Innate Immunity Training Program

先天免疫训练计划

• 批准号: 8152421
• 负责人: Neal Silverman
• 金额: $ 12.8万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8152421
• 关键词: Natural Immunity; Training Programs

DESCRIPTION (provided by applicant): Our understanding of the impact and workings of the innate immune system has increased exponentially in the past 15 years. Innate immunity is now a complex discipline that encompasses a variety of topics ranging from innate immune receptor signaling to microbial pathogenesis to auto-immune and auto-inflammatory diseases. To effectively train students in such a cross-disciplinary field requires a cohesive and interactive faculty unit with diverse expertise. The 28 UMass Medical School faculties participating in Innate Immunity Training Program (IITP) represent just such a group. Their goal is to provide an outstanding training environment for predoctoral students committed to effectively and creatively expanding our understanding of innate immune mechanisms. This goal will be met by providing predoctoral trainees with: (1) a solid academic background in biochemistry/biophysics, molecular and cellular biology, immunology, and genetics through the UMMS core curriculum and IITP curricular components; (2) an in-depth understanding of rational experimental design as well as the subtleties of the innate immune system interactions through additional regularly scheduled journal clubs, seminar presentations by nationally/internationally recognized experts in the field, as well as by student and faculty IITP members; (3) an innovative, challenging and focused research experience using state of the art technologies; (4) opportunities to present research accomplishments at institutional, local, national and international forums; and (5) appropriate training in the ethical conduct of research. The diverse research interests of our faculty will provide trainees with a wide range of opportunities in both basic and translational research. Particular areas of faculty expertise include innate host defense mechanisms, pathogen evasion, pattern recognition receptor signaling and interactions (Toll-like receptors, NOD-like receptors, and beyond), complement cascades, inflammasome activation, innate-like lymphocyte subsets (B1 B-cells, iNKT cells), protein structure/function, autoimmunity, and vaccine development. We intend to support 10 predoctoral trainees (Ph.D and M.D./Ph.D. students) each year (5 trainees for 2 years each). Trainees will be selected based on their academic record and previous evidence of commitment and talent for basic research. Special efforts will be made to recruit a diverse group of trainees. Training grant funds will enable our group to increase the caliber of student recruits and provide an even more cohesive and rigorous innate immunity research community. PUBLIC HEALTH RELEVANCE: The Innate Immunity Training Program proposed here is designed to educate the next generation of biomedical researchers in cutting-edge, high quality science. Innate immunity is of critical importance to several common human diseases including septic shock, autoimmune diseases, and nearly all infectious diseases. Trainees will receive a comprehensive classroom-based foundation in innate immunity (and allied fields) upon which their laboratory research experience will build.

描述（由申请人提供）：在过去的15年中，我们对先天免疫系统的影响和工作的理解呈指数增长。先天免疫现在是一门复杂的学科，涵盖了从先天免疫受体信号到微生物发病机理再到自身免疫和自身炎症疾病的各种主题。为了有效地在这样的跨学科领域培训学生，需要具有多种专业知识的凝聚力和互动式教师。参加先天免疫培训计划（IITP）的28名UMass医学院教职员工仅代表这样的小组。他们的目标是为致力于有效并创造性地扩大我们对先天免疫机制的理解的典型学生提供出色的培训环境。通过为：（1）通过UMMS核心课程和IITP课程成分提供生物化学/生物物理学，分子和细胞生物学，免疫学和遗传学的生物化学/生物物理学，分子和细胞生物学，免疫学和遗传学的扎实学术背景； （2）通过其他定期安排的期刊俱乐部，该领域的全国/国际认可专家以及学生和教职员工IITP成员的其他定期期刊俱乐部，学生和教职员工IITP成员的其他定期期刊俱乐部的互动，对先天性免疫系统互动的深入了解； （3）使用艺术技术的创新，具有挑战性和专注的研究经验； （4）在机构，地方，国家和国际论坛上提出研究成就的机会； （5）在研究道德行为方面的适当培训。我们教师的多样化研究兴趣将为受训者提供基础研究和转化研究的广泛机会。教师专业知识的特定领域包括先天的宿主防御机制，病原体逃避，模式识别受体信号和相互作用（类似收费的受体，点头样受体，以及其他），补体级联反应，炎症体激活，先天样淋巴细胞类别（B1 B-Cells，Inkt，Inkt，Inkt，Inkt），蛋白质结构/功能，自动化/功能，自动效果，自动效果，自动效果，和效果。我们打算每年支持10名院前学员（Ph.D和M.D./ph.d.学生）（每人2年的5年）。将根据他们的学术记录以及以前的基础研究承诺和才能的证据来选择受训者。将要做出特别的努力来招募一群不同的学员。培训赠款资金将使我们的小组能够提高学生新兵的才能，并提供更加凝聚力和严格的先天免疫研究社区。 公共卫生相关性：此处提出的先天免疫培训计划旨在教育下一代生物医学研究人员有关尖端，高质量科学的教育。先天免疫对于几种常见的人类疾病，包括败血性休克，自身免疫性疾病和几乎所有传染病至关重要。受训人员将获得一个综合的基于教室的基金会基金会（及其盟军领域），其实验室研究经验将建立。