Innate Immunity Training Program

先天免疫训练计划

• 批准号: 10677006
• 负责人: Neal Silverman
• 金额: $ 23.67万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10677006
• 关键词: Natural Immunity; Training Programs

Project Summary Our understanding of the impact and workings of the innate immune system has increased exponentially in the past 25 years. Innate immunity is now a complex discipline that encompasses a variety of topics ranging from innate immune sensing and receptor signaling to microbial pathogenesis to auto-inflammatory and cardiovascular diseases. To effectively train students in such a cross-disciplinary field requires a cohesive and interactive faculty unit with diverse expertise. The 26 UMass Medical School faculty participating in Innate Immunity Training Program (IITP) represent just such a group. Our goal is to provide an outstanding training environment for predoctoral students committed to effectively and creatively expanding our understanding of innate immune mechanisms. This goal will be met by providing predoctoral trainees with: (1) a solid academic background in biochemistry/biophysics, molecular and cellular biology, immunology, and genetics through the UMMS core curriculum and IITP curricular components; (2) an in-depth understanding of rational experimental design as well as the subtleties of the innate immune system interactions through additional regularly scheduled journal clubs, seminar presentations by nationally/internationally recognized experts in the field, as well as by student and faculty IITP members; (3) an innovative, challenging and focused research experience using state of the art technologies; (4) opportunities to present research accomplishments at institutional, local, national and international forums; and (5) appropriate training in the ethical conduct of research. The diverse research interests of our faculty will provide trainees with a wide range of opportunities in both basic and translational research. Particular areas of faculty expertise include innate host defense mechanisms, pathogen evasion, pattern recognition receptor signaling and interactions (Toll-like receptors,NOD-like receptors, and beyond), complement cascades, inflammasome activation, innate-like lymphocyte subsets (B1 B-cells, iNKT cells), protein structure/function, and autoinflammatory diseases. We intend to support 6 predoctoral trainees (Ph.D or M.D./Ph.D. students) each year. Trainees will be selected based on their academic record and previous evidence of commitment to and talent for research. Special efforts will be made to recruit a diverse group of trainees. Training grant funds will enable our program to increase the caliber of student recruits and create an even more rigorous innate immunity research community.

项目概要 我们对先天免疫系统的影响和运作的了解有所增加 过去25年呈指数级增长。先天免疫现在是一门复杂的学科 涵盖各种主题，从先天免疫传感和受体信号传导到 自身炎症和心血管疾病的微生物发病机制。为了有效地训练 在这样一个跨学科领域学习的学生需要一个有凝聚力和互动性的教师单位 多样化的专业知识。参与先天免疫项目的 26 名麻省大学医学院教员 培训计划（IITP）就是这样一个群体的代表。我们的目标是提供出色的 为致力于有效和创造性扩展的博士前学生提供培训环境 我们对先天免疫机制的理解。这一目标将通过提供 博士前学员具有：(1) 扎实的生物化学/生物物理学学术背景， 通过 UMMS 核心课程学习分子和细胞生物学、免疫学和遗传学 和 IITP 课程组成部分； (2)深入理解合理的实验设计 以及先天免疫系统通过额外定期相互作用的微妙之处 预定的期刊俱乐部、国内/国际知名专家的研讨会演讲 现场以及 IITP 学生和教职员工的评价； （三）具有创新性、挑战性和 使用最先进技术的集中研究经验； (4) 展示机会 在机构、地方、国家和国际论坛上取得的研究成果；和（5） 研究道德行为方面的适当培训。 我们教师的多元化研究兴趣将为学员提供广泛的 基础研究和转化研究的机会。教师专业知识的特定领域 包括先天宿主防御机制、病原体逃避、模式识别受体 信号传导和相互作用（Toll 样受体、NOD 样受体等）、补体 级联反应、炎症小体激活、先天样淋巴细胞亚群（B1 B 细胞、iNKT 细胞）、 蛋白质结构/功能和自身炎症性疾病。 我们打算每年支持 6 名博士前培训生（博士或医学博士/博士生）。 将根据他们的学术记录和以前的承诺证据来选择受训者 和研究人才。将特别努力招募多元化的学员。 培训补助金将使我们的计划能够提高学生招募的质量和 创建一个更加严格的先天免疫研究社区。

项目成果

Anti-SARS-CoV-2 Activity of Adamantanes In Vitro and in Animal Models of Infection.

• DOI: 10.3390/covid2110111
• 发表时间: 2022-11
• 期刊: COVID

TRIL is involved in cytokine production in the brain following Escherichia coli infection.

TRIL 参与大肠杆菌感染后大脑中细胞因子的产生。

• DOI: 10.4049/jimmunol.1302392
• 发表时间: 2014-08-15
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Wochal P;Rathinam VA;Dunne A;Carlson T;Kuang W;Seidl KJ;Hall JP;Lin LL;Collins M;Schattgen SA;MacKay CR;Fagundes CT;Carpenter S;Fitzgerald KA;O'Neill LA
• 通讯作者: O'Neill LA

Lesional CD8+ T-Cell Number Predicts Surgical Outcomes of Melanocyte-Keratinocyte Transplantation Surgery for Vitiligo.

病变 CD8 T 细胞数量可预测白癜风黑色素细胞-角质形成细胞移植手术的手术结果。

• DOI: 10.1016/j.jid.2023.03.1689
• 发表时间: 2023
• 期刊: The Journal of investigative dermatology
• 作者: Refat,MaggiA;Strassner,JamesP;Frisoli,MichaelL;Rashighi,Mehdi;Richmond,Jillian;Nada,Essam;Saleh,Ramadan;El-Hamd,MohammedAbu;Goldberg,Dori;Mahmoud,BasselH;Harris,JohnE
• 通讯作者: Harris,JohnE