancreatic Cancer”, and our Center incorporates three institutions – UT MD Anderson cancer Center (UTMDACC), University of Michigan (UMich) and Johns Hopkins University (JHU) in a collaborative and integrated U54 endeavor to study early pancreatic neoplasia. The Tri- PACT Center AC will be led by overall Contact PI, Dr. Anirban Maitra, and Co-PI Dr. Marina Pasca di Magliano, and housed within the Sheikh Ahmed Center for Pancreatic Cancer Research at UTMDACC. The AC will be supported by a PhD-level Core Administrator with experience with multi-investigator grants. Further, Dr. Yu Shen, Professor and Chair ad interim of Biostatistics at UTMDACC, will provide comprehensive statistical support for the Tri-PACT Center and will be assisted by a senior statistical analyst. Dr. Maitra and the AC have considerable experience in overseeing and participating in multi-investigator grants that include programmatic NCI U01, P01 and P50 Grants. The overall goals of the AC will be (a) to monitor research progress and to provide stable and continuous leadership that advances integration, communication, and collaboration among the Tri-PACT Center investigators participating in the three proposed projects and shared resource core (Multiscale Computational Oncology Research Core or M-CORE), and (b) to ensure productive interactions with other concurrently funded TBEL U54 sites and the TBEL CDMC, through formal and informal collaborative endeavors under the TBEL umbrella. The AC will leverage the wide-ranging research expertise of both the Internal Advisory Board (IAB) and the External Advisory Board (EAB) in critical decision-making steps, such as changes in research directions of currently proposed projects. The AC will ensure fiscal management, including personnel, budgets, and effort oversight, facilitate organization of virtual and in-person work-in-progress meetings for Tri-PACT center investigators, engage in manuscript preparation, and provide federally mandated progress and other reports to the NCI. The AC will facilitate attendance for the PIs and Tri-PACT investigators to the semi-annual TBEL consortium meetings, and ensure our participation in other network activities, including TBEL working groups, trans-network collaborations, and dissemination of results within and beyond the TBEL community. The AC will serve as a liaison with the TBEL CDMC in ensuring the transfer of TriPACT Center- generated data and materials under appropriate transfer agreements. The AC will also ensure timely communication and consultation with the NCI Program Directors for both adherence and deviations from stated programmatic goals. Last but not the least, the AC will also enhance awareness of pancreatic cancer early lesion research and advocacy in the community through public-facing websites and and publications.

行政核心 - 摘要 行政核心 (AC) 将为三州提供所有行政和通信支持 胰腺癌 TBEL (Tri-PACT) 中心研究人员，形成生产力的中心“枢纽” NCI TBEL 社区内的互动 我们的 Tri-PACT 中心提案的标题是“肿瘤”。 “微环境串扰驱动胰腺癌早期病变”，我们的中心包括三个 机构 – UT MD 安德森癌症中心 (UTMDACC)、密歇根大学 (UMich) 和约翰霍普金斯大学 大学 (JHU) 与 U54 合作，致力于研究早期胰腺肿瘤。 PACT Center AC 将由总联系人 PI Anirban Maitra 博士和联合 PI 博士 Marina Pasca di Magliano 领导， AC 将设在 UTMDACC 谢赫艾哈迈德胰腺癌研究中心内。 由具有多研究者资助经验的博士级核心管理员支持。 UTMDACC 生物统计学教授兼临时主席 Shen 将提供全面的统计数据 高级统计分析师 Maitra 博士和 AC 将为 Tri-PACT 中心提供支持。 在监督和参与多研究者资助（包括计划性资助）方面拥有丰富的经验 NCI U01、P01 和 P50 赠款 AC 的总体目标是 (a) 监测研究进展并 提供稳定、持续的领导力，促进内部整合、沟通和协作 参与三个拟议项目和共享资源核心的 Tri-PACT 中心研究人员 （多尺度计算肿瘤学研究核心或 M-CORE），以及 (b) 确保与 其他同时资助的 TBEL U54 站点和 TBEL CDMC，通过正式和非正式的合作 AC 将利用双方广泛的研究专业知识。 内部顾问委员会 (IAB) 和外部顾问委员会 (EAB) 参与关键决策步骤，例如 审计委员会将确保当前拟议项目的研究方向发生变化，包括财务管理。 人员、预算和监督工作，促进虚拟和现场正在进行的工作的组织 与 Tri-PACT 中心调查员举行会议，参与稿件准备，并提供联邦授权的 AC 将协助 PI 和 Tri-PACT 调查员出席。 参加半年一次的 TBEL 联盟会议，并确保我们参与其他网络活动，包括 TBEL 工作组、跨网络合作以及 TBEL 内外成果的传播 AC 将作为 TBEL CDMC 的联络人，确保 TriPACT 中心的转移。 审计委员会还将确保及时根据适当的转让协议生成数据和材料。 与 NCI 项目主管就遵守和偏离规定进行沟通和协商 最后但并非最不重要的一点是，AC 还将提高人们对早期胰腺癌的认识。 通过面向公众的网站和出版物在社区进行病变研究和宣传。