Developmental Research Program
发展研究计划
基本信息
- 批准号:10226091
- 负责人:
- 金额:$ 24.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-08-20 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AreaAwardBasic ScienceBudgetsCancer CenterClinicalClinical InvestigatorCollaborationsColorectal CancerCommunitiesCommunity DevelopmentsComplementDataDevelopmentDirect CostsDisciplineDiseaseEducational ActivitiesEnvironmentEvaluationFinancial SupportFundingFutureGoalsGuidelinesHumanIncidenceInstitutionLaboratoriesLeadLeadershipLettersMalignant NeoplasmsMalignant neoplasm of gastrointestinal tractMalignant neoplasm of pancreasMedical OncologyMedical centerMinority GroupsModelingMonitorNational Cancer InstituteNaturePathologyPatientsPhysiciansPilot ProjectsPlant RootsPopulation ResearchPrincipal InvestigatorProcessProgram Research Project GrantsQuality of lifeRecordsResearchResearch ActivityResearch PersonnelResearch Project GrantsResourcesRestRouteScientistSelection CriteriaSpecimenTexasTextTranslational ResearchTranslationsUnderrepresented MinorityUnited States National Institutes of HealthUniversitiesWomanWorkanticancer researchbaseflexibilitygastrointestinalhigh riskimprovedinnovationmembermid-career facultymolecular pathologymortalitypatient populationprofessorprogramsrecruitsoundtranslational cancer researchtranslational study
项目摘要
DEVELOPMENTAL RESEARCH PROGRAM: Summary/Abstract
The purpose of the Developmental Research Program (DRP) is to fund highly innovative translational studies in
colorectal cancer (CRC) or pancreatic cancer (PDAC) that currently lack a human endpoint as mandated by the
SPORE guidelines, but that could become full SPORE projects with requisite DRP support, or compete
successfully for funding outside of the SPORE mechanism. The DRP provides a unique venue for making
available critical financial support, as well as disease-specific intellectual and resource expertise, through a
program that is rapidly responsive to new ideas or initiatives, including from investigators whose current work
may not focus exclusively in CRC or PDAC research. This program is rooted in a spirit of collaboration espoused
by the GI SPORE leadership, which has an extensive track record of bringing investigators from other disciplines
into the field of CRC and/or PDAC research. The strength of the DRP rests in its ability to make available financial
support needed to access all the critical expertise and resources within the entire GI SPORE, including the
proposed Cores. This will allow us to develop innovative, investigator-initiated projects that have the potential to
flourish into reliable and productive translational research projects along a path from basic and/or population
research projects into research focused on human clinical specimens/patient populations. The DRP will be co-
led by principal investigators of the SPORE including Dr. Anirban Maitra, the Scientific Director of the Sheikh
Ahmed Center for Pancreatic Cancer Research, and Professor in the Departments of Pathology and
Translational Molecular Pathology at UT MD Anderson Cancer Center (UTMDACC) and Dr. Scott Kopetz,
Associate Professor and Deputy Chair for Translational Research in the Department of Gastrointestinal Medical
Oncology. The DRP will incorporate not only UTMDACC, but also our collaborating partner institution Johns
Hopkins University (JHU) and other centers of excellence within the Texas Medical Center, providing an
unprecedented seedbed for promoting innovative translational research projects in PDAC and CRC. Pre-
proposals in the form of one page letters of intent (LOI) will be solicited by the Program, and following review by
the DRP leadership, applicants of the responsive pre-proposals will be invited to submit a full proposal for review.
The DRP Directors will help investigators submitting proposals to formulate translational research aims and plans
relevant to the overall themes of the GI SPORE, as many applicants may not have prior expertise in this type of
research. The overarching goal will be to facilitate research activities that will enable proposing a feasible human
endpoint for future iterations of the funded proposal. This process will therefore be a major educational activity
that is further anticipated to stimulate translational research in CRC or PDAC and encourage the participation of
both basic science researchers and clinical investigators in translational research.
