EFFECT OF DIETARY CALCIUM IN ADULTS

膳食钙对成人的影响

• 批准号: 7731418
• 负责人: MACIEJ S BUCHOWSKI
• 金额: $ 0.47万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731418
• 关键词: Adipocytes; Adult; Affect; Blood; Body Weight; Body Weight decreased; Calcitonin; Calcitriol; Calcium; Computer Retrieval of Information on Scientific Projects Database; Diet; Dietary Calcium; Energy Metabolism; Equilibrium; Excretory function; Fatty acid glycerol esters; Feces; Funding; Goals; Grant; Hormones; Human; Institution; Methods; Prevention; Research; Research Personnel; Resources; Source; Stream; Supplementation; Thyroid Gland; United States National Institutes of Health; Vitamin D; extracellular; lipid metabolism; obesity treatment

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It has been shown that intracellular calcium (Ca) is a regulating factor in fat metabolism in humans. Increases in intracellular Ca cause an increase in fat storage and a decrease in fat utilization. Methods to regulate intracellular Ca in fat cells may be a new strategy in the prevention and/or treatment of obesity. The active form of vitamin D, calcitriol, stimulates an increase in intracellular Ca. By suppressing calcitriol, intracellular Ca will decrease causing an increase in fat utilization. One mechanism that causes the suppression of calcitriol is by increasing dietary Ca. By increasing the amount of extracellular Ca in the blood stream, the thyroid gland is stimulated to release calcitonin, which is a hormone that suppresses calcitriol. Dietary calcium could also cause excretion of unabsorbed fat in stool. This study will examine the effect of calcium supplementation and energy restriction on weight loss. Our goal is to determine how dietary calcium in combination with energy deficit affects energy metabolism and balance, body weight and composition, and lipid metabolism. The specific aims of the proposed research are: 1. To determine how high calcium diet affects energy metabolism and balance. 2. To determine how high calcium diet affects body weight and composition. 3. To explain how dietary calcium affects lipid metabolism.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 研究表明，细胞内钙（Ca）是人体脂肪代谢的调节因子。细胞内钙的增加导致脂肪储存增加和脂肪利用率下降。调节脂肪细胞内Ca 的方法可能是预防和/或治疗肥胖的新策略。维生素 D 的活性形式骨化三醇可刺激细胞内 Ca 的增加。通过抑制骨化三醇，细胞内钙会减少，导致脂肪利用率增加。抑制骨化三醇的一种机制是增加膳食钙。通过增加血流中细胞外钙的含量，刺激甲状腺释放降钙素，这是一种抑制骨化三醇的激素。膳食钙还可能导致粪便中未吸收的脂肪排出。这项研究将探讨补钙和能量限制对减肥的影响。我们的目标是确定膳食钙与能量不足如何影响能量代谢和平衡、体重和成分以及脂质代谢。 拟议研究的具体目标是： 1. 确定高钙饮食如何影响能量代谢和平衡。 2. 确定高钙饮食对体重和成分的影响程度。 3. 解释膳食钙如何影响脂质代谢。