Innate Immunity Training Program

先天免疫训练计划

• 批准号: 10470710
• 负责人: Neal Silverman
• 金额: $ 23.54万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10470710
• 关键词: Natural Immunity; Training Programs

Project Summary Our understanding of the impact and workings of the innate immune system has increased exponentially in the past 25 years. Innate immunity is now a complex discipline that encompasses a variety of topics ranging from innate immune sensing and receptor signaling to microbial pathogenesis to auto-inflammatory and cardiovascular diseases. To effectively train students in such a cross-disciplinary field requires a cohesive and interactive faculty unit with diverse expertise. The 26 UMass Medical School faculty participating in Innate Immunity Training Program (IITP) represent just such a group. Our goal is to provide an outstanding training environment for predoctoral students committed to effectively and creatively expanding our understanding of innate immune mechanisms. This goal will be met by providing predoctoral trainees with: (1) a solid academic background in biochemistry/biophysics, molecular and cellular biology, immunology, and genetics through the UMMS core curriculum and IITP curricular components; (2) an in-depth understanding of rational experimental design as well as the subtleties of the innate immune system interactions through additional regularly scheduled journal clubs, seminar presentations by nationally/internationally recognized experts in the field, as well as by student and faculty IITP members; (3) an innovative, challenging and focused research experience using state of the art technologies; (4) opportunities to present research accomplishments at institutional, local, national and international forums; and (5) appropriate training in the ethical conduct of research. The diverse research interests of our faculty will provide trainees with a wide range of opportunities in both basic and translational research. Particular areas of faculty expertise include innate host defense mechanisms, pathogen evasion, pattern recognition receptor signaling and interactions (Toll-like receptors,NOD-like receptors, and beyond), complement cascades, inflammasome activation, innate-like lymphocyte subsets (B1 B-cells, iNKT cells), protein structure/function, and autoinflammatory diseases. We intend to support 6 predoctoral trainees (Ph.D or M.D./Ph.D. students) each year. Trainees will be selected based on their academic record and previous evidence of commitment to and talent for research. Special efforts will be made to recruit a diverse group of trainees. Training grant funds will enable our program to increase the caliber of student recruits and create an even more rigorous innate immunity research community.

项目摘要 我们对先天免疫系统的影响和工作的理解增加了 在过去的25年中呈指数级。先天免疫现在是一门复杂的学科 涵盖了从先天免疫传感和受体信号到的各种主题 微生物发病机理对自身炎症和心血管疾病。有效训练 这样一个跨学科领域的学生需要一个凝聚力和互动的教师单位 多样的专业知识。参加先天免疫的26名UMass医学院教师 培训计划（IITP）仅代表这样的小组。我们的目标是提供杰出的 培训环境为致力于有效和创造性扩展的专业学生 我们对先天免疫机制的理解。通过提供这个目标 具有：（1）生物化学/生物物理学的扎实学术背景， 通过UMMS核心课程的分子和细胞生物学，免疫学和遗传学 和IITP课程组件； （2）对理性实验设计的深入了解 以及先天免疫系统相互作用的微妙之处。 预定期刊俱乐部，国际/国际认可的专家的研讨会演讲 在该领域，以及学生和教职IITP成员； （3）创新，具有挑战性和 使用艺术技术的重点研究经验； （4）出现的机会 在机构，地方，国家和国际论坛上的研究成就； （5） 适当的研究道德行为培训。 我们教职员工的各种研究兴趣将为受训者提供广泛的 基础研究和转化研究的机会。教师专业知识的特定领域 包括先天的宿主防御机制，病原体逃避，模式识别受体 信号传导和相互作用（Toll样受体，点头样受体及以后），补体 级联，炎性体激活，先天样淋巴细胞亚群（B1 B细胞，Inkt细胞）， 蛋白质结构/功能和自发性疾病。 我们打算每年支持6位术前学员（博士学位或M.D./ph.d.学生）。 学员将根据他们的学术记录和以前的承诺证据进行选择 对研究的才能。将要做出特别的努力来招募一群不同的学员。 培训赠款资金将使我们的计划能够提高学生新兵的才能 创建一个更严格的先天免疫研究社区。