发展研究计划:摘要/摘要
发展研究计划(DRP)的目的是资助以下领域的高度创新的转化研究:
结直肠癌 (CRC) 或胰腺癌 (PDAC) 目前缺乏 FDA 规定的人类终点
SPORE 指南,但这可能成为具有必要的 DRP 支持的完整 SPORE 项目,或者竞争
成功获得 SPORE 机制之外的资金。 DRP 提供了一个独特的场所
可用的关键财政支持,以及特定疾病的知识和资源专业知识,通过
能够快速响应新想法或倡议的计划,包括来自当前工作的研究人员的想法或倡议
可能不仅仅专注于 CRC 或 PDAC 研究。该计划植根于所倡导的合作精神
由 GI SPORE 领导层负责,该领导层在吸引其他学科的研究人员方面拥有广泛的记录
进入 CRC 和/或 PDAC 研究领域。 DRP 的优势在于其提供可用资金的能力
获得整个 GI SPORE 内所有关键专业知识和资源所需的支持,包括
建议的核心。这将使我们能够开发由研究者发起的创新项目,这些项目有可能
沿着从基础和/或人口的道路发展成可靠和富有成效的转化研究项目
研究项目集中于人类临床标本/患者群体的研究。 DRP 将共同
由 SPORE 的主要研究者领导,其中包括 Sheikh 的科学总监 Anirban Maitra 博士
艾哈迈德胰腺癌研究中心,病理学系和
UT MD 安德森癌症中心 (UTMDACC) 的转化分子病理学和 Scott Kopetz 博士,
胃肠医学系副教授兼转化研究副主席
肿瘤学。 DRP 不仅将纳入 UTMDACC,还将纳入我们的合作伙伴机构 Johns
霍普金斯大学 (JHU) 和德克萨斯医学中心内的其他卓越中心,提供
为促进 PDAC 和 CRC 创新转化研究项目提供了前所未有的土壤。预
该计划将征求一页意向书 (LOI) 形式的提案,并由
DRP 领导层将邀请响应性预提案的申请人提交完整的提案以供审核。
DRP主任将帮助研究人员提交提案以制定转化研究目标和计划
与 GI SPORE 的总体主题相关,因为许多申请人可能不具备此类方面的专业知识
研究。总体目标是促进研究活动,从而提出可行的人类方案
资助提案未来迭代的终点。因此,这个过程将是一项重大的教育活动
预计将进一步刺激 CRC 或 PDAC 的转化研究并鼓励
转化研究中的基础科学研究人员和临床研究人员。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ANIRBAN MAITRA其他文献
ANIRBAN MAITRA的其他文献
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{{ truncateString('ANIRBAN MAITRA', 18)}}的其他基金
Tumor Microenvironment Crosstalk Drives Early Lesions in Pancreatic Cancer
肿瘤微环境串扰导致胰腺癌早期病变
- 批准号:
10708199 - 财政年份:2022
- 资助金额:
$ 24.84万 - 项目类别:
Tumor Microenvironment Crosstalk Drives Early Lesions in Pancreatic Cancer
肿瘤微环境串扰导致胰腺癌早期病变
- 批准号:
10518935 - 财政年份:2022
- 资助金额:
$ 24.84万 - 项目类别:
Translational Applications in an Animal Model of Pancreatic Cystic Neoplasm and Cancer
胰腺囊性肿瘤和癌症动物模型中的转化应用
- 批准号:
9904574 - 财政年份:2018
- 资助金额:
$ 24.84万 - 项目类别:
Wnt/?-catenin Signaling in Pancreatic Oncogenesis
胰腺肿瘤发生中的 Wnt/β-catenin 信号转导
- 批准号:
9565530 - 财政年份:2017
- 资助金额:
$ 24.84万 - 项目类别:
Wnt/?-catenin Signaling in Pancreatic Oncogenesis
胰腺肿瘤发生中的 Wnt/β-catenin 信号转导
- 批准号:
10621802 - 财政年份:2017
- 资助金额:
$ 24.84万 - 项目类别:
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